Circ-PRMT5 promotes gastric cancer progression by sponging miR-145 and miR-1304 to upregulate MYC
Artificial Cells, Nanomedicine, and Biotechnology, 2019 Background Gastric cancer (GC) is a global leading source of cancer-associated deaths. Circular RNAs (circRNAs) are a new type of non-coding RNA and promising biomarkers for diagnosis of multiple diseases such as cancer.Methods Circ-PRMT5 expression was ...
Wenbo Du +8 more
doaj +1 more source
Potential Role of Exosomes in Cancer Metastasis
BioMed Research International, Volume 2019, Issue 1, 2019., 2019 High cancer mortality is attributed to metastasis to a large extent. However, cancer metastasis remains devoid of dynamic monitoring and early prevention in terms of current advances in diagnostic means and therapeutic modalities. Meanwhile, studies have shown that reciprocal crosstalk among cells via exosomes plays a critical role in maintaining ...
Wenjuan Tian +3 more
wiley +1 more source
RNAs in tumour‐derived extracellular vesicles and their significance in the tumour microenvironment
International Journal of Cancer, Volume 155, Issue 7, Page 1147-1161, 1 October 2024.Abstract Small extracellular vesicles (sEVs) secreted by various types of cells serve as crucial mediators of intercellular communication within the complex tumour microenvironment (TME). Tumour‐derived small extracellular vesicles (TDEs) are massively produced and released by tumour cells, recapitulating the specificity of their cell of origin.
Maria Bugajova +5 more
wiley +1 more source
Intricate relationship between cancer stemness, metastasis, and drug resistance
MedComm, Volume 5, Issue 10, October 2024.Complexity of cancer stem cell biology and the intricate relationship between cancer stem cells, metastasis, and drug resistance Abstract Cancer stem cells (CSCs) are widely acknowledged as the drivers of tumor initiation, epithelial‐mesenchymal transition (EMT) progression, and metastasis. Originating from both hematologic and solid malignancies, CSCs
Tikam Chand Dakal +9 more
wiley +1 more source
Circular RNAs in human diseases
MedComm, Volume 5, Issue 9, September 2024.Circular RNAs (circRNAs) play significant roles in various human diseases, including respiratory, endocrine, metabolic, musculoskeletal, cardiovascular, renal diseases, and cancer. This review highlights their biogenesis, pathogenic potential, and potential applications as diagnostic biomarkers and therapeutic targets. Abstract Circular RNAs (circRNAs)
Yuanyong Wang +10 more
wiley +1 more source
circPRMT5通过靶向miR-98-5p对膀胱癌细胞增殖、迁移侵袭的机制研究
Zhongguo shiyan zhenduanxue目的 探究circPRMT5通过靶向miR-98-5p对膀胱癌细胞增殖、迁移侵袭的机制研究。方法 qRT-PCR检测永生化正常尿路上皮细胞SV-HUC-1和膀胱癌细胞(T24、J82、HT-1376)中circPRMT5、miR-98-5p和X染色体连锁的凋亡抑制蛋白(XIAP)mRNA相对表达水平。核糖核酸酶(RNase)R和放线菌素D的消化实验鉴定circPRMT5的环状结构。将T24细胞分为si-NC组、si-circPRMT5组、miR-NC组、miR-98-5p组、si-circPRMT5 ...
谢奕彪, 姜良真, 崔小健
doaj
circPRMT5通过靶向miR-98-5p对膀胱癌细胞增殖、迁移侵袭的机制研究 附视频
Zhongguo shiyan zhenduanxue目的 探究circPRMT5通过靶向miR-98-5p对膀胱癌细胞增殖、迁移侵袭的机制研究。方法 qRT-PCR检测永生化正常尿路上皮细胞SV-HUC-1和膀胱癌细胞(T24、J82、HT-1376)中circPRMT5、miR-98-5p和X染色体连锁的凋亡抑制蛋白(XIAP)mRNA相对表达水平。核糖核酸酶(RNase)R和放线菌素D的消化实验鉴定circPRMT5的环状结构。将T24细胞分为si-NC组、si-circPRMT5组、miR-NC组、miR-98-5p组、si-circPRMT5 ...
doaj +2 more sources
Circular RNAs in breast cancer diagnosis, treatment and prognosis. [PDF]
Oncol Res, 2023 Huang X, Song C, Zhang J, Zhu L, Tang H.
europepmc +1 more source
Unraveling the significance of exosomal circRNAs in cancer therapeutic resistance. [PDF]
Front Pharmacol, 2023 Kang F +6 more
europepmc +1 more source
Epithelial-mesenchymal transition-related circular RNAs in lung carcinoma. [PDF]
Cancer Biol Med, 2021 Jiang M, Fang S, Zhao X, Zhou C, Gong Z.
europepmc +1 more source