Results 91 to 100 of about 367,441 (304)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Plasma protein profiling reveals protein clusters related to BMI and insulin levels in middle-aged overweight subjects [PDF]

, 2010
Biomarkers that allow detection of the onset of disease are of high interest since early detection would allow intervening with lifestyle and nutritional changes before the disease is manifested and pharmacological therapy is required. Our study aimed to
Edith J M Feskens, van Dijk, S.J., Rest, O., van de, Heidema A. Geert, Edith J. M. Feskens, Heidema, A.G., Johanna M Geleijnse, Geleijnse, J.M., Geleijnse Johanna M., de Groot, Lisette C. P. G. M., Müller, M.R., van Dijk Susan J., Bos Marieke B., Lisette C P G M de Groot, Heidema, A. Geert, Geleijnse, Johanna M., Afman Lydia A., van de Rest, O., Feskens Edith J. M., Feskens, Edith J. M., Lydia A Afman, Afman, Lydia A., Johanna M. Geleijnse, Müller, Michael, Müller Michael, Bos, M.B., A Geert Heidema, Bos, Marieke B., Susan J. van Dijk, Afman, L.A., Michael Müller, van Dijk, Susan J., van de Rest, Ondine, Lisette C. P. G. M. de Groot, Lydia A. Afman, Feskens, E.J.M., Marieke B Bos, A. Geert Heidema, Marieke B. Bos, Susan J van Dijk, van de Rest Ondine, Dijk, S.J., van, Ondine van de Rest, de Groot Lisette C. P. G. M.   +43 more
core   +1 more source

Circulating Calreticulin Is Increased in Myelofibrosis: Correlation with Interleukin-6 Plasma Levels, Bone Marrow Fibrosis, and Splenomegaly

Mediators of Inflammation, 2016
Myelofibrosis (MF) is a clonal neoplasia of the hemopoietic stem/progenitor cells associated with genetic mutations in the Janus kinase 2 (JAK2), myeloproliferative leukemia virus oncogene (MPL), and calreticulin (CALR) genes. MF is also characterized by
Daria Sollazzo, Dorian Forte, Nicola Polverelli, Margherita Perricone, Marco Romano, Simona Luatti, Nicola Vianelli, Michele Cavo, Francesca Palandri, Lucia Catani   +9 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Natural history and outcome in systemic AA amyloidosis [PDF]

, 2007
BACKGROUND:Deposition of amyloid fibrils derived from circulating acute-phase reactant serum amyloid A protein (SAA) causes systemic AA amyloidosis, a serious complication of many chronic inflammatory disorders.
Goodman, HJB, Lachmann, HJ, Gillmore, JD, Hawkins, PN, Gilbertson, JA, Gallimore, JR, Sabin, CA   +6 more
core  

Neutrophil extracellular traps in inflammatory disorders [PDF]

, 2014
A novel feature of polymorphonuclear granulocyte (PMN) biology is their ability to generate neutrophil extracellular traps (NETs) via a distinct process of cell death termed NETosis.
Sur Chowdhury, Chanchal
core   +1 more source

Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease

Mediators of Inflammation, 2016
Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal.
Senthooran Selvarajah, Ian Todd, Patrick J. Tighe, Michelle John, Charlotte E. Bolton, Timothy Harrison, Lucy C. Fairclough   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Increased circulating ANG II and TNF-α represents important risk factors in obese Saudi adults with hypertension irrespective of diabetic status and BMI [PDF]

, 2012
Central adiposity is a significant determinant of obesity-related hypertension risk, which may arise due to the pathogenic inflammatory nature of the abdominal fat depot.
Bindahman, Lotfi S., Mohamed, Amany O., Draz Hossam M., Saleem, Tahia H., Alkharfy Khalid M., Lotfi S Bindahman, Mohamed Amany O., Omar S Al-Attas, Alokail, Majed S., Al-Attas, Omar S., Al-Attas Omar S., Philip G McTernan, Al-Daghri, Nasser M., Tahia H Saleem, Amany O Mohamed, Hossam M Draz, Harte Alison L., Majed S Alokail, Alison L Harte, Saleem Tahia H., Yakout Sobhy, Harte, Alison L., Al-Daghri Nasser M., Alokail Majed S., Nasser M Al-Daghri, McTernan Philip G., Bindahman Lotfi S., Yakout, Sobhy M., Draz, Hossam M., Alkharfy, Khalid M., McTernan, P. G. (Philip G.), Sobhy Yakout, Khalid M Alkharfy   +32 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source