Results 101 to 110 of about 485,259 (393)

DEC1 and DEC2 Crosstalk between Circadian Rhythm and Tumor Progression

open access: yesJournal of Cancer, 2016
Clock genes, major regulators of circadian rhythm, are involved in tumor progression. We have shown that clock genes basic helix-loop-helix (BHLH) transcription factors, differentiated embryonic chondrocyte gene 1 (DEC1/BHLHE40/Sharp2/Stra13) and DEC2 ...
F. Sato   +3 more
semanticscholar   +1 more source

Dual‐Crosslinked Betaine‐Based Amphiphilic Hydrogel as a Promising Vitreous Substitute: Anti‐Adhesion, Anti‐Fouling, and Anti‐Cell Proliferation

open access: yesAdvanced Science, EarlyView.
A novel multiple cross‐linked betaine‐type amphiphilic polymer hydrogels are developed via in situ free radical copolymerization. The resultant formation, named P(SBMA‐co‐AANa) hydrogel, functions as a vitreous substitute and demonstrates superior performance in optical properties, support capacity, and biocompatibility on a vitrectomized rabbit model.
Yuting Cai   +8 more
wiley   +1 more source

Research progress on correlation between circadian rhythm disturbance and work-related musculoskeletal disorders

open access: yes环境与职业医学
Circadian rhythm refers to the 24-hour periodic changes in behavior, physiology, and molecular processes in the human body. Disruptions to the circadian rhythm not only affect mental health but are also associated with various metabolic disorders ...
Lichong LAI   +5 more
doaj   +1 more source

On the Excretion of Urinary 17-Hydroxycorticosteroids (17-OHCS) in Antarctic Region [PDF]

open access: yes, 1976
In the study of the effect of chilliness and the tendency of cryodomestication, the urinary output of 17-Hydroxycorticosteroids (17-OHCS) was used, and its circadian rhythm was investigated.
Tetsuo Oda
core   +1 more source

At Least Four Distinct Circadian Regulatory Mechanisms Required for All Phases of Rhythms in mRNA Amount [PDF]

open access: yes, 2008
Since the advent of techniques to investigate gene expression on a large scale, numerous circadian rhythms in mRNA abundance have been reported. These rhythms generally differ in amplitude and phase. First studies on circadian rhythms of transcription on
Jacobshagen, Sigrid   +2 more
core   +3 more sources

Implications of Circadian Rhythm in Dopamine and Mood Regulation

open access: yesMolecules and Cells, 2017
Mammalian physiology and behavior are regulated by an internal time-keeping system, referred to as circadian rhythm. The circadian timing system has a hierarchical organization composed of the master clock in the suprachiasmatic nucleus (SCN) and local ...
Jeongah Kim   +5 more
semanticscholar   +1 more source

Circadian Rhythms in Plants [PDF]

open access: yesCold Spring Harbor Perspectives in Biology, 2019
The circadian oscillator is a complex network of interconnected feedback loops that regulates a wide range of physiological processes. Indeed, variation in clock genes has been implicated in an array of plant environmental adaptations, including growth regulation, photoperiodic control of flowering, and responses to abiotic and biotic stress.
Nicky M. Creux, Stacey L. Harmer
openaire   +3 more sources

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

open access: yesAdvanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao   +17 more
wiley   +1 more source

Modulatory effects in circadian-related diseases via the reciprocity of tea polyphenols and intestinal microbiota

open access: yesFood Science and Human Wellness, 2022
Tea is a widespread functional plant resource. Phytochemicals such as tea polyphenols (TP) can interact with the intestinal flora and participate in regulating the expression and rhythm of biological clock genes.
Ruonan Yan, Chi-Tang Ho, Xin Zhang
doaj  

Evaluation of QT Liability for PF‐05251749 in the Presence of Potential Circadian Rhythm Modification

open access: yesCPT: Pharmacometrics & Systems Pharmacology, 2020
PF‐05251749 is a dual inhibitor of casein kinase 1 δ/ε, key regulators of circadian rhythm. As a result of its mechanism of action, PF‐05251749 may also change the heart rate corrected QT (QTc) circadian rhythm, which may confound detection of drug ...
Yeamin Huh   +4 more
doaj   +1 more source

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