Results 161 to 170 of about 342,113 (368)
Supplementary Figure 1 from A Circadian Clock Transcription Model for the Personalization of Cancer Chronotherapy [PDF]
, 2023 Xiaomei Li +10 more
openalex +1 more source
Advanced Science, EarlyView.Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély +5 more
wiley +1 more source
Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age [PDF]
, 2015 Ziv Zwighaft +10 more
openalex +1 more source
Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance
Advanced Science, EarlyView.DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin +15 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.Adaptive multi‐indicator contrastive predictive coding is introduced as a self‐supervised pretraining framework for multivariate EHR time series. An adaptive sliding‐window algorithm and 2D convolutional neural network encoder capture localized temporal patterns and global indicator dependencies, enabling label‐efficient disease prediction that ...
Hongxu Yuan +3 more
wiley +1 more source
Circadian clock gene variants may affect circadian fluctuations of anaerobic performance
, 2021 Tülin Atan +4 more
openalex +1 more source
Central and peripheral circadian clocks in mammals.
Annual Review of Neuroscience, 2012 J. Mohawk, C. Green, J. Takahashi
semanticscholar +1 more source
Multimorbidity and animal models
Animal Models and Experimental Medicine, EarlyView.Multimorbidity, defined as the coexistence of ≥2 chronic conditions, is associated with aging, genetics, and environmental factors. Animal models in multimorbidity research span three tiers: simple organisms for initial screening → rodents for mechanistic analysis → large mammals for clinical prediction.
Xinpei Wang +7 more
wiley +1 more source