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Decoupling transcriptome layers: the distinct and variable nature of circular RNAs. [PDF]

open access: yesBMC Biol
Alonso-García M   +7 more
europepmc   +1 more source
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Circular RNA Databases

2021
Circular RNAs (circRNAs) are a class of endogenous ncRNAs with covalently closed-loop structures, lacking of 5' caps and 3' tails. These novel ncRNAs are ubiquitously expressing in eukaryotes, exhibiting expression patterns of specific cell types, tissues, or developmental stages.
Peijing, Zhang, Ming, Chen
openaire   +2 more sources

Circular RNAs in cholangiocarcinoma

Cancer Letters, 2023
Cholangiocarcinoma (CCA) is the most common primary biliary malignancy with an adverse prognosis. Although its incidence is relatively low, early diagnosis is difficult due to the lack of specific symptoms. Current treatment options for CCA are limited, resulting in a low curative rate.
Wenwei Liao   +5 more
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Circular RNAs in atherosclerosis

Clinica Chimica Acta, 2022
Atherosclerosis (AS) is a chronic inflammatory lesion of the arterial vessel wall caused by a variety of complex factors. Furthermore, it is a major cause of cardiovascular disease and a leading cause of death. Circular RNAs (circRNAs) are a new family of endogenous non-coding RNAs with unique covalently closed loops that have sparked interest due to ...
Xiaoni, Huang   +3 more
openaire   +2 more sources

Circular RNA in Exosomes

2018
Circular RNAs (circRNAs) are a novel family of non-coding endogenous RNAs discovered in all eukaryotic cells and generated through a particular mechanism of alternative splicing called "back-splicing". These molecules show multiple functions, by acting as modulators of gene and miRNA expression, and may have a role in several biological processes, such
Daniele Fanale   +3 more
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Circular RNA Splicing

2018
Circular RNAs (circRNAs) are covalently closed single-stranded RNA molecules derived from exons by alternative mRNA splicing. Circularization of single-stranded RNA molecules was already described in 1976 for viroids in plants. Since then several additional types of circular RNAs in many species have been described such as the circular single-stranded ...
Nicole, Eger   +4 more
openaire   +2 more sources

Circular RNAs and cancer

Cancer Letters, 2017
Circular RNAs (circRNAs) are a type of non-coding RNA molecules that lack a 5'-terminal cap and 3'-terminal poly A tail. A large number of circRNAs have been identified through biological experiments, computational methods and high-throughput sequencing. CircRNA sequence composition determines if a given circRNA is exonic, intronic or retained-intronic.
Jun He   +4 more
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Circular RNAs in Blood

2018
Recent advances in RNA sequencing and bioinformatic analysis have allowed the development of a new research field: circular RNAs (circRNAs). These members of the non-coding transcriptome are generated by backsplicing, which results in a covalently closed, single-stranded RNA molecule.
Vea, A   +2 more
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Circular RNAs in Cancer

2018
Circular RNAs (circRNAs) constitute a class of RNAs that only recently have come into the focus of the scientific cancer community after it was revealed that they are very abundant, highly conserved across species and show tissue- and developmental stage-specific expression. This tightly regulated, dynamic circRNA expression, in line with expression of
Susanne, Lux, Lars, Bullinger
openaire   +2 more sources

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