Results 81 to 90 of about 120,096 (334)

Effect of H₂S on the circadian rhythm of mouse hepatocytes

Lipids in Health and Disease, 2012
Background Dysregulation of circadian rhythms can contribute to diseases of lipid metabolism. NAD-dependent deacetylase sirtuin-1(SIRT1) is an important hub which links lipid metabolism with circadian clock by its deacetylation activity depends on ...
Shang Zhanxian, Lu Chao, Chen Sifeng, Hua Luchun, Qian Ruizhe   +4 more
doaj   +1 more source

Period 2: A Regulator of Multiple Tissue-Specific Circadian Functions

Frontiers in Molecular Neuroscience, 2021
The zebrafish represents a powerful model for exploring how light regulates the circadian clock due to the direct light sensitivity of its peripheral clocks, a property that is retained even in organ cultures as well as zebrafish-derived cell lines ...
Gennaro Ruggiero, Gennaro Ruggiero, Zohar Ben-Moshe Livne, Yair Wexler, Nathalie Geyer, Daniela Vallone, Yoav Gothilf, Yoav Gothilf, Nicholas S. Foulkes   +8 more
doaj   +1 more source

Coordinated transcriptional regulation between a reactive oxygen species-responsive gene network and the circadian clock in Arabidopsis thaliana : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Plant Biology at Massey University, Plant Biology, New Zealand [PDF]

, 2012
Most organisms have evolved endogenous biological clocks as internal timekeepers to fine-tune physiological processes to the external environment. Energetic cycles such as photosynthesis and glycolytic cycles are physiological processes that have ...
Lai, Alvina Grace
core  

Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer\u27s disease [PDF]

, 2020
A promising new therapeutic target for the treatment of Alzheimer\u27s disease (AD) is the circadian system. Although patients with AD are known to have abnormal circadian rhythms and suffer sleep disturbances, the role of the molecular clock in ...
Griffin, Percy, Kim, Do Eon, Kim, Dong-Hou, Lee, Jiyeon, Musiek, Erik S, Sheehan, Patrick W, Yoon, Seung-Yong   +6 more
core   +1 more source

Circadian Organization in Hemimetabolous Insects [PDF]

, 2004
The circadian system of hemimetabolous insects is reviewed in respect to the locus of the circadian clock and multioscillatory organization. Because of relatively easy access to the nervous system, the neuronal organization of the clock system in ...
Abe Y., Balkenohl M., Cymborowski B., Eskin A., Hardeland R., Helfrich-Förster C., Ikeda M., Mote M. I., Nishinokubi I., Petri B., Petri B., Pflugfelder O., Saifullah A. S. M., Shiga S., Tomioka K., Tomioka K., Tomioka K., Ushirogawa H.   +17 more
core   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Heterogeneous expression of the core circadian clock proteins among neuronal cell types in mouse retina. [PDF]

PLoS ONE, 2012
Circadian rhythms in metabolism, physiology, and behavior originate from cell-autonomous circadian clocks located in many organs and structures throughout the body and that share a common molecular mechanism based on the clock genes and their protein ...
Xiaoqin Liu, Zhijing Zhang, Christophe P Ribelayga   +2 more
doaj   +1 more source

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

The circadian clock coordinates ribosome biogenesis.

PLoS Biology, 2013
Biological rhythms play a fundamental role in the physiology and behavior of most living organisms. Rhythmic circadian expression of clock-controlled genes is orchestrated by a molecular clock that relies on interconnected negative feedback loops of ...
Céline Jouffe, Gaspard Cretenet, Laura Symul, Eva Martin, Florian Atger, Felix Naef, Frédéric Gachon   +6 more
doaj   +1 more source

Transcriptomal dissection of soybean circadian rhythmicity in two geographically, phenotypically and genetically distinct cultivars

BMC Genomics, 2021
Background In soybean, some circadian clock genes have been identified as loci for maturity traits. However, the effects of these genes on soybean circadian rhythmicity and their impacts on maturity are unclear.
Yanlei Yue, Ze Jiang, Enoch Sapey, Tingting Wu, Shi Sun, Mengxue Cao, Tianfu Han, Tao Li, Hai Nian, Bingjun Jiang   +9 more
doaj   +1 more source