Results 221 to 230 of about 14,198 (253)

Development of a Chemoproteomic Platform to Identify Sites of (Homo)citrullination within Complex Proteomes.

ACS Chemical Biology
Citrullination and homocitrullination of arginine and lysine can significantly impact protein structure and function. Citrullination of arginine is an enzymatic modification catalyzed by Protein Arginine Deiminases (PADs). Homocitrullination of lysine is
Sarah A Mann, Leonard Barasa, Paul R. Thompson, E. Weerapana   +3 more
semanticscholar   +1 more source

Citrulline synthesis in rat tissues

Archives of Biochemistry and Biophysics, 1961
Abstract The distribution of carbamyl phosphate synthetase (CPS) and/or ornithine transcarbamylase (OTC) was determined in 17 different rat tissues. Both enzymes, but particularly OTC, were found to be located mainly in the liver so that assay for OTC activity can provide a highly specific test for liver parenchymal cells.
M E, JONES, A D, ANDERSON, C, ANDERSON, S, HODES   +3 more
openaire   +2 more sources

Citrullinated proteins in Rheumatoid Arthritis

Reumatología Clínica (English Edition), 2011
Rheumatoid arthritis is an autoimmune disease of multifactorial etiology characterized by inflammation of the joints and presence of autoantibodies directed against multiple autoantigens. Recently the study of the anti-citrullinated protein antibodies (ACP) has acquired great interest due to its high specificity and sensitivity for diagnosis, in ...
Elizabeth, Olivares Martínez, Diego F, Hernández Ramírez, Carlos A, Núñez-Álvarez, Javier, Cabiedes   +3 more
openaire   +2 more sources

Impact of Protein Citrullination by Periodontal Pathobionts on Oral and Systemic Health: A Systematic Review of Preclinical and Clinical Studies

Journal of Clinical Medicine
Background: This review synthesizes the role of Porphyromonas gingivalis (P. gingivalis) and Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) in modulating immune responses through citrullination and assesses its impact on periodontitis ...
Marco Bonilla, Natividad Martín-Morales, Rocío Gálvez-Rueda, Enrique Raya-Álvarez, Francisco Mesa   +4 more
semanticscholar   +1 more source

Citrullinated proteins in rheumatoid arthritis

Frontiers in Bioscience, 2005
Citrullinated proteins that are produced by enzymatic deimination of arginine residues in proteins by peptidylarginine deiminases (PADIs) are of particular interest in the pathogenesis of rheumatoid arthritis (RA). First, peptidylarginine deiminase type 4 (PADI4) gene, which codes one of the PADI enzyme isotypes, has a genetic variant that increases ...
Ryo, Yamada, Akari, Suzuki, Xiaotian, Chang, Kazuhiko, Yamamoto   +3 more
openaire   +2 more sources

Citrullination, a novel post-translational modification of elastin, is involved in COPD Pathogenesis.

American Journal of Physiology - Lung cellular and Molecular Physiology
Elastin is an extracellular matrix protein (ECM) that supports elasticity of the lung, and in patients with chronic obstructive pulmonary disease (COPD) and emphysema, the structural changes that reduce the amount of elastic recoil, lead to loss of ...
M. Murphy, Marina Zieger, Michael Henry, P. Meleady, Christian Mueller, N. Gerry McElvaney, E. Reeves   +6 more
semanticscholar   +1 more source

Citrulline and anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis

Future Rheumatology, 2006
Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by the destruction of multiple joints along with multiple organ involvement. The etiology of RA is still unknown. Various autoantigens have been proposed as targets of pathogenic T and B cells in RA, although none of their precise mechanisms or significance has been confirmed ...
Ryo Yamada, Akari Suzuki, Kazuhiko Yamamoto   +2 more
openaire   +1 more source

Metabolism of citrulline in man

Amino Acids, 1995
Citrulline is a non protein amino acid involved in three important metabolic pathways, the intrahepatic transformation of ammonia to urea, the de novo synthesis of arginine from glutamine in gut and kidney, the nitric oxide synthesis. The two first pathways use the same enzyme activities but are regulated in different way.
D, Rabier, P, Kamoun
openaire   +2 more sources

Citrulline production and protein homeostasis

Current Opinion in Clinical Nutrition & Metabolic Care, 2019
Protein homeostasis is crucial for maintaining cell functions. Citrulline, an endogenous amino acid, is considered as an efficient source of arginine at systemic and cellular level. Accumulating evidence, obtained from citrulline supplementation studies, suggest anabolic properties especially in malnourished rodents and human.
Antonin, Ginguay, Jean-Pascal, De Bandt
openaire   +2 more sources

Citrulline

2021
openaire   +1 more source