Results 41 to 50 of about 825,271 (288)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Impact of Frequency Heterogeneity on Mutually Synchronized Spatially Distributed 24 GHz PLLs

IEEE Open Journal of Circuits and Systems
This research analyzes the mutual self-organized synchronization of phase-locked loops (PLLs) in the presence of variations in the free-running frequency of a PLL.
Christian Hoyer, Jens Wagner, Frank Ellinger   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Modulation Bandwidth Investigation of Voltage-Controlled Oscillators Under Periodic Linear Frequency Modulation

IEEE Open Journal of Circuits and Systems
The modulation bandwidth of a voltage-controlled oscillator (VCO) is a key design metric that defines its ability to respond to fast tuning voltages and change its frequency accordingly. While prior works have addressed practical methods for measuring it,
Rabia Fatima Riaz, Ronny Henker, Frank Ellinger   +2 more
doaj   +1 more source

Automated analysis of connected speech reveals early biomarkers of Parkinson’s disease in patients with rapid eye movement sleep behaviour disorder

Scientific Reports, 2017
For generations, the evaluation of speech abnormalities in neurodegenerative disorders such as Parkinson’s disease (PD) has been limited to perceptual tests or user-controlled laboratory analysis based upon rather small samples of human vocalizations ...
Jan Hlavnička, Roman Čmejla, Tereza Tykalová, Karel Šonka, Evžen Růžička, Jan Rusz   +5 more
doaj   +1 more source

Hypernasality associated with basal ganglia dysfunction: evidence from Parkinson’s disease and Huntington’s disease [PDF]

PeerJ, 2016
Background Although increased nasality can originate from basal ganglia dysfunction, data regarding hypernasality in Parkinson’s disease (PD) and Huntington’s disease (HD) are very sparse.
Michal Novotný, Jan Rusz, Roman Čmejla, Hana Růžičková, Jiří Klempíř, Evžen Růžička   +5 more
doaj   +2 more sources

Electro-hydrodynamics of binary electrolytes driven by modulated surface potentials [PDF]

, 2005
We study the electro-hydrodynamics of the Debye screening layer that arises in an aqueous binary solution near a planar insulating wall when applying a spatially modulated AC-voltage.
A. Ajdari, H. Morgan, Henrik Bruus, Laurits Højgaard Olesen, Lionel Belmon, Niels Asger Mortensen, V. Studer   +6 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Microstrip-Based Anti-Aliasing Filters for Beyond-50 GHz-Bandwidth Mix-Filter-Sample Analog-to-Digital-Converters

IEEE Access
High performance anti-aliasing filters (AAF) are critical components of advanced frequency interleaved (FI) analog-to-digital converter (ADC) structures, which are capable of overcoming the sample-clock jitter limit for ultra-high speed power efficient ...
Anton Lorenz, Christian D. Matthus, Frank Ellinger   +2 more
doaj   +1 more source

New Discrete Fibonacci Charge Pump Design, Evaluation and Measurement

Measurement Science Review, 2017
This paper focuses on the practical aspects of the realisation of Dickson and Fibonacci charge pumps. Standard Dickson charge pump circuit solution and new Fibonacci charge pump implementation are compared.
Matoušek David, Hospodka Jiří, Šubrt Ondřej   +2 more
doaj   +1 more source