Results 281 to 290 of about 336,986 (421)

Parasite and vector circadian clocks mediate efficient malaria transmission. [PDF]

Nat Microbiol
Bento I, Parrington BA, Pascual R, Goldberg AS, Wang E, Liu H, Borrmann H, Zelle M, Coburn N, Takahashi JS, Elias JE, Mota MM, Rijo-Ferreira F.   +12 more
europepmc   +1 more source

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source

Involvement of the MAP kinase cascade in resetting of the mammalian circadian clock [PDF]

, 2000
Makoto Akashi, Eisuke Nishida
openalex   +1 more source

Blue light restores functional circadian clocks in eyeless cave spiders. [PDF]

Sci Adv
Wang J, Chang J, Wang K, Liang B, Zhu Y, Liu Z, Liang X, Chen J, Peng Y, Agnarsson I, Li D, Liu J.   +11 more
europepmc   +1 more source

Analysis of C4 Concentrations to Predict Impact of Patient‐Reported Diarrhea Associated With the Ileal Bile Acid Transporter Inhibitor Linerixibat

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 596-605, March 2025.
ABSTRACT Linerixibat, an ileal bile acid transporter (IBAT) inhibitor, is being evaluated for the treatment of pruritus in primary biliary cholangitis (PBC). Diarrhea is commonly reported with this drug class as IBAT inhibition redirects bile acids (BA) to the colon.
Fernando Carreño, Rashmi Mehta, Andrea Ribeiro de Souza, Jon Collins, Brandon Swift   +4 more
wiley   +1 more source

Molecular Clock Genes in Man and Lower Animals Possible Implications for Circadian Abnormalities in Depression [PDF]

, 2000
William E. Bunney
openalex   +1 more source

Time is honey: circadian clocks of bees and flowers and how their interactions may influence ecological communities

Philosophical Transactions of the Royal Society B: Biological Sciences, 2017
G. Bloch, Noam Bar-Shai, Yotam Cytter, R. Green   +3 more
semanticscholar   +1 more source

Alternative splicing of Clock transcript mediates the response of circadian clocks to temperature changes. [PDF]

Proc Natl Acad Sci U S A
Cai YD, Liu X, Chow GK, Hidalgo S, Jackson KC, Vasquez CD, Gao ZY, Lam VH, Tabuloc CA, Zheng H, Zhao C, Chiu JC.   +11 more
europepmc   +1 more source

Circadian clocks and their integration with metabolic and reproductive systems: our current understanding and its application to the management of dairy cows. [PDF]

J Anim Sci, 2022
Casey TM, Plaut K.
europepmc   +1 more source

Establishing the Exposure‐QT Relationship During Bedaquiline Treatment Using a Time‐Varying Tuberculosis‐Specific Correction Factor (QTcTBT)

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Evaluating QT prolongation induced by anti‐tuberculosis (TB) drugs in patients with active TB, who often experience tachycardia, is challenging due to the limitations of Fridericia's correction factor (QTcF) in decorrelating QTc from heart rate (HR).
Thanakorn Vongjarudech, Anne‐Gaëlle Dosne, Bart Remmerie, Mats O. Karlsson, Elin M. Svensson   +4 more
wiley   +1 more source