Results 211 to 220 of about 14,198 (253)

Microbial Imbalance and Intestinal Permeability in the Pathogenesis of Rheumatoid Arthritis: A Mechanism Review with a Focus on Bacterial Translocation, Citrullination, and Probiotic Intervention.

Journal of the American Nutrition Association, 2023
This review aims to investigate the role of intestinal permeability (IP) in rheumatoid arthritis (RA), following the hypotheses that leakage of intestinal microbes can influence increased citrullination of peptides leading to anti-citrullinated protein ...
Holly C Blenkinsopp, K. Seidler, M. Barrow   +2 more
semanticscholar   +1 more source

5-HT orchestrates histone serotonylation and citrullination to drive neutrophil extracellular traps and liver metastasis

Journal of Clinical Investigation
Serotonin (5-HT) is a neurotransmitter that has been linked to tumorigenesis. Whether and how 5-HT modulates cells in the microenvironment to regulate tumor metastasis is largely unknown.
Kaiyuan Liu, Yingchao Zhang, Genyu Du, Xinyu Chen, Lingling Xiao, Luyao Jiang, Na Jing, Penghui Xu, Chaoxian Zhao, Yiyun Liu, Huifang Zhao, Yujiao Sun, Jinming Wang, Chaping Cheng, Deng Wang, Jiahua Pan, Wei Xue, Pengcheng Zhang, Zhi-gang Zhang, Wei‐Qiang Gao, Shuheng Jiang, Kaiqing Zhang, Helen He Zhu   +22 more
semanticscholar   +1 more source

Targeted citrullination enables p53 binding to non-canonical sites.

Molecules and Cells
TP53 encodes for the transcription factor p53, which binds to a diverse set of target genes in response to stress. Activation of p53 results in highly specific transcriptional responses, but the regulation of promoter selectivity by p53 is poorly ...
Alexandra Indeglia, Andrea Valdespino, Giulia Pantella, Sarah R. Offley, Connor Hill, Maya Foster, Kaitlyn Casey, Hsin-Yao Tang, Anneliese Faustino, Alessandro Gardini, Maureen E. Murphy   +10 more
semanticscholar   +1 more source

Citrulline metabolism in plants

Amino Acids, 2017
Citrulline was chemically isolated more than 100 years ago and is ubiquitous in animals, plants, bacteria, and fungi. Most of the research on plant citrulline metabolism and transport has been carried out in Arabidopsis thaliana and the Cucurbitaceae family, particularly in watermelon which accumulates this non-proteinogenic amino acid to very high ...
Vijay Joshi, Alisdair R. Fernie
openaire   +3 more sources

Citrulline utilization in Crithidia

Biochemical and Biophysical Research Communications, 1966
It was early noted in growth studies (Kidder and Dutta, 1958) that the trypanosomid flagellate Crithidia fasciculata could utilize citrulline, but not ornithine, as a replacement for arginine . A somewhat more efficient use of citrulline than arginine suggested that citrulline might be contributing directly to reactions other than just the production ...
G W, Kidder, J S, Davis, K, Cousens
openaire   +2 more sources

Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury

Advancement of science
Mediating protein citrullination, peptidyl arginine deiminase 2 (PAD2) has recently been reported to influence macrophage phenotypes. However, the mechanisms of PAD2 on macrophage function in Pseudomonas aeruginosa (PA)‐induced acute lung injury syndrome
Xin Yu, Yujing Song, Tao Dong, Wenlu Ouyang, Chao Quan, Liujiazi Shao, Leonard Barasa, Paul R. Thompson, Mao Zhang, Jianjie Ma, K. Kurabayashi, Yongqing Li   +11 more
semanticscholar   +1 more source

Citrulline and the gut

Current Opinion in Clinical Nutrition and Metabolic Care, 2007
Citrulline, a nonprotein amino acid, is an important source of endogenous arginine. The gut is the main source of citrulline in humans. Hence, citrulline is a potential biomarker of short bowel function. Conversely, citrulline uptake by the gut is important for an oral supply of this amino acid as an alternative to arginine. This review discusses these
Emmanuel, Curis, Pascal, Crenn, Luc, Cynober   +2 more
openaire   +2 more sources

Citrullination at the N‐terminal region of MDM2 by the PADI4 enzyme

Protein Science
PADI4 is one of the human isoforms of a family of enzymes involved in the conversion of arginine to citrulline. MDM2 is an E3 ubiquitin ligase that is critical for degradation of the tumor suppressor gene p53.
José L. Neira, B. Rizzuti, Martina Palomino-Schätzlein, Virginia Rejas, O. Abián, A. Velázquez‐Campoy   +5 more
semanticscholar   +1 more source

Citrullination negatively regulates the functions of the p53 protein and opposes its ubiquitination and degradation.

Proceedings of the National Academy of Sciences of the United States of America
This study investigates the regulatory role of peptidylarginine deiminase 4 (PAD4)-mediated citrullination on the tumor suppressor protein p53. We demonstrate that p53 serves as a substrate for PAD4, undergoing citrullination at multiple arginine ...
Yi-Fang Yang, Chien-Yun Lee, Guang-Yaw Liu, Ju-Yi Hsieh, Yi-Chun Lin, Li-Wei Wang, Kai-Han Chan, Won-Shin Yen, Yin-Chu Chen, Chi-Li Lin, Hui-Chih Hung   +10 more
semanticscholar   +1 more source

Biologically Active Citrulline Peptides

Nature, 1962
To the best of our knowledge no peptides have so far been synthesized with citrulline as a building component. This alone could be sufficient reason to study citrulline peptides, but our investigations were prompted by other considerations as well.
M, BODANSZKY, M A, ONDETTI, B, RUBIN, J J, PIALA, J, FRIED, J T, SHEEHAN, C A, BIRKHIMER   +6 more
openaire   +2 more sources