Results 371 to 380 of about 336,986 (421)
Aging Cell, Volume 24, Issue 5, May 2025.An endochondral differentiation process in the CEPs drives pathologic disc calcification in aging LG/J mice, and NP cell hypertrophic transdifferentiation secondarily contributes. Supplementing drinking water with 80 mM K3Citrate during aging markedly reduced disc calcification, attenuated NP cell transdifferentiation, and mildly improved NP and AF ...
Olivia K. Ottone +9 more
wiley +1 more source
The Impact of Toll‐Like Receptor 5 on Liver Function in Age‐Related Metabolic Disorders
Aging Cell, EarlyView.Toll‐like receptor 5 (TLR5) deficiency accelerates age‐related metabolic disorders, leading to obesity, fatty liver, and cellular changes such as lipid accumulation in PMHs (hepatocytes) and activation of HSCs (hepatic stellate cells), which drive fibrosis.
Dong‐Hyun Kim +9 more
wiley +1 more source
Aging Cell, EarlyView.This study demonstrates that reducing the enzyme topoisomerase Top2 or its mammalian homolog TOP2B promotes longevity across multiple species, including yeast, worms, and mice. At the cellular/molecular level, TOP2B reduction mitigates the major cellular aging hallmarks such as epigenetic alterations, cell senescence, lysosomal biogenesis, and ...
Man Zhu +12 more
wiley +1 more source
Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging
Aging Cell, EarlyView.The molecular underpinnings of divergent cognitive trajectories in aging remain unresolved. Using high‐resolution behavioral testing to cognitively stratify aged male mice into ‘intact’ and ‘impaired’ subgroups, we show that reactive gliosis and cellular senescence are key determinants of disparities in cognitive function with age.
Matthew P. Baier +9 more
wiley +1 more source
Aged Gut Microbiota Contributes to Cognitive Impairment and Hippocampal Synapse Loss in Mice
Aging Cell, EarlyView.Li et al. revealed that aged gut microbiota induces cognitive decline and microglia‐mediated synapse loss. Fecal Bifidobacterium pseudolongum abundance was reduced in patients with cognitive impairment and microbiota transplantation from patients with fewer B.p abundance yielded worse cognitive behavior in mice.
Mingxiao Li +12 more
wiley +1 more source
Aging Cell, EarlyView.Transcriptomic analyses reveal an age‐related decline in autophagy pathways in RPE/choroid. These pathways remain unchanged in early AMD but become bidirectionally dysregulated in later stages, along with increased RPE loss. Pre‐treatment with trehalose eyedrops enhances RPE autophagy flux and prevents light‐induced outer retinal degeneration in mice ...
Katherine Cox +13 more
wiley +1 more source
Circadian Gene BMAL1 Regulation of Cellular Senescence in Thyroid Aging
Aging Cell, EarlyView.BMAL1 downregulation during aging reduces NFKBIA expression, accelerating thyroid cellular senescence and impairing hormone synthesis. Circadian rhythm disruption exacerbates thyroid functional decline, highlighting the BMAL1‐NFKBIA axis as a key mediator of aging‐related thyroid dysfunction and offering insights for stabilizing thyroid health in aging
Dandan Zong +4 more
wiley +1 more source
Academic Emergency Medicine, Volume 32, Issue 4, Page 414-425, April 2025.Abstract Background The use of a computed tomography pulmonary angiogram to diagnose pulmonary embolism (PE) has increased, leading not only to higher PE diagnoses but also to overdiagnosis and unnecessary radiation exposure, even in young patients despite a lower PE incidence.
Thibaut Jossein +10 more
wiley +1 more source
Academic Emergency Medicine, Volume 32, Issue 3, Page 327-339, March 2025.Abstract Diagnostic errors in health care pose significant risks to patient safety and are disturbingly common. In the emergency department (ED), the chaotic and high‐pressure environment increases the likelihood of these errors, as emergency clinicians must make rapid decisions with limited information, often under cognitive overload.
R. Andrew Taylor +11 more
wiley +1 more source