Results 41 to 50 of about 33,176 (266)

The Circadian Clock-controlled Transcriptome of Developing Soybean Seeds

The Plant Genome, 2010
A number of metabolic and physiological processes in plants are controlled by the circadian clock, which enables a plant to anticipate daily changes in the environment.
Karen A. Hudson
doaj   +1 more source

Clock Genes Show Circadian Rhythms in Salivary Glands [PDF]

Journal of Dental Research, 2012
Circadian rhythms are endogenous self-sustained oscillations with 24-hour periods that regulate diverse physiological and metabolic processes through complex gene regulation by “clock” transcription factors. The oral cavity is bathed by saliva, and its amount and content are modified within regular daily intervals.
L, Zheng, Y J, Seon, J, McHugh, S, Papagerakis, P, Papagerakis   +4 more
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Heritable gene expression variability and stochasticity govern clonal heterogeneity in circadian period.

PLoS Biology, 2020
A ubiquitous feature of the circadian clock across life forms is its organization as a network of cellular oscillators, with individual cellular oscillators within the network often exhibiting considerable heterogeneity in their intrinsic periods.
K L Nikhil, Sandra Korge, Achim Kramer
doaj   +1 more source

Circadian disruption, clock genes, and metabolic health

Journal of Clinical Investigation
A growing body of research has identified circadian-rhythm disruption as a risk factor for metabolic health. However, the underlying biological basis remains complex, and complete molecular mechanisms are unknown. There is emerging evidence from animal and human research to suggest that the expression of core circadian genes, such as circadian ...
Schrader, Lauren A., Ronnekleiv-Kelly, Sean M., Hogenesch, John B., Bradfield, Christopher A., Malecki, Kristen M.C.   +4 more
openaire   +2 more sources

Diapause: Circadian Clock Genes Are at It Again [PDF]

Current Biology, 2019
Understanding how insects synchronize their annual life cycle to local conditions remains poorly understood. A new study integrates a QTL investigation with population genomic analyses in a Lepidopteran to show that, yet again, allelic variation in circadian clock genes has a role in seasonal timing of diapause.
Karl, Gotthard, Christopher W, Wheat
openaire   +2 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Comparative analysis of circadian clock genes in insects [PDF]

Insect Molecular Biology, 2008
Summary After a slow start, the comparative analysis of clock genes in insects has developed into a mature area of study in recent years. Brain transplant or surgical interventions in larger insects defined much of the early work in this area, before the cloning of clock genes became possible.
SANDRELLI, FEDERICA, COSTA, RODOLFO, KYRIACOU C. P, ROSATO E.   +3 more
openaire   +4 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source