Results 71 to 80 of about 297,585 (294)

RNA-based liquid biopsies for better clinical management of Barrett’s esophagus and esophageal adenocarcinoma [PDF]

, 2019
In the past decades the incidence of esophageal adenocarcinoma (EAC) has increased dramatically in most Western populations. Due to the lack of symptoms EAC is often detected in a late stage, contributing to a poor 5-year survival rate.
De Preter, Katleen, Depypere, Lieven, Nafteux, Philippe, Pattyn, Piet, Philippron, Annouck, Schoofs, Kathleen, Vandesompele, Jo   +6 more
core  

BATCH-GE : batch analysis of next-generation sequencing data for genome editing assessment [PDF]

, 2016
Targeted mutagenesis by the CRISPR/Cas9 system is currently revolutionizing genetics. The ease of this technique has enabled genome engineering in-vitro and in a range of model organisms and has pushed experimental dimensions to unprecedented proportions.
Boel, Annekatrien, Callewaert, Bert, Coucke, Paul, De Paepe, Anne, De Rocker, Nina, Menten, Björn, Steyaert, Wouter, Willaert, Andy   +7 more
core   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Construction of transcriptional regulatory networks using total RNA-seq data

STAR Protocols, 2021
Summary: Total RNA sequencing allows capturing of long non-coding and circular RNA along with mRNA. Additional sequencing of micro RNA (miRNA), using libraries with shorter fragments, provides the means to characterize miRNA-driven transcriptional ...
Philippe Chouvarine, Georg Hansmann
doaj   +1 more source

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations. [PDF]

, 2019
Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; ncontrol = 13; nAD = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC).
Bateman, Randall J, Budde, John P, Chhatwal, Jasmeer P, Cruchaga, Carlos, Del-Aguila, Jorge L, Dominantly Inherited Alzheimer Network (DIAN), Dube, Umber, Farias, Fabiana, Fernandez, Maria Victoria, Gentsch, Jen, Graff-Radford, Neill R, Harari, Oscar, Hsu, Simon, Ibanez, Laura, Jiang, Shan, Karch, Celeste M, Lee, Jae-Hong, Li, Zeran, Masters, Colin L, Morris, John C, Norton, Joanne, Salloway, Stephen, Wang, Fengxian   +22 more
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Circular RNA Expression Profile in Cervical Cancer and Construction of the Circular RNA‑MicroRNA‑Messenger RNA Regulatory Network

Креативная хирургия и онкология
Introduction. Cervical cancer (CC) remains the most common cancer in women worldwide. However, effective and specific biomarkers for the diagnosis and prognosis of cervical cancer are yet to be found.
S. A. Begliarzade, R. I. Tamrazov, E. R. Musaev, C. Wang   +3 more
doaj   +1 more source

Hybrids of RNA viruses and viroid-like elements replicate in fungi

Nature Communications, 2023
Earth’s life may have originated as self-replicating RNA, and it has been argued that RNA viruses and viroid-like elements are remnants of such pre-cellular RNA world. RNA viruses are defined by linear RNA genomes encoding an RNA-dependent RNA polymerase
Marco Forgia, Beatriz Navarro, Stefania Daghino, Amelia Cervera, Andreas Gisel, Silvia Perotto, Dilzara N. Aghayeva, Mary F. Akinyuwa, Emanuela Gobbi, Ivan N. Zheludev, Robert C. Edgar, Rayan Chikhi, Massimo Turina, Artem Babaian, Francesco Di Serio, Marcos de la Peña   +15 more
doaj   +1 more source

Research progress on circular RNA vaccines

Frontiers in Immunology, 2023
Owing to the success of linear mRNA coronavirus disease 2019 (COVID-19) vaccines, biopharmaceutical companies and research teams worldwide have attempted to develop more stable circular RNA (circRNA) vaccines and have achieved some preliminary results ...
Yu Bai, Yu Bai, Yu Bai, Dong Liu, Dong Liu, Dong Liu, Qian He, Qian He, Qian He, Jianyang Liu, Jianyang Liu, Jianyang Liu, Qunying Mao, Qunying Mao, Qunying Mao, Zhenglun Liang, Zhenglun Liang, Zhenglun Liang   +17 more
doaj   +1 more source

Hyb:A bioinformatics pipeline for the analysis of CLASH (crosslinking, ligation and sequencing of hybrids) data [PDF]

, 2013
Peer reviewedPublisher ...
Aiba, Aleksandra Helwak, Altschul, Anthony J. Travis, Aravin, Chi, Chi, David Tollervey, Dodt, Field, Filipowicz, Gong, Granneman, Grzegorz Kudla, Hafner, Hansen, Helwak, Jonathan Moody, Kent, Kim, Kudla, Langmead, Leung, Licatalosi, Lorenz, Markham, Memczak, Quinlan, Rost, Simpson, Ule, Wlotzka, Zhang   +32 more
core   +2 more sources