Results 71 to 80 of about 367,441 (304)

Assessment of causality between circulating inflammatory proteins and subtypes of diabetic retinopathy

International Journal of Ophthalmology
AIM: To explore the causal links among circulating inflammatory proteins (CIPs) and the varying severities of diabetic retinopathy (DR). METHODS: This research utilized a two sample Mendelian randomization (MR) approach to explore the causal relationships between 91 CIPs and various severities of DR: background DR (BDR) or non-proliferative DR (NPDR ...
Dong, Min, Zhang, Ning-Zhi, Cao, Wen-Ye, Deng, Xiao-Xi, Zhang, Wen-Xi, Xing, Yi-Qiao, Yang, Ning   +6 more
openaire   +2 more sources

Reduction of circulating cholesterol and apolipoprotein levels during sepsis [PDF]

, 1999
Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered ...
Peter Fraunberger, Karl Werdan, Werdan, Karl, Walli, Autar K., Autar K. Walli, Dietrich Seidel, Seidel, Dietrich, Steffen Schaefer, Fraunberger, Peter, Schaefer, Steffen   +9 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Genetic causality of circulating inflammatory proteins and plasma metabolites in coronary atherosclerosis

Postgraduate Medical Journal
Abstract Background Coronary atherosclerosis is a leading cause of cardiovascular disease and death worldwide. Despite progress in understanding its pathogenesis, the roles of circulating inflammatory proteins and plasma metabolites are complex and not fully elucidated.
Runji, Chen, Daifei, Shen, Shiwan, Wu, Yanhong, Zhang, Shu, Ye   +4 more
openaire   +2 more sources

Causal effects of inflammatory cytokines on cardiovascular diseases: Insights from genetic evidence

Heliyon
Background: The causal relationship between inflammatory cytokines and cardiovascular diseases (CVDs) has not been fully elucidated. Exploring this relationship between circulating inflammatory cytokines and CVDs is crucial for early clinical diagnosis ...
Yuxiu Chen, Aifang Zhong
doaj   +1 more source

Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins on cardiovascular and non-cardiovascular outcomes

Communications Medicine, 2023
Schmidt et al. evaluate the effects of elevated circulating concentrations of cholesterol-containing lipoproteins and apolipoproteins. Effects are seen on measures of atherosclerosis, blood pressure, c-reactive protein, coronary heart disease, heart ...
Amand F. Schmidt, Roshni Joshi, Maria Gordillo-Marañón, Fotios Drenos, Pimphen Charoen, Claudia Giambartolomei, Joshua C. Bis, Tom R. Gaunt, Alun D. Hughes, Deborah A. Lawlor, Andrew Wong, Jackie F. Price, Nishi Chaturvedi, Goya Wannamethee, Nora Franceschini, Mika Kivimaki, Aroon D. Hingorani, Chris Finan   +17 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Rheumatoid Arthritis, Circulating Inflammatory Proteins, and Hypertension: A Mendelian Randomization Study

The Journal of Clinical Hypertension
ABSTRACTObservational studies have indicated that there is an association between rheumatoid arthritis (RA) and an elevated risk of hypertension. However, a definitive causal relationship between the two conditions has not been established. The objective of this study was to investigate the causal link between RA and hypertension, as well as the ...
Guobing Jia, Tao Guo, Lei Liu, Chengshi He   +3 more
openaire   +3 more sources

Socioeconomic inequalities in coronary heart disease risk in older age: contribution of established and novel coronary risk factors [PDF]

, 2009
Background: Evidence on socioeconomic inequalities in coronary heart disease (CHD) and their pathways in the elderly is limited. Little is also known about the contributions that novel coronary risk factors (particularly inflammatory/hemostatic markers ...
Morris, RW, R. W. MORRIS, Whincup, PH, Papacosta, O, Lennon, L., G. LOWE, O. PAPACOSTA, Lowe, G., Rumley, A., A. RUMLEY, S. G. WANNAMETHEE, Whincup, P. H., Ramsay, S. E., Wannamethee, SG, Morris, R. W., P. H. WHINCUP, Lowe, G.D., Papacosta, O., Wannamethee, S. G., S. E. RAMSAY, Ramsay, SE, Rumley, A, Lennon, L, L. LENNON, Lowe, G   +24 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source