Results 91 to 100 of about 67,567 (286)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source

Altered circadian expression of clock genes and clock-regulatory epigenetic modifiers in saliva of children with fetal alcohol spectrum disorders

Scientific Reports
Prenatal alcohol-exposed (AE) infants and children often demonstrate disrupted sleep patterns, including more frequent awakenings, reduced total sleep time, and more night-to-night sleep variability.
Ujjal Das, Jennifer D. Thomas, Prashant Tarale, Jackie Soja, Sarah Inkelis, Christina Chambers, Dipak K. Sarkar   +6 more
doaj   +1 more source

Profiling of circadian genes expressed in the uterus endometrial stromal cells of pregnant rats as revealed by DNA microarray coupled with RNA interference

Frontiers in Endocrinology, 2013
The peripheral circadian oscillator plays an essential role in synchronizing local physiology to operate in a circadian manner via regulation of the expression of clock-controlled genes.
Hirotaka eTasaki, Lijia eZhao, Keishiro eIsayama, Huatao eChen, Nobuhiko eYamauchi, Yasufumi eShigeyoshi, Seiichi eHashimoto, Masa-Aki eHattori   +7 more
doaj   +1 more source

Machine learning and expression analyses reveal circadian clock features predictive of anxiety

Scientific Reports, 2022
Mood disorders, including generalized anxiety disorder, are associated with disruptions in circadian rhythms and are linked to polymorphisms in circadian clock genes.
Aziz Zafar, Rebeccah Overton, Ziad Attia, Ahmet Ay, Krista Ingram   +4 more
doaj   +1 more source

Evolutionary relationships among barley and Arabidopsis core circadian clock and clock-associated genes [PDF]

, 2015
The circadian clock regulates a multitude of plant developmental and metabolic processes. In crop species, it contributes significantly to plant performance and productivity and to the adaptation and geographical range over which crops can be grown.
A Helfer, A Para, A Pokhilko, A Pokhilko, A Turner, A Zimmer, AB James, AB James, AH Paterson, AN Dodd, B Yu, BS Shin, BY Chow, C Campoli, C Campoli, C Campoli, C Li, C Lillo, C Troein, CR McClung, Cristiane P. G. Calixto, CT Hotta, D Alabadí, DA Matos, DB Fowler, DH Nagel, E Kolmos, E Ogiso, E Tauber, F Prosdocimi, F Valverde, F Yon, H Okamura, HR Song, J Cockram, J Felsenstein, JA Higgins, JC Locke, JC Schnable, JM Gendron, John W. S. Brown, JW Yu, K Holm, K Onai, K Tamura, K Tamura, KF Mayer, L Vallelian-Bindschedler, M Endo, M Gallego, M Iwamoto, M Klintenäs, M Martínez, M Murakami, M Serikawa, MA Larkin, MF Covington, MJ Haydon, MJ Moore, MN Zeilinger, N Nakamichi, N Nakamichi, N Saitou, N Suetsugu, N Takata, N Takata, P Lou, PA Pin, R Hayama, R Nitcher, R Poiré, RM Green, Robbie Waugh, RP Dunford, S Faure, S Faure, S Griffiths, S Nagasaka, S Stracke, S Zakhrabekova, SB Satbhai, SE Sanchez, SF Altschul, SF Boxall, SL Harmer, SL Harmer, SM Chaw, T Matsumoto, TA Miller, TP Michael, W Huang, W-Y Kim, X Wang, Y Kobayashi, Z Chen   +94 more
core   +3 more sources

Circadian clock genes and the transcriptional architecture of the clock mechanism [PDF]

Journal of Molecular Endocrinology, 2019
The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism (such as eating and sleeping) helps different tissue and organ systems coordinate and optimize their performance. The full extent of the mechanisms by which cells maintain
Kimberly H, Cox, Joseph S, Takahashi
openaire   +2 more sources

Associations of Sleep and Shift Work with Osteoarthritis Risk

Arthritis Care &Research, Accepted Article.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships between circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000‐person cohort, we evaluated associations between sleep duration, sleeplessness/insomnia, and ...
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Evidence for widespread dysregulation of circadian clock progression in human cancer [PDF]

PeerJ, 2018
The ubiquitous daily rhythms in mammalian physiology are guided by progression of the circadian clock. In mice, systemic disruption of the clock can promote tumor growth. In vitro, multiple oncogenes can disrupt the clock.
Jarrod Shilts, Guanhua Chen, Jacob J. Hughey   +2 more
doaj   +2 more sources

Identification of Melatonin-Regulated Genes in the Ovine Pituitary Pars Tuberalis, a Target Site for Seasonal Hormone Control [PDF]

, 2008
The pars tuberalis (PT) of the pituitary gland expresses a high density of melatonin (MEL) receptors and is believed to regulate seasonal physiology by decoding changes in nocturnal melatonin secretion.
Alison Downing, Ando, Andrew S. I. Loudon, Ashburner, Bae, Barrett, Bartness, Bechtold, Benoit Malpaux, Bockers, Bockers, Bockmann, Brahimi-Horn, Camon, Carr, Chemineau, Chen, Curlewis, Daphne Mouzaki, Dardente, Dave W. Burt, David Waddington, Draghici, Dupre, Fukuhara, Gerald A. Lincoln, Ghorbel, Graham, Grossmann, Hanon, Hazlerigg, Hazlerigg, Hazlerigg, Hogenesch, Hu, Hu, Johnston, Johnston, Johnston, Julian R. E. Davis, Kel, Kijas, Klosen, Ko, Lamolet, Lee, Lincoln, Lincoln, Lincoln, Lincoln, Malpaux, Merks, Messager, Michan, Morgan, Morgan, Mutoh, Nakao, Naya, Naya, Nilaweera, Oki, Poulin, Reick, Revollo, Richard Talbot, Roepke, Rutter, Samal, Sandrine M. Dupré, Schroeder, Segawa, Stehle, Stirland, Storey, Su, Tobler, Tournier, Wagner, Westfall, Williams, Wittkowski, Yang, Yokoyama   +83 more
core   +2 more sources