Results 31 to 40 of about 461,371 (240)

The biology of circulating tumor cells [PDF]

Oncogene, 2015
Metastasis is a biologically complex process consisting of numerous stochastic events which may tremendously differ across various cancer types. Circulating tumor cells (CTCs) are cells that are shed from primary tumors and metastatic deposits into the blood stream.
K Pantel, M R Speicher
openaire   +2 more sources

Application of circulating tumor cells scope technique on circulating tumor cell research [PDF]

Molecular and Cellular Therapies, 2014
Circulating tumor cells (CTCs) are becoming promising biomarkers in several cancers, such as colon, prostate, and breast carcinomas. Independent research groups have reported a correlation between CTC numbers and patient prognosis. Even more, the development of personalized medicine gives physicians impetus to utilize the advancement of molecular ...
Xiaochen Tian, Lijie Wang, Dawei Yang
openaire   +3 more sources

Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy. [PDF]

, 2017
Current cell-free DNA (cfDNA) next generation sequencing (NGS) precision oncology workflows are typically limited to targeted and/or disease-specific applications.
Alva, Ajjai S, Brockman, Scott, Chinnaiyan, Arul M, Chugh, Rashmi, Feng, Felix Y, Grasso, Catherine S, Gursky, Amy, Haakenson, Christine, Henderson, James, Herman, Kirk, Hovelson, Daniel H, Husain, Hatim, Hussain, Maha H, Kamberov, Emmanuel, Kandarpa, Malathi, Kang, Qing, Krauss, John C, Langmore, John, Liu, Chia-Jen, Lonigro, Robert J, Mills, Ryan E, Morgan, Todd M, Quist, Michael J, Ramnath, Nithya, Robinson, Dan, Smith, David C, Talpaz, Moshe, Tesmer, Tim, Tewari, Muneesh, Tomlins, Scott A, Tuck, Missy, Wang, Yugang   +31 more
core   +1 more source

Plasma next generation sequencing and droplet digital PCR‐based detection of epidermal growth factor receptor (EGFR) mutations in patients with advanced lung cancer treated with subsequent‐line osimertinib

Thoracic Cancer, 2019
Background Gene mutation analysis from plasma circulating tumor DNA (ctDNA) can provide timely information regarding the mechanism of resistance that could translate to personalised treatment.
Pei N. Ding, Therese Becker, Victoria Bray, Wei Chua, Yafeng Ma, Bo Xu, David Lynch, Paul de Souza, Tara Roberts   +8 more
doaj   +1 more source

Algorithm to identify circulating tumor cell clusters using in vivo flow cytometer [PDF]

Journal of Innovative Optical Health Sciences, 2018
Recent studies in oncology have addressed the importance of detecting circulating tumor cell clusters because circulating tumor cell clusters might survive and metastasize more easily than single circulating tumor cells.
Kai Pang, Dan Wei, Pengfei Hai, Zhangru Yang, Xiaofu Weng, Xunbin Wei   +5 more
doaj   +1 more source

Circulating Tumor Cell Composition in Renal Cell Carcinoma. [PDF]

PLoS ONE, 2016
PURPOSE:Due to their minimal-invasive yet potentially current character circulating tumor cells (CTC) might be useful as a "liquid biopsy" in solid tumors. However, successful application in metastatic renal cell carcinoma (mRCC) has been very limited so
Ivonne Nel, Thomas C Gauler, Kira Bublitz, Lazaros Lazaridis, André Goergens, Bernd Giebel, Martin Schuler, Andreas-Claudius Hoffmann   +7 more
doaj   +1 more source

Circulating tumor cells isolation: The “post-EpCAM era” [PDF]

, 2015
Circulating tumor cells (CTCs) represent a submicroscopic fraction detached from a primary tumor and in transit to a secondary site. The prognostic significance of CTCs in metastatic cancer patients was demonstrated for the first time more than ten years
Gradilone, Angela, Nicolazzo, Chiara, Raimondi, Cristina   +2 more
core   +1 more source

Longitudinal Study of Circulating Biomarkers in Patients with Resectable Pancreatic Ductal Adenocarcinoma

Biosensors, 2022
While patients with resectable pancreatic ductal adenocarcinoma (PDAC) show improved survival compared to their non-resectable counterparts, survival remains low owing to occult metastatic disease and treatment resistance.
Pablo J. Dopico, Minh-Chau N. Le, Benjamin Burgess, Zhijie Yang, Yu Zhao, Youxiang Wang, Thomas J. George, Z. Hugh Fan   +7 more
doaj   +1 more source

Circulating tumor cells: Ready for translation? [PDF]

Journal of Experimental Medicine, 2020
Circulating tumor cells are tumor-derived pioneers responsible for the metastatic spread of cancer. Here, we outline recent discoveries, challenges, and future trends for circulating tumor cell investigations, arguing that the time is coming for translation of this work into clinical practice.
Nicola Aceto, Zoi Diamantopoulou, Francesc Castro-Giner, Francesc Castro-Giner   +3 more
openaire   +4 more sources

Prognostic and predictive value of circulating tumor cells and CXCR4 expression as biomarkers for a CXCR4 peptide antagonist in combination with carboplatin-etoposide in small cell lung cancer: exploratory analysis of a phase II study. [PDF]

, 2017
Background Circulating tumor cells (CTCs) and chemokine (C-X-C motif) receptor 4 (CXCR4) expression in CTCs and tumor tissue were evaluated as prognostic or predictive markers of CXCR4 peptide antagonist LY2510924 plus carboplatin-etoposide (CE) versus ...
Baeten, Kurt, Connelly, Mark C, D'Haese, David, Flynt, Amy, Gross, Steve, McCleod, Michael, Morano, Carrie, Peek, Victoria L, Polzer, John, Raddad, Eyas, Repollet, Madeline, Roberson, Stephanie, Salgia, Ravi, Sanders, Renouard, Spigel, David R, Stille, John R, Um, Suzane L, Weaver, R Waide, Wijayawardana, Sameera R, Yan, S Betty   +19 more
core   +1 more source