Results 61 to 70 of about 448,681 (368)

Splenomegaly in predicting the survival of patients with advanced primary liver cancer treated with immune checkpoint inhibitors

Cancer Medicine, Volume 11, Issue 24, Page 4880-4888, December 2022., 2022
Kaplan–Meier analysis demonstrated that patients with splenomegaly had worse OS than those without splenomegaly. Abstract Background & aims Immune checkpoint inhibitors (ICIs) play an increasingly important role in the treatment of primary liver cancer (PLC). Some patients with PLC experience symptoms of splenomegaly.
Lu‐Shan Xiao, Cheng‐Yi Hu, Hao Cui, Rui‐Ning Li, Chang Hong, Qi‐Mei Li, Chao‐Yi Huang, Zhong‐Yi Dong, Hong‐Bo Zhu, Li Liu   +9 more
wiley   +1 more source

Enhancement Pattern Mapping for Detection of Hepatocellular Carcinoma in Patients with Cirrhosis [PDF]

arXiv, 2023
Background and Aims: Limited methods exist to accurately characterize risk of malignant progression of liver lesions in patients undergoing surveillance for hepatocellular carcinoma (HCC). Enhancement pattern mapping (EPM) measures voxel-based root mean square deviation (RMSD) and improves the contrast-to-noise ratio (CNR) of liver lesions on standard ...
arxiv  

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

The risk of bleeding and encephalopathy in surgical patients with liver cirrhosis [PDF]

, 2019
Liver cirrhosis is a disease with an increasing incidence. Surgical procedures in patients with cirrhosis are also increasing, due to a longer life expectancy in these patients and also to the improvement of therapeutic and diagnostic resources ...
Bacalbașa, Nicolae, Banu, Petrișor, Bălălău, Cristian, Ghinghină, Octav, Gălățeanu, Bianca, Merlo, Emanuele Maria, Muscatello, Maria Rosaria Anna, Negrei, Carolina, Păunica, Ioana, Settineri, Salvatore   +9 more
core   +1 more source

Natural history of patients with non cirrhotic portal hypertension: Comparison with patients with compensated cirrhosis [PDF]

, 2018
Background. The knowledge of natural history of patients with portal hypertension (PH) not due to cirrhosis is less well known than that of cirrhotic patients. Aim.
Aprile, Francesca, Gioia, Stefania, Merli, Manuela, Nardelli, Silvia, Nicoletti, Valeria, Pasquale, Chiara, Pentassuglio, Ilaria, Riggio, Oliviero   +7 more
core   +1 more source

Pregnancy and cirrhosis [PDF]

Liver Transplantation, 2008
As the treatment of cirrhosis improves, pregnancy in patients with cirrhosis is likely to become more common. Although maternal and fetal mortality is expected to similarly improve, pregnant patients with cirrhosis face unique risks. These include higher rates of spontaneous abortion and prematurity and a potential for life-threatening variceal ...
Sammy Saab, Bijal Surti, Jennifer A. Tan
openaire   +3 more sources

Incidence of and Risk of Mortality After Hip Fractures in Rheumatoid Arthritis Relative to the General Population

Arthritis Care &Research, EarlyView.
Objective Osteoporosis, a known complication of rheumatoid arthritis (RA), increases the risk of hip fracture, which is associated with high morbidity and mortality. Fracture risk estimates in patients with RA treated with contemporary treatment strategies are lacking.
C. Allyson Jones, Pierre Guy, Hui Xie, Eric C. Sayre, Kai Zhao, Diane Lacaille   +5 more
wiley   +1 more source

Specific issues concerning the management of patients on the waiting list and after liver transplantation [PDF]

, 2018
The present document is a second contribution collecting the recommendations of an expert panel of transplant hepatologists appointed by the Italian Association for the Study of the Liver (AISF) concerning the management of certain aspects of liver ...
Burra, Patrizia, Caraceni, Paolo, Ferri, Flaminia, Giannini, Edoardo G, Ginanni Corradini, Stefano, Group, 1, Group, 2, Merli, Manuela., Rendina, Maria, Toniutto, Pierluigi, Volpes, Riccardo   +10 more
core   +1 more source

Considering the Risks and Costs of Solid Organ Xenotransplantation

Advanced Biology, EarlyView.
This perspective discusses the rationale, risks, and costs of whole‐organ xenotransplantation. It considers alternative strategies to obviate the demand for transplants and optimize allotransplantation systems and practices that do not impose xenotransplantation's harms and risks, and whether they are the most ethical and effective means to increase ...
Catharine E. Krebs, Janine McCarthy, Kristie Sullivan, James Craner, Brendan Parent, Ann Lam   +5 more
wiley   +1 more source

The clinicopathological significance and relapse predictive role of tumor microenvironment of intrahepatic cholangiocarcinoma after radical surgery

Cancer, Volume 129, Issue 3, Page 393-404, 1 February 2023., 2023
Abstract Background This study attempts to detect the expression of FoxP3, CD68, CD8α, and PD‐L1 in the tumor microenvironment (TME) of intrahepatic cholangiocarcinoma (ICC), and analyze the relationship between the corresponding cells and clinicopathological characteristics as well as prognosis of ICC.
Yiling Zheng, Ning Huang, Shuwen Kuang, Jing Zhang, Hong Zhao, Jianxiong Wu, Mei Liu, Liming Wang   +7 more
wiley   +1 more source