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Circulating Tumor Cell Cluster Sorting by Size and Asymmetry
2023Circulating tumor cell (CTC) clusters are rare yet potent initiators of metastasis and may be useful as clinical biomarkers. Numerous techniques have been developed to isolate individual circulating tumor cells from the blood, but these techniques are often ineffective at capturing CTC clusters and may cause cluster damage or dissociation during ...
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Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding [PDF]
Cell, 2019 The ability of circulating tumor cells (CTCs) to form clusters has been linked to increased metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain largely unknown. Here, we profile the DNA methylation landscape of single CTCs and CTC clusters from breast cancer patients and mouse models on a genome-wide scale.
Christian Beisel +2 more
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Abstract IA009: Biology and vulnerabilities of circulating tumor cell clusters
Cancer Research, 2023Abstract The metastatic spread of cancer occurs through the generation and hematogenous dissemination of circulating tumor cells (CTCs). Among these, CTC clusters have recently emerged as key players in the metastatic process. With a combination of microfluidic technologies and single cell-resolution molecular analysis applied to cancer ...
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En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition
Trends in Cancer, 2015Blood-borne metastasis accounts for the vast majority of cancer-related deaths and it is fueled by the generation of circulating tumor cells (CTCs) from a primary tumor deposit. Recent technological advances have made it possible to characterize human CTCs as they travel within the bloodstream.
Nicola, Aceto +3 more
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Circulating tumor cell clusters-associated gene plakoglobin and breast cancer survival
Breast Cancer Research and Treatment, 2015Breast cancer recurrence is a major cause of the disease-specific death. Circulating tumor cells (CTCs) are negatively associated with breast cancer survival. Plakoglobin, a cell adhesion protein, was recently reported as a determinant of CTCs types, single or clustered ones.
Lingeng, Lu +3 more
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Isolation and Genomic Analysis of Circulating Tumor Cell Clusters in Cancer Patients
The role of circulating tumor cell (CTC) clusters in the metastatic dissemination process is gaining increased attention. Besides homotypic clusters, heterotypic clusters that contain tumor cells admixed with normal cells are frequently observed in patients with solid tumors.Carolina, Reduzzi +6 more
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Clustered Circulating Tumor Cells as a Predictor of Adjuvant-chemotherapy Efficacy in Lung Cancer
The Annals of Thoracic SurgerySurrogate markers of minimal residual disease primarily include cell-free tumor DNA and circulating tumor cells. Cell-free tumor DNA might aid precise decision-making regarding who should receive adjuvant chemotherapy. However, there are no relevant reports on circulating tumor cells.
Noiyoshi Sawabata +4 more
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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Heather Parsons +2 more
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