Results 61 to 70 of about 47,618 (242)

Physcion Protects Against Ethanol-Induced Liver Injury by Reprogramming of Circadian Clock

Frontiers in Pharmacology, 2020
The circadian clock plays a key role in our daily physiology and metabolism. Alcohol consumption disrupts the circadian rhythm of metabolic genes in the liver; however, the potential contribution of circadian clock modulation to alcoholic liver disease ...
Youli Yao, Along Zuo, Qiyu Deng, Shikang Liu, Tianying Zhan, Maolin Wang, Haidong Xu, Junxian Ma, Yingying Zhao   +8 more
doaj   +1 more source

Associations of Sleep and Shift Work with Osteoarthritis Risk

Arthritis Care &Research, Accepted Article.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships between circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000‐person cohort, we evaluated associations between sleep duration, sleeplessness/insomnia, and ...
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Heterogeneous expression of the core circadian clock proteins among neuronal cell types in mouse retina. [PDF]

PLoS ONE, 2012
Circadian rhythms in metabolism, physiology, and behavior originate from cell-autonomous circadian clocks located in many organs and structures throughout the body and that share a common molecular mechanism based on the clock genes and their protein ...
Xiaoqin Liu, Zhijing Zhang, Christophe P Ribelayga   +2 more
doaj   +1 more source

Drosophila Clock Can Generate Ectopic Circadian Clocks [PDF]

Cell, 2003
Circadian rhythms of behavior, physiology, and gene expression are present in diverse tissues and organisms. The function of the transcriptional activator, Clock, is necessary in both Drosophila and mammals for the expression of many core clock components.
Zhao, Jie, Kilman, Valerie L, Keegan, Kevin P, Peng, Ying, Emery, Patrick, Rosbash, Michael, Allada, Ravi   +6 more
openaire   +2 more sources

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Circadian clock control of Nox4 and reactive oxygen species in the vasculature.

PLoS ONE, 2013
Recent studies have shown that circadian clock disruption is associated with pathological remodeling in the arterial structure and vascular stiffness.
Ciprian B Anea, Maoxiang Zhang, Feng Chen, M Irfan Ali, C Michael M Hart, David W Stepp, Yevgeniy O Kovalenkov, Ana-Maria Merloiu, Paramita Pati, David Fulton, R Daniel Rudic   +10 more
doaj   +1 more source

Transcriptomal dissection of soybean circadian rhythmicity in two geographically, phenotypically and genetically distinct cultivars

BMC Genomics, 2021
Background In soybean, some circadian clock genes have been identified as loci for maturity traits. However, the effects of these genes on soybean circadian rhythmicity and their impacts on maturity are unclear.
Yanlei Yue, Ze Jiang, Enoch Sapey, Tingting Wu, Shi Sun, Mengxue Cao, Tianfu Han, Tao Li, Hai Nian, Bingjun Jiang   +9 more
doaj   +1 more source

Thermal Plasticity is Regulated by a Key MicroRNA During Range Expansion of an Invasive Fruit Fly

Advanced Science, EarlyView.
Populations at the invasion front of Bactrocera dorsalis adapt through reduced phenotypic and gene expression plasticity, a phenomenon likely to be driven by genetic assimilation. We identify a key miRNA‐mediated regulatory axis, in which miR‐276b post‐transcriptionally represses thw, a conserved chitin‐binding gene critical to the cold‐tolerance ...
Yan Zhao, Juntao Hu, Juan Du, Shaokun Guo, Youming Hou, Zhihong Li   +5 more
wiley   +1 more source

Small Molecule Modulators of the Circadian Molecular Clock With Implications for Neuropsychiatric Diseases

Frontiers in Molecular Neuroscience, 2019
Circadian rhythms regulate many biological processes and play fundamental roles in behavior, physiology, and metabolism. Such periodicity is critical for homeostasis because disruption or misalignment of the intrinsic rhythms is associated with the onset
Hyo Kyeong Cha, Sooyoung Chung, Hye Young Lim, Jong-Wha Jung, Gi Hoon Son   +4 more
doaj   +1 more source

Circadian Clocks Make Metabolism Run

Journal of Molecular Biology, 2020
Most organisms adapt to the 24-h cycle of the Earth's rotation by anticipating the time of the day through light-dark cycles. The internal time-keeping system of the circadian clocks has been developed to ensure this anticipation. The circadian system governs the rhythmicity of nearly all physiological and behavioral processes in mammals.
Sinturel, Flore, Petrenko, Volodymyr, Dibner, Charna   +2 more
openaire   +4 more sources