Results 101 to 110 of about 4,619 (224)

Native State Proline Isomerization:  An Intrinsic Molecular Switch [PDF]

, 2003
Exquisite control of biological function is achieved via tight regulation of the catalytic and binding activities of cellular proteins. The mechanistic details of protein regulation vary from targeted chemical modification of amino acid side chains (1 ...
Andreotti, Amy, Andreotti, Amy
core   +3 more sources

Cyclophilin inhibition as a strategy for the treatment of human disease

Frontiers in Pharmacology
Cyclophilins (Cyps), characterized as peptidyl-prolyl cis-trans isomerases (PPIases), are highly conserved and ubiquitous, playing a crucial role in protein folding and cellular signaling. This review summarizes the biochemical pathways mediated by Cyps,
Winston T. Stauffer, Asha Z. Goodman, Philippe A. Gallay   +2 more
doaj   +1 more source

FK506 Binding Protein Mediates Glioma Cell Growth and Sensitivity to Rapamycin Treatment by Regulating NF-κB Signaling Pathway

Neoplasia: An International Journal for Oncology Research, 2008
FK506 binding protein 5 (FKBP5) belongs to a family of immunophilins named for their ability to bind immunosuppressive drugs, also known as peptidyl-prolyl cis-trans isomerases, and also with chaperones to help protein folding.
Wei Jiang, Simona Cazacu, Cunli Xiang, Jean C Zenklusen, Howard A Fine, Michael Berens, Brock Armstrong, Chaya Brodie, Tom Mikkelsen   +8 more
doaj   +1 more source

Human Cytomegalovirus Encoded miR-US25-1-5p Attenuates CD147/EMMPRIN-Mediated Early Antiviral Response. [PDF]

, 2017
Cellular receptor-mediated signaling pathways play critical roles during the initial immune response to Human Cytomegalovirus (HCMV) infection.
Chen, Huizi, Chen, Jun, Chen, Zhinan, Li, Fanni, LIU, Fenyong, Xia, Sisi, Yang, Xiangmin   +6 more
core   +2 more sources

Enzymes: An integrated view of structure, dynamics and function [PDF]

, 2006
Microbes utilize enzymes to perform a variety of functions. Enzymes are biocatalysts working as highly efficient machines at the molecular level. In the past, enzymes have been viewed as static entities and their function has been explained on the basis ...
PratulK Agarwal
core   +2 more sources

In silico analysis of the cyclophilin repertoire of apicomplexan parasites

Parasites & Vectors, 2009
Background Cyclophilins (Cyps) are peptidyl cis/trans isomerases implicated in diverse processes such as protein folding, signal transduction, and RNA processing.
von Samson-Himmelstjerna Georg, Greif Gisela, Krücken Jürgen   +2 more
doaj   +1 more source

Pleiotropic Clostridioides difficile Cyclophilin PpiB Controls Cysteine-Tolerance, Toxin Production, the Central Metabolism and Multiple Stress Responses

Frontiers in Pharmacology, 2019
The Gram-positive pathogen Clostridioides difficile is the main bacterial agent of nosocomial antibiotic associated diarrhea. Bacterial peptidyl-prolyl-cis/trans-isomerases (PPIases) are well established modulators of virulence that influence the outcome
Can Murat Ünal, Can Murat Ünal, Mustafa Safa Karagöz, Mareike Berges, Mareike Berges, Christina Priebe, José Manuel Borrero de Acuña, Josef Wissing, Josef Wissing, Lothar Jänsch, Lothar Jänsch, Dieter Jahn, Dieter Jahn, Michael Steinert, Michael Steinert, Michael Steinert   +15 more
doaj   +1 more source

Genome-Wide Identification of the FKBP Gene Family in Rice and Its Potential Roles in Blast Resistance

Agronomy
Rice (Oryza sativa L.) is a major global staple crop, yet its productivity is severely constrained by rice blast disease caused by Magnaporthe oryzae.
Jiazong Liu, Xin Wang, Wendi Li, Qiyue Xu, Xinhua Ding, Ziyi Yin   +5 more
doaj   +1 more source

Editorial: Phosphorylation-Dependent Peptidyl-Prolyl Cis/Trans Isomerase PIN1 [PDF]

Frontiers in Cell and Developmental Biology, 2020
Jormay Lim, Tae Ho Lee, Futoshi Suizu
openaire   +3 more sources

Identification of Substrates of Cytoplasmic Peptidyl-Prolyl Cis/Trans Isomerases and Their Collective Essentiality in Escherichia Coli. [PDF]

Int J Mol Sci, 2020
Klein G, Wojtkiewicz P, Biernacka D, Stupak A, Gorzelak P, Raina S.   +5 more
europepmc   +1 more source