Results 211 to 220 of about 2,013,218 (333)

Circular RNAs: Key Regulators of Tumor Metabolic Reprogramming and Clinical Translation. [PDF]

Oncol Res
Wu Y, Liu Y, Sun R, Zhang Y, Zhang Q, Li C, Li M.   +6 more
europepmc   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Recent Studies on Kaposi's Sarcoma-Associated Herpesvirus Circular RNAs. [PDF]

Cancers (Basel)
Pagtalunan CJ, Zhang I, Turley A, Liu F.
europepmc   +1 more source

Analysis of circZNF609: a multifunctional circular RNA with oncogenic properties

reservedCircular RNAs (circRNAs) are a peculiar class of stable RNAs that have a covalently closed loop structure originated from a noncanonical splicing event (back-splicing), characterized by the lack of 5’ and 3’ ends.
CONTE, EMMA
core  

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Construction and Brain Validation of circRNAs-miRNAs-mRNAs Regulatory Axis in Early-Onset Schizophrenia

Neuropsychiatric Disease and Treatment
Xiuping Zhang,1,2,* Zexuan Li,3,4,* Ruiting Li,5,* Xinxia Wang,1 Huanghui Liu,1 Xinzhe Du,1,4 Yao Gao,1,4 Sha Liu,1,4 Yong Xu1,3,4 1Department of Psychiatry, Shanxi Medical University, Taiyuan, People’s Republic of China ...
Zhang X, Li Z, Li R, Wang X, Liu H, Du X, Gao Y, Liu S, Xu Y   +8 more
doaj  

Simultaneous Study of Circular RNAs and Messenger RNAs in Colorectal Cancer: The Unbalanced Fate of a Couple? [PDF]

Cancers (Basel)
Levacher C, Delfosse J, Charbonnier C, Charbonnier F, Viennot M, Kasper E, Mauillon J, Parodi N, Baert-Desurmont S, Ruminy P, Houdayer C.   +10 more
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

The emerging role of circular RNAs in neuropsychiatric disorders. [PDF]

Transl Psychiatry
Huang S, Song Z, Pan J, Luo Y, Chen Y.
europepmc   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source