Results 261 to 270 of about 67,567 (286)

Circadian clock genes and sleep homeostasis

European Journal of Neuroscience, 2009
AbstractCircadian and sleep‐homeostatic processes both contribute to sleep timing and sleep structure. Elimination of circadian rhythms through lesions of the suprachiasmatic nuclei (SCN), the master circadian pacemaker, leads to fragmentation of wakefulness and sleep but does not eliminate the homeostatic response to sleep loss as indexed by the ...
Franken, P, Dijk, D-J
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From circadian clock gene expression to pathologies

Sleep Medicine, 2007
In most organisms, circadian rhythms are generated by a molecular clockwork involving so-called clock genes. These circadian clock genes participate in regulatory feedback loops, in which proteins regulate their own expression. The outcome is that ribonucleic acids (RNAs) and proteins produced from many of these genes oscillate with a circadian rhythm.
Elaine Waddington, Lamont, Francine O, James, Diane B, Boivin, Nicolas, Cermakian   +3 more
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Molecular analysis of avian circadian clock genes

Molecular Brain Research, 2000
Unlike mammals, avian circadian rhythms are regulated by a multiple oscillatory system consisting of the retina, the pineal and the suprachiasmatic nucleus in the hypothalamus. To understand avian circadian system, we have cloned Clock and Period homologs (qClock, qPer2 and qPer3) and characterized these genes in Japanese quail.
T, Yoshimura, Y, Suzuki, E, Makino, T, Suzuki, A, Kuroiwa, Y, Matsuda, T, Namikawa, S, Ebihara   +7 more
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Circadian-clock regulation of gene expression

Current Opinion in Genetics & Development, 1993
During the past year, our understanding of the cellular and molecular processes involved in the generation and control of circadian rhythms has advanced significantly. Progress has been made at the level of the circadian pacemaker mechanism itself, the input pathways that regulate the pacemaker, and the mechanisms by which the pacemaker regulates its ...
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Circadian clock genes Bmal1 and Clock during early chick development

Developmental Dynamics, 2012
AbstractBackground: The circadian clock is a well‐described temporal organizer in adult organisms. Despite the particularly evident need for temporal control during embryo development, the effect of environmental cues is still greatly neglected. Few studies have reported circadian clock gene expression in early embryonic stages.
Gonçalves, Lisa, Vinhas, Maurícia, Pereira, Rui, Pais De Azevedo, Tomás, Bajanca, Fernanda, Palmeirim, Isabel   +5 more
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Circadian expression of clock genes and clock-controlled genes in the rat retina

Biochemical and Biophysical Research Communications, 2005
The circadian expression patterns of genes encoding for proteins that make up the core of the circadian clock were measured in rat retina using real-time quantitative PCR (qPCR). Transcript levels of several genes previously used for normalization of qPCR assays were determined and the effect of ischemia-reperfusion on the expression of clock genes was
Kamphuis, Willem, Cailotto, Cathy, Dijk, Frederike, Bergen, Arthur, Buijs, Ruud M.   +4 more
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The Search for Circadian Clock and Sleep Genes

Journal of Psychopharmacology, 1999
In recent years, there has been extraordinary progress in elucidating the molecular components of the mammalian circadian clock system. The discovery of circadian clock genes in lower organisms (such as fruit flies and fungi), which show many similarities with clock genes in mammals, together with advances in mouse molecular genetics have led to major
D E, Kolker, F W, Turek
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Circadian Rhythm, Clock Genes, and Stroke

Current Neurovascular Research

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Invited Review: Regulation of mammalian circadian clock genes

Journal of Applied Physiology, 2002
The circadian clock is a self-sustaining oscillator that has a period of ∼24 h and controls many physiological and behavioral systems. This clock can synchronize itself to changing environmental conditions to optimize an organisms performance. The underlying circadian rhythms are generated by periodic activation of transcription by a set of clock genes.
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Gene duplication and complex circadian clocks in mammals

Trends in Genetics, 2005
The circadian clock arose early in the evolution of life to enable organisms to adapt to the cycle of day and night. Recently, the extent and importance of circadian regulation of behaviour and physiology has come to be more fully realized. Core molecular cogs of circadian oscillators appear to have been largely conserved between such diverse organisms
Looby, Paul, Loudon, Andrew S I
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