Results 121 to 130 of about 3,828 (143)

Citrullinated Histone H3: Early Biomarker of Neutrophil Extracellular Traps in Septic Liver Damage

Journal of Surgical Research, 2019
Neutrophil extracellular traps (NETs) play a crucial role in host defense, but excess and prolonged interaction of NETs with platelets can cause severe inflammation and host organ damage. Modification of histone H3 by citrullination is involved in in vitro NET formation.
Kozo Nomura, Tomoharu Miyashita, Yasuhiko Yamamoto   +2 more
exaly   +3 more sources

Correlation of serum citrullinated histone H3 levels with disease activity in patients with rheumatoid arthritis

Clinical and Experimental Rheumatology, 2022
Serum citrullinated histone H3 (CitH3) levels in humans with rheumatoid arthritis (RA) were examined and the associations between CitH3 levels and disease variables were investigated.Serum CitH3 levels were measured using an enzyme-linked immunosorbent assay in 151 RA patients (69 with highly, 32 with moderately, and 20 with mildly active RA and 30 ...
Wanchan, Peng, Siyu, Wu, Wei, Wang
openaire   +2 more sources

Increased serum citrullinated histone H3 levels in COVID-19 patients with acute ischemic stroke

Ideggyógyászati szemle, 2022
Prevalence of acute ische­mic stroke (AIS) is increased in patients with coronavirus disease 2019 (COVID-19). A proposed hypothesis is increased virus-induced propensity to hypercoagulation resulting in arterial thrombosis. Our aim was to provide evidence regarding the involvement of neutrophil extracellular trap (NET) formation (NETosis) in COVID-19 ...
Muhammet Duran, Bayar, Aysel Büşra, Şişman, Gizem, Koral, Selen, Çirak, Erdem, Tüzün, Sefer, Günaydin, Birgül, Baştan   +6 more
openaire   +2 more sources

Citrullinated histone H3 is increased in blood of asthma subjects

Allergy and immunology, 2019
Histone H3 is citrullinated in the process of epigenetic chromatin remodelling and neutrophil extracellular trap (NET) formation. In 76 adult asthmatics and 54 well-matched controls we measured circulating level of citrullinated histone H3 (CitH3) using Cayman ELISA kit.
Pawel Kuczia, Joanna Żuk, Teresa Iwaniec, Jacek Zarychta, Jerzy Soja, Stanisława Bazan-Socha   +5 more
openaire   +1 more source

Identification of citrullinated histone H3 as a potential serum protein biomarker in a lethal model of lipopolysaccharide-induced shock [PDF]

Surgery, 2011
Circulating proteins may serve as biomarkers for the early diagnosis and treatment of shock. We have recently demonstrated that treatment with suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, significantly improves survival in a rodent model of lipopolysaccharide (LPS)-induced septic shock. Preliminary proteomic data showed that
Baoling Liu, Eugene Y Fukudome, Wei Chong   +2 more
exaly   +3 more sources

Elevated histone H3 citrullination is associated with increased Beclin1 expression in HBV‐related hepatocellular carcinoma

Journal of Medical Virology, 2020
AbstractCitrullinated histone H3 (H3Cit) is the product of the conversion of peptidylarginine to citrulline in histone H3. We evaluated the H3Cit level in hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC) tissues and assessed its association with Beclin1 messenger RNA (mRNA) (a key autophagic regulator).
Mingzhu Lu, Xianjing Zhang, Yun Xu, Guangzhao He, Qian Liu, Jing Zhu, Changsong Zhang   +6 more
openaire   +2 more sources

Sex-dependent mechanisms involved in renal tolerance to ischemia-reperfusion: Role of inflammation and histone H3 citrullination

Transplant Immunology, 2020
Ischemia-reperfusion (I/R) injury, an inevitable result of kidney transplantation, triggers early inflammatory events that affect graft viability. Evidence from human transplantation and preclinical models of I/R suggests that a female hormonal environment positively influences the ability to recover from ischemic injury. However, the mechanisms behind
Zesergio, Melo, Yanet Karina, Gutierrez-Mercado, David, Garcia-Martínez, Eliseo, Portilla-de-Buen, Alejandro A, Canales-Aguirre, Ricardo, Gonzalez-Gonzalez, Adriana, Franco-Acevedo, Julio, Palomino, Raquel, Echavarria   +8 more
openaire   +2 more sources

Impact of Neutrophil Extracellular Traps Identified by Citrullinated Histone H3 Immunohistochemistry for Postoperative Prognosis in Patients with Extrahepatic Cholangiocarcinomas

Annals of Surgical Oncology, 2023
Neutrophil extracellular traps (NETs) are extracellular chromatin structures composed of cytoplasmic, granular, and nuclear components of neutrophils. Recently, NETs have received much attention for their role in tumor biology; however, their impact on the postoperative prognosis of patients with extrahepatic cholangiocarcinomas (EHCCs) remains unclear.
Hiroyuki, Yamamoto, Yoshitsugu, Nakanishi, Tomoko, Mitsuhashi, Yutaka, Hatanaka, Kanako, Hatanaka, Ayae, Nange, Yusuke, Yoshida, Norito, Ino, Masaru, Go, Keisuke, Okamura, Takahiro, Tsuchikawa, Toru, Nakamura, Takehiro, Noji, Toshimichi, Asano, Aya, Matsui, Kimitaka, Tanaka, Soichi, Murakami, Yuma, Ebihara, Yo, Kurashima, Toshiaki, Shichinohe, Satoshi, Hirano   +20 more
openaire   +2 more sources

Citrullinated histone H3 expression in anti‐neutrophil cytoplasmic antibody‐associated vasculitis in older Japanese autopsy patients

Geriatrics and Gerontology International, 2019
AimNeutrophil extracellular traps play key roles in the necrotizing vasculitis associated with anti‐neutrophil cytoplasmic antibody‐associated vasculitis (AAV). However, the relationships between neutrophil extracellular traps formation and the distribution and phase of vasculitis are not well understood.
Yoko Matsuda, Tomoyasu Matsubara, Akira Shimizu   +2 more
exaly   +3 more sources

Presence of Citrullinated Histone H3‐Positive Neutrophils in Microscopic Polyangiitis from the Early Phase: An Autopsy Proven Case

Pathology International, 2016
AbstractA 76‐year‐old man was admitted with general fatigue, weight loss, fever, headache, renal failure, and a high serum level of myeloperoxidase‐antineutrophil cytoplasmic antibody. Biopsy revealed citrullinated histone H3 (citH3)‐positive neutrophils adherent to the temporal artery endothelium.
Yoko Matsuda, Yoshitomo Hamano, Toshio Kumasaka   +2 more
exaly   +3 more sources