Results 1 to 10 of about 251,975 (292)
Circular Proteins from Plants and Fungi [PDF]
Journal of Biological Chemistry, 2012 Circular proteins, defined as head-to-tail cyclized polypeptides originating from ribosomal synthesis, represent a novel class of natural products attracting increasing interest. From a scientific point of view, these compounds raise questions of where and why they occur in nature and how they are formed.
Ulf Göransson +2 more
exaly +9 more sources
Thematic minireview series on circular proteins. [PDF]
J Biol Chem, 2012 Circular proteins have now been discovered in all kingdoms of life and are characterized by their exceptional stability and the diversity of their biological activities, primarily in the realm of host defense functions. This thematic minireview series provides an overview of the distribution, evolution, activities, and biological synthesis of circular ...
Craik DJ, Allewell NM.
europepmc +8 more sources
Chemical synthesis of circular proteins. [PDF]
J Biol Chem, 2012 Circular proteins, once thought to be rare, are now commonly found in plants. Their chemical synthesis, once thought to be difficult, is now readily achievable. The enabling methodology is largely due to the advances in entropic chemical ligation to overcome the entropy barrier in coupling the N- and C-terminal ends of large peptide segments for either
Tam JP, Wong CT.
europepmc +7 more sources
Cancer Informatics, 2014 Various studies have implicated different multidomain proteins in cancer. However, there has been little or no detailed study on the role of circular multidomain proteins in the general problem of cancer or on specific cancer types.
Donald Adjeroh +3 more
doaj +4 more sources
Circular proteins — no end in sight
Trends in Biochemical Sciences, 2002 Circular proteins are a recently discovered phenomenon. They presumably evolved to confer advantages over ancestral linear proteins while maintaining the intrinsic biological functions of those proteins. In general, these advantages include a reduced sensitivity to proteolytic cleavage and enhanced stability.
Manuela Trabi, David J Craik
exaly +7 more sources
Discovering the Bacterial Circular Proteins: Bacteriocins, Cyanobactins, and Pilins [PDF]
Journal of Biological Chemistry, 2012 Over recent years, several examples of natural ribosomally synthesized circular proteins and peptides from diverse organisms have been described. They are a group of proteins for which the precursors must be post-translationally modified to join the N ...
Manuel Montalbán-López +2 more
exaly +4 more sources
Circular proteins and mechanisms of cyclization
Biopolymers, 2010 AbstractCyclization via head‐to‐tail linkage of the termini of a peptide chain occurs in only a small percentage of proteins, but engenders the resultant cyclic proteins with exceptional stability. The mechanisms involved are poorly understood and this review attempts to summarize what is known of the events that lead to cyclization.
Brendon Conlan +2 more
exaly +8 more sources
Circular permutation of red fluorescent proteins.
PLoS ONE, 2011 Circular permutation of fluorescent proteins provides a substrate for the design of molecular sensors. Here we describe a systematic exploration of permutation sites for mCherry and mKate using a tandem fusion template approach.
Bo Shui +7 more
doaj +5 more sources
Circular dichroism spectroscopy of membrane proteins [PDF]
Chemical Society Reviews, 2016 Circular dichroism spectra of helical bundle (red), beta barrel (blue), and mixed helical/sheet/unordered (green) membrane proteins.
A J Miles, B A Wallace
exaly +5 more sources
Circular permutation in proteins. [PDF]
PLoS Computational Biology, 2012 The authors have declared that no competing interests exist. The RCSB PDB is managed by two members of the RCSB: Rutgers and UCSD, and is funded by National Science Foundation (NSF), National Institute of General Medical Sciences, Department of Energy (DOE), National Library of Medicine, National Cancer Institute, National Institute of ...
Spencer Bliven, Andreas Prlić
doaj +4 more sources