Results 101 to 110 of about 6,850,236 (255)

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Lymph‐circulating tumor cells show distinct properties to blood‐circulating tumor cells and are efficient metastatic precursors

Molecular Oncology, 2019
The leading cause of breast cancer‐associated death is metastasis. In 80% of solid tumors, metastasis via the lymphatic system precedes metastasis via the vascular system.
Sulma I. Mohammed, Odalys Torres‐Luquis, Elwood Walls, Frank Lloyd   +3 more
doaj   +1 more source

Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth [PDF]

, 2009
Background: Anti-cancer chemotherapy can be simultaneously lymphodepleting and immunostimulatory. Pre-clinical models clearly demonstrate that chemotherapy can synergize with immunotherapy, raising the question how the immune system can be mobilized to ...
Amy Prosser, Robinson, B.W.S., Currie, A.J., Scalzo, A.A., Joanne Salmons, Robbert G van der Most, Mark J Smyth, Bruce W S Robinson, Salmons, J., Lake, R.A., Smyth Mark J., Andrew J Currie, Amanda L Cleaver, Prosser, Amy, van der Most, R.G., Degli-Esposti, M.A., Salmons, Joanne, Lake, Richard A., Prosser, A., Prosser Amy, Nowak, A.K., Currie, Andrew J., van der Most Robbert G., Smyth, M.J., Robinson Bruce W. S., Lake Richard A., Degli-Esposti, Mariapia A., Scalzo Anthony A., Currie Andrew J., Nowak, Anna K., Sathish Mahendran, Cleaver, Amanda L., Richard A Lake, Nowak Anna K., van der Most, Robbert G., Larma, I., Mahendran, S., Anna K Nowak, Degli-Esposti Mariapia A., Anthony A Scalzo, Cleaver, A.L., Robinson, Bruce W.S., Larma, Irma, Irma Larma, Cleaver Amanda L., Smyth, Mark J., Larma Irma, Mehendran, Sathish, Scalzo, Anthony A., Salmons Joanne, Mahendran Sathish, Mariapia A Degli-Esposti   +51 more
core   +2 more sources

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Size-Based and Non-Affinity Based Microfluidic Devices for Circulating Tumor Cell Enrichment and Characterization

, 2016
Circulating Tumor Cells (CTCs) are tumor cells found in cancer patients’ peripheral blood. Enumeration of CTCs can provide prognosis information for cancer management (Cristofanilli et al., N Engl J Med 351(8):781–791, 2004; Cohen et al., J Clin Oncol 26(
Richard J. Cote, Cote, Richard J, Zheng Ao, Datar, Ram H, Kamran Moradi, Moradi, Kamran, Ram H. Datar, Ao, Zheng   +7 more
core   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

PillarX: A Microfluidic Device to Profile Circulating Tumor Cell Clusters Based on Geometry, Deformability, and Epithelial State

, 2022
Circulating tumor cell (CTC) clusters are associated with increased metastatic potential and worse patient prognosis, but are rare, difficult to count, and poorly characterized biophysically.
Gunby RH, Marazzini M, Magni S, Labib M, Scita G., Martini E, Frittoli E, Lobefaro R, Maiuri P, Fiore PPD, Vernieri C, Pisati F, Sigismund S, Kelley SO, Fardin A, Wang Z, Parazzoli D, Disanza A, Hershey B, Havas K, Li Q, Green BJ, Giangreco G, Marchesi S, Beznoussenko GV   +24 more
core   +1 more source

Circulating tumor cells and clusters as liquid biomarkers for the diagnosis and prognosis of neuroblastoma

BMC Cancer
The clinical significance of circulating tumor cell (CTC) clusters in highly metastatic tumors hasn't yet been revealed. Here, we demonstrated the diagnostic and prognostic value of CTC clusters in neuroblastoma (NB) which is the most prevalent childhood extracranial solid tumor.We employed cascaded filter deterministic lateral displacement ...
Xu, Huanli, Cao, Nianhua, Dai, Wenyan, Sima, Caiwei, Yi, Meng, Chen, Senmin, Chen, Xiaowen, Liu, Chao, Yu, Uet, Lang, Huiping, Zhou, Zhedie, Yang, Nanlin, Wang, Chunjing, Jiang, Xianping, Gan, Yungen, Wang, Jianyao, Wang, Yuanxiang, Yao, Nuaner, Xiao, Lidan, Zhang, Qing, Sun, Junjie, Lin, Zhou, Zhang, Gongwei, Zhang, Jiayue, Feng, Hongtao, Song, Jianming, Liu, Sixi, Liu, Zongbin, Wen, Feiqiu, Yuan, Xiuli   +29 more
openaire   +2 more sources

Small cell carcinoma of the endometrium: A case report with circulating tumor cell clusters

Frontiers in Laboratory Medicine, 2017
Abstract Primary small cell carcinoma (SCC) of the endometrium is a rare neuroendocrine tumor with aggressive behavior and poor prognosis, and no effective therapeutic method and prognosis monitoring were established. Circulating tumor cell (CTC) clusters have been asscociated with increasing metastatic potential and poor prognosis in malignant tumor.
Yongpeng He, Hai Huang, Haixia Wang, Lin Yi, Yichao Chen, Haiwei Zhang, Jing Ran, Hesong Shen, Qingming Jiang, Weiqi Nian   +9 more
openaire   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source