Results 271 to 280 of about 981,735 (367)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Characterization of Circulating Endothelial Cells in Acute Myocardial Infarction

Science Translational Medicine, 2012
Samir B. Damani, A. Bacconi, Ondrej Libiger, Aparajita H Chourasia, R. Serry, Raghava R. Gollapudi, R. Goldberg, K. Rapeport, Sharon Haaser, Sarah E. Topol, S. Knowlton, K. Bethel, P. Kuhn, M. Wood, B. Carragher, N. Schork, John X Jiang, C. Rao, M. Connelly, V. Fowler, E. Topol   +20 more
semanticscholar   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Circulating endothelial cells and their progenitors in acute myeloid leukemia. [PDF]

Oncol Lett, 2016
Zahran AM, Aly SS, Altayeb HA, Ali AM.
europepmc   +1 more source

Increase in Circulating Endothelial Progenitor Cells by Statin Therapy in Patients With Stable Coronary Artery Disease

Circulation, 2001
M. Vasa, S. Fichtlscherer, K. Adler, A. Aicher, H. Martin, A. Zeiher, S. Dimmeler   +6 more
semanticscholar   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Circulating endothelial cells and risk of progression in patients with hepatocellular cancer receiving sorafenib. [PDF]

Hepat Oncol, 2017
Giovanis P, Pianezze G, Vincenzi V, Manuppelli C, Boaretto M, Pastorelli D.   +5 more
europepmc   +1 more source

Role of circulating endothelial progenitor cells in the reparative mechanisms of stable ischemic myocardium

, 2017
Doralisa Morrone, Francesca Felice, Cristian Scatena, Andrea De Martino, M.L.E. Picoi, Niccolò Mancini, Sara Blasi, Michele Menicagli, R. Di Stefano, Uberto Bortolotti, Antonio Giuseppe Naccarato, Alberto Balbarini   +11 more
openalex   +2 more sources

C-reactive protein induces release of both endothelial microparticles and circulating endothelial cells in vitro and in vivo: further evidence of endothelial dysfunction.

Clinical Chemistry, 2011
S. Devaraj, P. Kumaresan, I. Jialal
semanticscholar   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source