Results 51 to 60 of about 5,339,936 (244)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Mapping breast cancer therapy with circulating tumor cells: The expert perspective

Breast
Circulating tumor cells (CTCs) have emerged as a key prognostic biomarker for breast cancer, with their role becoming more pronounced in metastatic cases.
Lorenzo Gerratana, Caterina Gianni, Eleonora Nicolò, Letizia Pontolillo, Francois-Clement Bidard, Carolina Reduzzi, Massimo Cristofanilli   +6 more
doaj   +1 more source

Bring along your friends: Homotypic and heterotypic circulating tumor cell clustering to accelerate metastasis

Biomedical Journal, 2020
Metastasis formation is a hallmark of invasive cancers and it is achieved through the shedding of circulating tumor cells (CTCs) from the primary site into the blood circulation.
Nicola Aceto
doaj   +1 more source

Association of a novel circulating tumor DNA next-generating sequencing platform with circulating tumor cells (CTCs) and CTC clusters in metastatic breast cancer. [PDF]

Breast Cancer Res, 2019
Abstract Purpose Liquid biopsies, including circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs), can be used to understand disease prognosis, tumor heterogeneity, and dynamic response to treatment in metastatic breast cancer (MBC).
Davis AA, Zhang Q, Gerratana L, Shah AN, Zhan Y, Qiang W, Finkelman BS, Flaum L, Behdad A, Gradishar WJ, Platanias LC, Cristofanilli M.   +11 more
europepmc   +5 more sources

Size-Based and Non-Affinity Based Microfluidic Devices for Circulating Tumor Cell Enrichment and Characterization

, 2016
Circulating Tumor Cells (CTCs) are tumor cells found in cancer patients’ peripheral blood. Enumeration of CTCs can provide prognosis information for cancer management (Cristofanilli et al., N Engl J Med 351(8):781–791, 2004; Cohen et al., J Clin Oncol 26(
Richard J. Cote, Cote, Richard J, Zheng Ao, Datar, Ram H, Kamran Moradi, Moradi, Kamran, Ram H. Datar, Ao, Zheng   +7 more
core   +1 more source

EpCAM-independent capture of circulating tumor cells with a ‘universal CTC-chip’

Oncology Reports, 2016
Capture of circulating tumor cells (CTCs), which are shed from the primary tumor site and circulate in the blood, remains a technical challenge. CellSearch® is the only clinically approved CTC detection system, but has provided only modest sensitivity in detecting CTCs mainly because epithelial cell adhesion molecule (EpCAM)-negative tumor cells may ...
Yasuhiro, Chikaishi, Kazue, Yoneda, Takashi, Ohnaga, Fumihiro, Tanaka   +3 more
openaire   +3 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Single-cell analyses of circulating tumor cells

Cancer Biology & Medicine, 2015
Circulating tumor cells (CTCs) are a population of tumor cells mediating metastasis, which results in most of the cancer related deaths. The number of CTCs in the peripheral blood of patients is rare, and many platforms have been launched for detection ...
Xi-Xi Chen, Fan Bai
doaj   +1 more source

Circulating tumor cells (CTCs) during TISOC1 treatment.

, 2015
Circulating tumor cells (CTCs) during TISOC1 treatment.
Andreas Dietz (771782), Holger Sudhoff (109301), Katharina Pachmann (15479), Claus Wittekindt (771784), Nicole Rotter (443924), Johannes Veit (443922), Viola Stemmann (771780), Katrin Oertel (771779), Christian Junghanß (5664487), Martin Görner (771783), Harald Schmalenberg (771781), Johanna Inhestern (771778), Orlando Guntinas-Lichius (771785)   +12 more
core   +1 more source