Results 21 to 30 of about 233 (72)

The RNA interactome in the Hallmarks of Cancer

WIREs RNA, Volume 14, Issue 5, September/October 2023., 2023
Interactions of RNA molecules play key roles across all Hallmarks of Cancer and were not captured by large genome sequencing efforts. These RNA interactomics provide novel insight into cancer initiation and progression, and provide novel therapeutic targets for treatment of cancers and many other diseases.
Marta M. Gabryelska, Simon J. Conn
wiley   +1 more source

Alternative splicing in bladder cancer: potential strategies for cancer diagnosis, prognosis, and treatment

WIREs RNA, Volume 14, Issue 3, May/June 2023., 2023
RNA splicing alteration is functionally linked to bladder cancer progression. Many players regulating the RNA splicing process (spliceosome components and splicing factors) and surrogate markers resulting from its alteration (mRNA splicing variants and ncRNAs) are drastically dysregulated in bladder cancer and play a pathophysiological role in this ...
Antonio J. Montero‐Hidalgo, Jesús M. Pérez‐Gómez, Antonio J. Martínez‐Fuentes, Enrique Gómez‐Gómez, Manuel D. Gahete, Juan M. Jiménez‐Vacas, Raúl M. Luque   +6 more
wiley   +1 more source

Recent development of urinary biomarkers for bladder cancer diagnosis and monitoring

Clinical and Translational Discovery, Volume 3, Issue 2, April 2023., 2023
A systematic overview of technical considerations in developping urine biomarkers. Seven classes of urine biomarkers are summarised for bladder cancer detection and monitoring. Highlight of limitations and future improvements. Abstract Urine‐based liquid biopsy has emerged as a non‐invasive and effective tool for early screening and diagnosis of ...
Yuchen Zeng, Anqi Wang, Wei Lv, Qingqing Wang, Shiqi Jiang, Xiaoguang Pan, Fei Wang, Huanming Yang, Lars Bolund, Chunhua Lin, Peng Han, Yonglun Luo   +11 more
wiley   +1 more source

Hsa_hsa_circ_0081069 promotes the progression of colorectal cancer through sponging miR‐665 and regulating E2F3 expression

Journal of Clinical Laboratory Analysis, Volume 36, Issue 11, November 2022., 2022
Circular RNAs (circRNAs) have been implicated tumor initiation and progression. This study explored the role of circ_0081069 in regulating the malignancy of colorectal cancer (CRC). Hsa_circ_0081069 is upregulated in CRC tissues and cell lines, and silencing has_circ_0081069 impairs the malignancy of CRC cells.
Jingjing Xie, Dan Jin, Jinyin Xu, Fei Yang, Jianying Jin   +4 more
wiley   +1 more source

eIF4A3‐induced circWAC promotes breast cancer progression through mediating miR‐599/E2F3 axis

The Kaohsiung Journal of Medical Sciences, Volume 38, Issue 4, Page 321-335, April 2022., 2022
Abstract Circular RNAs (circRNAs) are implicated in the regulation of tumor progression via the “competitive endogenous RNAs (ceRNAs)” mechanism. We intended to explore the molecular mechanism of circRNA WW domain containing adaptor with coiled‐coil (circWAC) in breast cancer (BC) progression.
Wen‐Hui Huang, Qing Yang, Chuan Zhang
wiley   +1 more source

hsa_circ_0000518 Facilitates Non‐Small‐Cell Lung Cancer Progression via Moderating miR‐330‐3p and Positively Regulating SLC1A5

Journal of Immunology Research, Volume 2022, Issue 1, 2022., 2022
Background/Aim. Non‐small‐cell lung cancer (NSCLC) is the principal agent of cancer deaths globally. The goal of this study was to determine how circular RNA_0000518 (circ_0000518) regulates tumor progression. Materials/Methods. circ_0000518 was selected as a study target involved in NSCLC from GEO (Gene Expression Omnibus) database. circ_0000518 level
Huilai Lv, Zhihua Shi, Aixia Sui, Yan Zhang, Liangbiao Peng, Mingbo Wang, Fan Zhang, Fu Wang   +7 more
wiley   +1 more source

Novel insights into exosomal circular RNAs: Redefining intercellular communication in cancer biology

Clinical and Translational Medicine, Volume 11, Issue 12, December 2021., 2021
Circular RNAs (circRNAs) can exert their functions via exosome delivery to recipient cells. Exosomal circRNAs are involved in tumour‐to‐tumour crosstalk, tumour‐to‐stroma crosstalk and stroma‐to‐tumour crosstalk in the tumour microenvironment. Exosomal circRNAs are promising diagnostic, prognostic and predictive biomarkers for cancer, and exosomes ...
Huimin Lin, Jie Yu, Xiang Gu, Shengfang Ge, Xianqun Fan   +4 more
wiley   +1 more source

circAMOTL1L Suppresses Renal Cell Carcinoma Growth by Modulating the miR‐92a‐2‐5p/KLLN Pathway

Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021
Accumulating evidence indicates that the dysregulation of circular RNAs (circRNAs) contributes to tumor progression; however, the regulatory functions of circRNAs in renal cell carcinoma (RCC) remain largely unknown. In this study, the function and underlying mechanism of circAMOTL1L in RCC progression were explored.
Ling Gao, Xian Shao, Qingqing Yue, Weifei Wu, Xuejuan Yang, Xiaolei He, Limin Li, Fujun Hou, Ruonan Zhang, Fabio Ciccarone   +9 more
wiley   +1 more source

Circ-PRMT5 enhances the proliferation, migration and glycolysis of hepatoma cells by targeting miR-188-5p/HK2 axis

Annals of Hepatology, 2020
Introduction and objectives: Circular RNA (circRNA) has been demonstrated as a critical regulator in human cancer, including hepatocellular carcinoma (HCC). Nevertheless, the role of circ-PRMT5 in HCC remains largely unknown.
Zhenghua Ding, Li Guo, Zhongming Deng, Peng Li   +3 more
doaj   +1 more source

Additional file 1 of Treatment of bladder cancer by geoinspired synthetic chrysotile nanocarrier-delivered circPRMT5 siRNA

, 2022
Additional file 1.
Yu, Chunping, Zhang, Yi, Wang, Ning, Wei, Wensu, Cao, Ke, Zhang, Qun, Ma, Peiying, Xie, Dan, Wu, Pei, Liu, Biao, Liu, Jiahao, Xiang, Wei, Hu, Xing, Liu, Xuewen, Xie, Jianfei, Tang, Jin, Long, Zhi, Wang, Long, Zeng, Hongliang, Liu, Jianye   +19 more
openaire   +1 more source