Results 51 to 60 of about 4,619 (224)
Target cell cyclophilins facilitate human papillomavirus type 16 infection. [PDF]
PLoS Pathogens, 2009 Following attachment to primary receptor heparan sulfate proteoglycans (HSPG), human papillomavirus type 16 (HPV16) particles undergo conformational changes affecting the major and minor capsid proteins, L1 and L2, respectively.
Malgorzata Bienkowska-Haba +2 more
doaj +1 more source
The SlyD metallochaperone targets iron-sulfur biogenesis pathways and the TCA cycle
mBio, 2023 Control of protein folding is a conserved function in all domains of life. The ubiquitous peptidyl-prolyl cis-trans isomerases (PPIases) catalyze the cis/trans-isomerization of peptidyl-prolyl bonds, often a rate-limiting step for protein folding ...
Milica Denic +5 more
doaj +1 more source
FRET-Protease-Coupled Peptidyl-Prolyl cis-trans Isomerase Assay [PDF]
SLAS Discovery, 2016 In this work, a sensitive and convenient protease-based fluorimetric high-throughput screening (HTS) assay for determining peptidyl-prolyl cis-trans isomerase activity was developed. The assay was based on a new intramolecularly quenched substrate, whose fluorescence and structural properties were examined together with kinetic constants and the ...
Caporale, Andrea +7 more
openaire +3 more sources
iScienceSummary: Peptidyl-prolyl cis/trans isomerases (PPIases) accelerate proline peptide bond isomerization, affecting substrate protein function. In this study, through RNAi-based behavioral screening of PPIases in Drosophila melanogaster, we identified ...
So Who Kang +5 more
doaj +1 more source
Commentary: Systems Biology Approach to Model the Life Cycle of Trypanosoma cruzi [PDF]
, 2017 In a recent work we have identified, from a bigger gene regulatory network, a seven-node moduleinvolved in the control of the life cycle of Trypanosoma cruzi (T. cruzi) (Carrea and Diambra,2016).
Alejandra Carrea, Luis Diambra
core +1 more source
mLife, EarlyView.Abstract Bacterial persisters show tolerance to bactericidal antibiotics and play essential roles in chronic infections; however, the general mechanisms underlying persister formation and antibiotic tolerance remain insufficiently characterized. In this study, the Escherichia coli Keio library was used to identify genes involved in ciprofloxacin ...
Zhenfang Mei +9 more
wiley +1 more source
Pin1 modulates the type 1 immune response. [PDF]
PLoS ONE, 2007 BACKGROUND/ABSTRACT: Immune responses initiated by T cell receptor (TCR) and costimulatory molecule mediated signaling culminate in maximal cytokine mRNA production and stability.
Stephane Esnault +7 more
doaj +1 more source
Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction
PROTEOMICS, EarlyView.ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella +6 more
wiley +1 more source
Yellow Lupine Cyclophilin Transcripts Are Highly Accumulated in the Nodule Meristem Zone
Molecular Plant-Microbe Interactions, 2001 Cyclophilin (CyP) is one of the enzymes that act as peptidylprolyl cis-trans isomerases (EC 5.2.1.8). The cDNA and an intronless gene coding for cytosolic CyP have been isolated from yellow lupine.
Katarzyna Nuc +2 more
doaj +1 more source
Desensitizing Mitochondrial Permeability Transition by ERK-Cyclophilin D Axis Contributes to the Neuroprotective Effect of Gallic Acid against Cerebral Ischemia/Reperfusion Injury [PDF]
, 2017 Ischemic stroke is a devastating disease with complex pathophysiology. Much evidence confirms that opening of the mitochondrial permeability transition pore (MPTP) is related with mitochondrial dysfunction to apoptosis in ischemic stroke, thus ...
Chen Chen +7 more
core +1 more source