Results 41 to 50 of about 52,419 (242)

Discovery of novel targets for multi-epitope vaccines: Screening of HIV-1 genomes using association rule mining

Retrovirology, 2009
Background Studies have shown that in the genome of human immunodeficiency virus (HIV-1) regions responsible for interactions with the host's immune system, namely, cytotoxic T-lymphocyte (CTL) epitopes tend to cluster together in relatively conserved ...
Piontkivska Helen, Paul Sinu
doaj   +1 more source

MOLECULAR EPIDEMIOLOGICAL ANALYSIS OF HIV INFECTION IN NORTHERN SEAPORTS OF RUSSIA

Вопросы вирусологии, 2017
The results of the molecular-epidemiological analysis of HIV-1 variants circulating in Arkhangelsk and Murmansk - northern seaports of Russia - were presented. In these seaports the HIV-1 variants belonging to subtype A1 were predominant (93% in Murmansk,
E. V. Kazennova, V. Yu. Laga, K. B. Gromov, M. N. Sankov, E. S. Popova, E. G. Lgumnova, E. N. Oparina, T. A. Sorokina, M. R. Bobkova   +8 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Identification and characterization of an emerging small ruminant lentivirus circulating recombinant form (CRF)

Virology, 2015
The molecular epidemiology of small ruminant lentiviruses (SRLVs) is constantly changing due to animal movements, cross species transmission and because of their rapid evolutionary rate. This study reports a comprehensive genetic and phylogenetic analysis based on consensus gag and pol sequences covering 3kb of the SRLV genome from small ruminants in ...
L’Homme, Yvan, Leboeuf, Anne, Arsenault, Julie, Fras, Marion   +3 more
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Genome Sequences of a Novel HIV-1 Circulating Recombinant Form, CRF55_01B, Identified in China [PDF]

Genome Announcements, 2013
ABSTRACT We report here a novel HIV-1 circulating recombinant form (CRF55_01B) composed of CRF01_AE and subtype B, with four recombination breakpoints in the pol gene. CRF55_01B was identified from three epidemiologically unlinked men having sex with men (MSM) in China, suggesting the ongoing generation of
Han, Xiaoxu, An, Minghui, Zhang, Weiqing, Cai, Weiping, Chen, Xi, Takebe, Yutaka, Shang, Hong   +6 more
openaire   +2 more sources

Molecular Epidemiology of HIV-1 Subtype G in the Russian Federation

Viruses, 2019
Although HIV-1 subtype A has predominated in Russia since the end of the 20th century, other viral variants also circulate in this country. The dramatic outbreak of HIV-1 subtype G in 1988-1990 represents the origin of this variant spreading in Russia ...
Anastasia Murzakova, Dmitry Kireev, Pavel Baryshev, Alexey Lopatukhin, Ekaterina Serova, Andrey Shemshura, Sergey Saukhat, Dmitry Kolpakov, Anna Matuzkova, Alexander Suladze, Marina Nosik, Vladimir Eremin, German Shipulin, Vadim Pokrovsky   +13 more
doaj   +1 more source

Molecular Epidemiological Analysis of the Origin and Transmission Dynamics of the HIV-1 CRF01_AE Sub-Epidemic in Bulgaria

Viruses, 2021
HIV-1 subtype CRF01_AE is the second most predominant strain in Bulgaria, yet little is known about the molecular epidemiology of its origin and transmissibility.
Ivailo Alexiev, Ellsworth M. Campbell, Sergey Knyazev, Yi Pan, Lyubomira Grigorova, Reneta Dimitrova, Aleksandra Partsuneva, Anna Gancheva, Asya Kostadinova, Carole Seguin-Devaux, Ivaylo Elenkov, Nina Yancheva, William M. Switzer   +12 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Characterization of New Recombinant Forms of HIV-1 From the Comunitat Valenciana (Spain) by Phylogenetic Incongruence

Frontiers in Microbiology, 2019
Recombination is one of the main processes shaping the evolution of HIV-1, with relevant consequences for its epidemiology. In fact, Circulating and Unique Recombinant Forms (CRFs and URFs) cause 23% of current infections.
Beatriz Beamud, Beatriz Beamud, María Alma Bracho, María Alma Bracho, María Alma Bracho, Fernando González-Candelas, Fernando González-Candelas, Fernando González-Candelas   +7 more
doaj   +1 more source