Results 61 to 70 of about 33,176 (266)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source

Altered circadian expression of clock genes and clock-regulatory epigenetic modifiers in saliva of children with fetal alcohol spectrum disorders

Scientific Reports
Prenatal alcohol-exposed (AE) infants and children often demonstrate disrupted sleep patterns, including more frequent awakenings, reduced total sleep time, and more night-to-night sleep variability.
Ujjal Das, Jennifer D. Thomas, Prashant Tarale, Jackie Soja, Sarah Inkelis, Christina Chambers, Dipak K. Sarkar   +6 more
doaj   +1 more source

MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation

Nature Communications, 2016
The circadian clock and the cell cycle systems coordinate global physiology. Here the authors show that MYC represses the clock genes, together with MIZ1, and induces proliferation, suggesting that MYC inversely modulates cell cycle and circadian clock ...
Anton Shostak, Bianca Ruppert, Nati Ha, Philipp Bruns, Umut H. Toprak, ICGC MMML-Seq Project, Roland Eils, Matthias Schlesner, Axel Diernfellner, Michael Brunner   +9 more
doaj   +1 more source

Profiling of circadian genes expressed in the uterus endometrial stromal cells of pregnant rats as revealed by DNA microarray coupled with RNA interference

Frontiers in Endocrinology, 2013
The peripheral circadian oscillator plays an essential role in synchronizing local physiology to operate in a circadian manner via regulation of the expression of clock-controlled genes.
Hirotaka eTasaki, Lijia eZhao, Keishiro eIsayama, Huatao eChen, Nobuhiko eYamauchi, Yasufumi eShigeyoshi, Seiichi eHashimoto, Masa-Aki eHattori   +7 more
doaj   +1 more source

Machine learning and expression analyses reveal circadian clock features predictive of anxiety

Scientific Reports, 2022
Mood disorders, including generalized anxiety disorder, are associated with disruptions in circadian rhythms and are linked to polymorphisms in circadian clock genes.
Aziz Zafar, Rebeccah Overton, Ziad Attia, Ahmet Ay, Krista Ingram   +4 more
doaj   +1 more source

Circadian clock genes and the transcriptional architecture of the clock mechanism [PDF]

Journal of Molecular Endocrinology, 2019
The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism (such as eating and sleeping) helps different tissue and organ systems coordinate and optimize their performance. The full extent of the mechanisms by which cells maintain
Kimberly H, Cox, Joseph S, Takahashi
openaire   +2 more sources

Associations of Sleep and Shift Work With Osteoarthritis Risk

Arthritis Care &Research, EarlyView.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Evidence for widespread dysregulation of circadian clock progression in human cancer [PDF]

PeerJ, 2018
The ubiquitous daily rhythms in mammalian physiology are guided by progression of the circadian clock. In mice, systemic disruption of the clock can promote tumor growth. In vitro, multiple oncogenes can disrupt the clock.
Jarrod Shilts, Guanhua Chen, Jacob J. Hughey   +2 more
doaj   +2 more sources

Thermal Plasticity is Regulated by a Key MicroRNA During Range Expansion of an Invasive Fruit Fly

Advanced Science, EarlyView.
Populations at the invasion front of Bactrocera dorsalis adapt through reduced phenotypic and gene expression plasticity, a phenomenon likely to be driven by genetic assimilation. We identify a key miRNA‐mediated regulatory axis, in which miR‐276b post‐transcriptionally represses thw, a conserved chitin‐binding gene critical to the cold‐tolerance ...
Yan Zhao, Juntao Hu, Juan Du, Shaokun Guo, Youming Hou, Zhihong Li   +5 more
wiley   +1 more source