Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines.
Laura Bindila +11 more
wiley +1 more source
In vitro and in vivo Phase Changes of the Mouse Circadian Clock by Oxidative Stress
Journal of Circadian Rhythms, 2016 Mammalian circadian rhythms are governed by an endogenous circadian clock system, including the molecular clock works in each cell and tissue. Adaptation of the circadian clock to different environmental stimuli such as light, food, and stress is ...
Yu Tahara +6 more
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Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock. [PDF]
PLoS ONE, 2011 Circadian clocks coordinate the timing of important biological processes. Interconnected transcriptional and post-translational feedback loops based on a set of clock genes generate and maintain these rhythms with a period of about 24 hours.
Isabelle Schmutz +5 more
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Antagonistic Regulation of Circadian Output and Synaptic Development by JETLAG and the DYSCHRONIC-SLOWPOKE Complex [PDF]
, 2020 Circadian output genes act downstream of the clock to promote rhythmic changes in behavior and physiology, yet their molecular and cellular functions are not well understood. Here we characterize an interaction between regulators of circadian entrainment,
Akpoghiran, Oghenerukevwe +3 more
core +1 more source
A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line [PDF]
, 2019 The circadian clock regulates key cellular processes and its dysregulation is associated to several pathologies including cancer. Although the transcriptional regulation of gene expression by the clock machinery is well described, the role of the clock ...
Abreu, Mónica +4 more
core +1 more source
The Circadian Clock in White and Brown Adipose Tissue: Mechanistic, Endocrine, and Clinical Aspects.
Endocrine reviews, 2018 Obesity is a major risk factor for the development of illnesses, such as insulin resistance and hypertension, and has become a serious public health problem. Mammals have developed a circadian clock located in the hypothalamic suprachiasmatic nuclei (SCN)
O. Froy, M. Garaulet
semanticscholar +1 more source
Glucocorticoids and the circadian clock [PDF]
Journal of Endocrinology, 2008 Glucocorticoids, hormones produced by the adrenal gland cortex, perform numerous functions in body homeostasis and the response of the organism to external stressors. One striking feature of their regulation is a diurnal release pattern, with peak levels linked to the start of the activity phase. This release is under control of the circadian clock, an
openaire +4 more sources
The circadian clock goes genomic [PDF]
Genome Biology, 2013 Large-scale biology among plant species, as well as comparative genomics of circadian clock architecture and clock-regulated output processes, have greatly advanced our understanding of the endogenous timing system in plants.
Staiger, Dorothee +3 more
openaire +5 more sources
A scenario of unhealthy life cycle: The role of circadian rhythms in health
Aging MedicineCircadian rhythms are oscillations in physiology and behavior caused by the circadian regulator. Cryptochromes, Periods, and Bmal1 are circadian clock genes that have been linked to aging and cancer.
Manasa Chandramouli +2 more
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Silybin A enhances circadian clock by targeting CRY1 and disrupting its interaction with CLOCK
Pharmacological Research - Modern Chinese Medicine, 2022 Circadian clock governs a large array of physiological and metabolic functions. The amplitude decline of circadian rhythm is associated with various chronic diseases. However, few clock enhancing-molecules are known. CRY1 is one of the main components of
Weijie Bian +4 more
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