Results 81 to 90 of about 347,727 (386)

A scenario of unhealthy life cycle: The role of circadian rhythms in health

Aging Medicine
Circadian rhythms are oscillations in physiology and behavior caused by the circadian regulator. Cryptochromes, Periods, and Bmal1 are circadian clock genes that have been linked to aging and cancer.
Manasa Chandramouli, Vrushabendra Basavanna, Srikantamurthy Ningaiah   +2 more
doaj   +1 more source

Silybin A enhances circadian clock by targeting CRY1 and disrupting its interaction with CLOCK

Pharmacological Research - Modern Chinese Medicine, 2022
Circadian clock governs a large array of physiological and metabolic functions. The amplitude decline of circadian rhythm is associated with various chronic diseases. However, few clock enhancing-molecules are known. CRY1 is one of the main components of
Weijie Bian, Weilin Zhang, Hao Liang, Xiaowen Xie, Luhua Lai   +4 more
doaj  

Waveforms of molecular oscillations reveal circadian timekeeping mechanisms [PDF]

Commun. Biol. 1, 207 (2018), 2018
Circadian clocks play a pivotal role in orchestrating numerous physiological and developmental events. Waveform shapes of the oscillations of protein abundances can be informative about the underlying biochemical processes of circadian clocks. We derive a mathematical framework where waveforms do reveal hidden biochemical mechanisms of circadian ...
arxiv   +1 more source

The circadian clock of CD8 T cells modulates their early response to vaccination and the rhythmicity of related signaling pathways

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Circadian clocks control various aspects of physiology. The circadian control of the response of T cells to antigen presentation, which is at the core of the specific immune response to pathogens, has remained unclear.
C. Nobis, Geneviève Dubeau Laramée, L. Kervezee, Dave Maurice De Sousa, N. Labrecque, N. Cermakian   +5 more
semanticscholar   +1 more source

Claustrum Volume Is Reduced in Multiple Sclerosis and Predicts Disability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The claustrum is a small, thin structure of predominantly gray matter with broad connectivity and enigmatic function. Little is known regarding the impact of claustrum pathology in multiple sclerosis (MS). Methods This study assessed whether claustrum volume was reduced in MS and whether reductions were associated with specific ...
Nicole Shelley, Bradley Judge, Dmitriy A. Yablonskiy, Robert T. Naismith, Matthew R. Brier, Anne H. Cross   +5 more
wiley   +1 more source

Circadian clock control of Nox4 and reactive oxygen species in the vasculature. [PDF]

PLoS ONE, 2013
Recent studies have shown that circadian clock disruption is associated with pathological remodeling in the arterial structure and vascular stiffness.
Ciprian B Anea, Maoxiang Zhang, Feng Chen, M Irfan Ali, C Michael M Hart, David W Stepp, Yevgeniy O Kovalenkov, Ana-Maria Merloiu, Paramita Pati, David Fulton, R Daniel Rudic   +10 more
doaj   +1 more source

On the robustness of the in vivo cyanobacterial circadian clock [PDF]

arXiv, 2022
We propose a revisited version of the in vivo model of the cyanobacterial circadian clock. Our aim is to address the lack of robustness predicted for the mutant cyanobacteria without transcriptional regulation of the original model. For this, we rely on an in vitro model of the clock describing explicitly the hexameric structure of the core protein of ...
arxiv  

Cell-autonomous regulation of astrocyte activation by the circadian clock protein BMAL1

bioRxiv, 2018
Circadian clock dysfunction is a common symptom of aging and neurodegenerative diseases, though its impact on brain health is poorly understood. Astrocyte activation occurs in response to diverse insults, and plays a critical role in brain health and ...
Brian V. Lananna, C. Nadarajah, Mariko Izumo, Michelle R Cedeno, David D. Xiong, J. Dimitry, C. Tso, Celia A. McKee, Percy Griffin, Patrick W. Sheehan, J. Haspel, B. Barres, S. A. Liddelow, J. Takahashi, I. Karatsoreos, E. Musiek   +15 more
semanticscholar   +1 more source

SnapShot: Circadian Clock

Cell, 2017
Most creatures on this planet possess an ability to anticipate upcoming events in the environment, courtesy of their circadian clocks. This allows them to prepare for those changes instead of being caught by surprise, which could mean the difference between life and death. In this SnapShot, we describe the basics of how the clock ticks.
Dragana Rogulja, Bryan J. Song
openaire   +2 more sources

Circadian Clocks, Stress, and Immunity [PDF]

Frontiers in Endocrinology, 2016
In mammals, molecular circadian clocks are present in most cells of the body, and this circadian network plays an important role in synchronizing physiological processes and behaviors to the appropriate time of day. The hypothalamic-pituitary-adrenal endocrine axis regulates the response to acute and chronic stress, acting through its final effectors -
Dumbell, R, Matveeva, O, Oster, H
openaire   +3 more sources