Results 261 to 270 of about 493,161 (298)

HDAC inhibitor tucidinostat and metronomic capecitabine plus endocrine therapy for patients with HR-positive HER2-negative advanced breast cancer after CDK4/6 inhibitors treatment: clinical findings and exploratory circulating tumor cell and ctDNA biomarker analyses of a multicenter, phase 2 study (SYSUCC-020 trial). [PDF]

Signal Transduct Target Ther
Wu HL, Xia W, Xu Z, Zhou H, Chen L, Lu Y, Liu X, Pang D, Liu Y, Lu Q, Xu F, An X, Huang J, Jiang K, Zhang J, Cai Y, Hong R, Zheng Q, Wang S.   +18 more
europepmc   +1 more source

Digoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial. [PDF]

Nat Med
Kurzeder C, Nguyen-Sträuli BD, Krol I, Ring A, Castro-Giner F, Nüesch M, Asawa S, Zhang YW, Budinjas S, Gvozdenovic A, Vogel M, Kohler A, Grašič Kuhar C, Schwab FD, Heinzelmann-Schwarz V, Weber WP, Rochlitz C, Vorburger D, Frauchiger-Heuer H, Witzel I, Wicki A, Kuster GM, Vetter M, Aceto N.   +23 more
europepmc   +1 more source

Pre-treatment Circulating Tumor Cell Associated White Blood Cell Clusters Independently Predict Poor Survival in Patients with Extensive-disease Small Cell Lung Cancer. [PDF]

Biomark Insights
Wang Y, Zhang M, Chen C, Liu Y, Gao Y, Li H, Lu B, Hu M, Zhang H, Lin PP, Ren Z, Zhang T, Xu S.   +12 more
europepmc   +1 more source

Developing a prognostic risk model based on circulating tumor cell genes to predict prognosis and provide potential therapeutic strategies in colorectal cancer. [PDF]

Transl Cancer Res
Zheng Y, Yang M, Yi H, Peng T, Sun J, Yu J.   +5 more
europepmc   +1 more source

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Circulating Tumor Cells

Materials and Methods, 2017
In most solid tumors, it is distant metastases rather than the primary tumor which limit the prognosis. Distant metastases are caused by circulating tumor cells (CTCs) which actively invade the blood stream, attach to the endothelium in the target organ, invade the surrounding parenchyma, and form new tumors.
Sebastián A, García, Jürgen, Weitz, Sebastian, Schölch   +2 more
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Circulating Tumor Cells and Circulating Tumor DNA

Annual Review of Medicine, 2012
Solid tumors derived from epithelial tissues (carcinomas) are responsible for 90% of all new cancers in Europe, and the main four tumor entities are breast, prostate, lung, and colon cancer. Present tumor staging is mainly based on local tumor extension, metastatic lymph node involvement, and evidence of overt distant metastasis obtained by imaging ...
Catherine, Alix-Panabières, Heidi, Schwarzenbach, Klaus, Pantel   +2 more
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Circulating Tumor Cells Revisited

JAMA, 2010
DESPITE THE USE OF MODERN HIGH-RESOLUTION imaging technologies, it is not possible to detect tumor cell metastasis at a single cell level. To date, cancer treatment is initiated only after the clinical presentation of disease. This approach generally is unsuccessful and translates into the dogma that metastasis is a terminal process, generally viewed ...
Massimo, Cristofanilli, Stephan, Braun
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Circulating Tumor Cells

Molecular Diagnosis & Therapy, 2012
Circulating tumor cells (CTCs) are cells of presumed epithelial origin, whose prognostic and predictive value in metastatic cancer patients has recently been demonstrated. To date, the count of CTCs through the CellSearch® system represents a valid approach for monitoring disease status in patients with metastatic colorectal, breast, and prostate ...
GAZZANIGA, PAOLA, RAIMONDI, CRISTINA, GRADILONE, Angela, NASO, Giuseppe, CORTESI, Enrico, FRATI, Luigi   +5 more
openaire   +3 more sources

Tumor heterogeneity and circulating tumor cells

Cancer Letters, 2016
In patients with cancer, individualized treatment strategies are generally guided by an analysis of molecular biomarkers. However, genetic instability allows tumor cells to lose monoclonality and acquire genetic heterogeneity, an important characteristic of tumors, during disease progression.
Chufeng Zhang, Yan Guan, Yulan Sun, Dan Ai, Qisen Guo   +4 more
openaire   +2 more sources