Results 91 to 100 of about 4,619 (224)

Unveiling the Differences of Secretome of Human Bone Marrow Mesenchymal Stem Cells, Adipose Tissue-Derived Stem Cells, and Human Umbilical Cord Perivascular Cells: A Proteomic Analysis [PDF]

, 2016
The use of human mesenchymal stem cells (hMSCs) has emerged as a possible therapeutic strategy for CNS-related conditions. Research in the last decade strongly suggests that MSC-mediated benefits are closely related with their secretome.
Anjo, Sandra, Gomes, Eduardo Domingos Correia, Manadas, Bruno, Pinheiro, Bárbara Filipa Mendes, Pires, Ana O., Ribeiro-Samy, Silvina, Salgado, A. J., Serra, Sofia Cravino, Silva, Nuno André Martins, Sousa, Nuno, Teixeira, Fábio Gabriel Rodrigues   +10 more
core   +1 more source

Quantitative Succinylacetone Measurement by Gas Chromatography‐Tandem Mass Spectrometry (GC–MS/MS) Facilitates Diagnosis, Monitoring, and Characterization of Tyrosinemia Type 1 and Other Hypersuccinylacetonemias

JIMD Reports, Volume 67, Issue 2, March 2026.
ABSTRACT Tyrosinemia type 1 (HT1), due to deficient activity of fumarylacetoacetate hydrolase, causes accumulation of succinylacetone (SA). SA concentrations in urine and plasma of untreated HT1 patients are typically several thousand‐fold higher than normal, hence are readily recognized by traditional diagnostic methods in most cases.
Denis Cyr, Bruno Maranda, Paula J. Waters   +2 more
wiley   +1 more source

Structural and Functional Analysis of the C-Terminal Domain of Nup358/RanBP2 [PDF]

, 2013
The nuclear pore complex is the sole mediator of bidirectional transport between the nucleus and cytoplasm. Nup358 is a metazoan-specific nucleoporin that localizes to the cytoplasmic filaments and provides several binding sites for the mobile ...
Hoelz, André, Lin, Daniel H., Stuwe, Evelyn, Stuwe, Tobias, Zimmermann, Stephan   +4 more
core   +2 more sources

Recent Advancements in the Characterization of D‐Amino Acid and Isoaspartate Post‐Translational Modifications

Mass Spectrometry Reviews, Volume 45, Issue 2, Page 218-230, March/April 2026.
ABSTRACT One of the great triumphs of mass spectrometry‐based peptide and protein characterization is the characterization of their modifications as most modifications have a characteristic mass shift. What happens when the modification does not change the mass of the peptide?
Samuel Okyem, Jonathan V. Sweedler
wiley   +1 more source

Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis

Cells, 2019
Hepatic fibrosis can result as a pathological response to nonalcoholic steatohepatitis (NASH). Cirrhosis, the late stage of fibrosis, has been linked to poor survival and an increased risk of developing hepatocellular carcinoma, with limited treatment ...
Sonia Simón Serrano, Alvar Grönberg, Lisa Longato, Krista Rombouts, Joseph Kuo, Matthew Gregory, Steven Moss, Eskil Elmér, Giuseppe Mazza, Philippe Gallay, Massimo Pinzani, Magnus J. Hansson, Ramin Massoumi   +12 more
doaj   +1 more source

In vivo bioassay to test the pathogenicity of missense human AIP variants [PDF]

, 2018
Background Heterozygous germline loss-of-function mutations in the aryl hydrocarbon receptor-interacting protein gene (AIP) predispose to childhood-onset pituitary tumours.
Aflorei, Elena Daniela, Chen, Chenghao, Dragu, Anca Neluta, Klapholz, Benjamin, Korbonits, Marta, Moderau, Nina, Prodromou, Chrisostomos, Radian, Serban, Ribeiro, Paulo S, Stanewsky, Ralf   +9 more
core   +1 more source

Ciclosporina: Riscos em Idade Pediátrica [PDF]

, 2010
Introdução: A eficácia e segurança da ciclosporina têm sido demonstradas em patologias inflamatórias dermatológicas, nomeadamente psoríase e eczema, em adultos e crianças. Na idade pediátrica o seu uso é no entanto ainda limitado.
Antunes, J, Brito, MJ, Gouveia, C
core  

Assessment of stress tolerance acquisition in the heat-tolerant derivative strains of Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus rhamnosus GG [PDF]

, 2017
[Aims] The purpose of this study was to investigate the heat-shock response at molecular level in Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp.
Aakko, J., Gueimonde Fernández, Miguel, Salminen, Seppo, Sánchez García, Borja   +3 more
core   +1 more source

Human cyclophilin 40 unravels neurotoxic amyloids.

PLoS Biology, 2017
The accumulation of amyloidogenic proteins is a pathological hallmark of neurodegenerative disorders. The aberrant accumulation of the microtubule associating protein tau (MAPT, tau) into toxic oligomers and amyloid deposits is a primary pathology in ...
Jeremy D Baker, Lindsey B Shelton, Dali Zheng, Filippo Favretto, Bryce A Nordhues, April Darling, Leia E Sullivan, Zheying Sun, Parth K Solanki, Mackenzie D Martin, Amirthaa Suntharalingam, Jonathan J Sabbagh, Stefan Becker, Eckhard Mandelkow, Vladimir N Uversky, Markus Zweckstetter, Chad A Dickey, John Koren, Laura J Blair   +18 more
doaj   +1 more source

Roles of Prolyl Isomerases in RNA-Mediated Gene Expression

Biomolecules, 2015
The peptidyl-prolyl cis-trans isomerases (PPIases) that include immunophilins (cyclophilins and FKBPs) and parvulins (Pin1, Par14, Par17) participate in cell signaling, transcription, pre-mRNA processing and mRNA decay.
Roopa Thapar
doaj   +1 more source