Results 81 to 90 of about 367,441 (304)

Mendelian randomization analysis of causal and druggable circulating inflammatory proteins in schizophrenia

Frontiers in Psychiatry
BackgroundSchizophrenia (SZ) is a severe mental disorder with complex origins. Observational studies suggested that inflammatory factors may play a role in the pathophysiology of SZ and we aim to investigate the potential genetic connection between them by examining the causal impact of circulating inflammatory proteins on SZ.MethodsWe utilized ...
Hongbao Cao, Li Fu, Dongming Liu, Ancha Baranova, Ancha Baranova, Fuquan Zhang, Fuquan Zhang   +6 more
openaire   +3 more sources

Pro- and anti-inflammatory cytokines in threatened miscarriages [PDF]

, 2011
OBJECTIVE: The purpose of this study was to evaluate circulating and intracellular levels of Th1 and Th2 cytokines in women with threatenedmiscarriage (TM) and subsequent outcome.
Jean Calleja-Agius, Arnold R. Pizzey, Calleja-Agius, Jean, Jauniaux, Eric R.M., Shanthi Muttukrishna, Eric Jauniaux, Muttukrishna, Shanthi, Pizzey, Arnold R.   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Association between circulating inflammatory proteins and gout: A Mendelian randomization study

Medicine
Clinical studies have consistently demonstrated that inflammation is a critical factor in the pathophysiology and progression of gout. This study aims to explore the causal relationship between CIPs and gout, utilizing MR in conjunction with meta-analyses.
Xiaochao Xie, Yanjie Song, Wenwen Chen, Hui Zhao, Nan Chu, Fang Wang   +5 more
openaire   +2 more sources

APOE polymorphism and its effect on plasma C-reactive protein levels in a large general population sample [PDF]

, 2010
The literature on association between apolipoprotein E (APOE) gene variations and plasma levels of C-reactive protein (CRP) remains inconsistent, mainly due to low statistical power of previous studies.
Pikhart, H., Peasey, Anne, Pikhart, Hynek, Stavek, Petr, Hubacek, J.A., Kubinova, R., Marmot, Michael, Kubinova, Ruzena, Peasey, A., Hubacek, Jaroslav A., Marmot, M., Stavek, P., Bobak, Martin, Bobak, M.   +13 more
core   +1 more source

Proteomic Profile of the ICAM1 p.K56M HFpEF Risk Variant

JACC: Basic to Translational Science
Summary: A common missense variant in ICAM1 among African American individuals (rs5491; pK56M) has been associated with risk of heart failure with preserved ejection fraction (HFpEF), but the pathways that lead to HFpEF among those with this variant are ...
Pedro Giro, MD, Mallory Filipp, PhD, Michael J. Zhang, MD, PhD, Ethan D. Moser, MPH, Edward B. Thorp, PhD, Prarthana J. Dalal, MD, PhD, Ravi V. Shah, MD, Patrick T. Ellinor, MD, PhD, Jonathan W. Cunningham, MD, Sean J. Jurgens, MD, MSc, Arjun Sinha, MD, MSc, Laura Rasmussen-Torvik, PhD, MPH, Jorge Kizer, MD, MSc, Kent D. Taylor, PhD, Philip Greenland, MD, Bruce M. Psaty, MD, PhD, Russell P. Tracy, PhD, Lin Yee Chen, MD, MS, Amil M. Shah, MD, Bing Yu, PhD, Sanjiv J. Shah, MD, Ravi B. Patel, MD, MSc   +21 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Causal insights into multiple myeloma: The impact of circulating inflammatory proteins and metabolites

Medicine
Multiple myeloma (MM) is a heterogeneous hematologic malignancy characterized by high recurrence rates and incurability despite therapeutic advances. Emerging evidence implicates circulating inflammatory proteins, plasma metabolites, and leukocyte characteristics in MM pathogenesis, though their specific causal roles remain unclear.
Pengfei Zhang, Haoying Li, Yijia Huang, Hao Sha   +3 more
openaire   +2 more sources

HbA1c levels and circulating inflammatory proteins at onset of type 1 diabetes in children and adolescents

Journal of Diabetes & Metabolic Disorders, 2022
Abstract Purpose Type 1 diabetes is an autoimmune disease that often develops during childhood. Complications such as retinopathy often occur during the course of the disease. Studies to identify possible predictors of complications in type 1 diabetes are needed; in particular markers able to identify risk of ...
Jonatan Dereke, Charlotta Nilsson
openaire   +2 more sources

Therapeutic potential of Cistanche against Parkinson's disease via regulating circulating inflammation: Insights from Mendelian randomization, molecular docking, and in vivo studies

Experimental Gerontology
Background: Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, and no curative treatment is currently available.
Haixin Liu, Yue Chen, Chenyue Li, Qiaofeng Zhang, Xinpei Lin, Yao Lin, Qian Xu   +6 more
doaj   +1 more source