Results 141 to 150 of about 51,040 (246)

Nanomotor‐Driven Extracellular Vesicles With Effective Tissue Penetration for Targeted Therapy of Primary Ovarian Insufficiency

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Stem cells and their derived extracellular vesicles (EVs) offer hope for functional reconstruction and fertility in premature ovarian insufficiency (POI) caused by gonadotoxic drugs. However, the clinical application of EVs is impeded by their instability, limited tissue penetration, and lack of targeted delivery to ovarian injury sites. Here,
Yaoqin Mu, Jiachen Wu, Mingwei Lv, Xinyi Zhang, Yinhua Song, Jihui Ai, Ding Ma, Kezhen Li   +7 more
wiley   +1 more source

Antenatal and Neonatal Management of Siblings With Carbonic Anhydrase VA Deficiency

JIMD Reports, Volume 67, Issue 2, March 2026.
ABSTRACT Carbonic anhydrase VA (CAVA) deficiency (OMIM 114761) is an ultra‐rare inborn error of metabolism with fewer than 20 cases described. Affected infants present in the first days of life with hyperammonaemia, lactic acidosis, ketonaemia and encephalopathy.
Sophie Manoy, Tahlee Minto, Kalliope Demetriou, Matthew Lynch, Arthavan Selvanathan, Luke Jardine, Michelle Lipke, Carolyn Bursle, Anita Inwood, Jim McGill, David Coman   +10 more
wiley   +1 more source

Clinical, biochemical, and molecular profiles of three Sri Lankan neonates with pyruvate carboxylase deficiency

Advances in Laboratory Medicine
Pyruvate carboxylase, a mitochondrial enzyme, catalyses the conversion of glycolytic end-product pyruvate to tricarboxylic acid cycle intermediate, oxaloacetate. Rare pyruvate carboxylase deficiency manifests in three clinical and biochemical phenotypes:
Jasinge Eresha, Fernando Mihika, Indika Neluwa-Liyanage Ruwan, Ratnayake Pyara Dilani, Gamaathige Nalin, Ratnaranjith Ratnanathan, Schroeder Sabine, Jones Patricia, Volha Skrahina, Jayasena Subhashinie, Gunaratna Anusha Varuni, Bandara Ekanayake Asitha Niroshana, Rolfs Arndt   +12 more
doaj   +1 more source

Retinal Capillary Density Reduction Contributes to Dysthyroid Optic Neuropathy via an L‐Arginine‐NO Pathway: A Metabonomics and Clinical Trial Study

MedComm, Volume 7, Issue 3, March 2026.
Oxidative stress induces endothelial nitric oxide synthase (eNOS) uncoupling and L‐arginine depletion, reducing nitric oxide (NO) bioavailability in vascular endothelium and contributing to decreased retinal capillary density (RCD) in dysthyroid optic neuropathy (DON).
Yunhai Tu, Congcong Yan, Lu Chen, Weijie Liu, Xiaozhou Hu, Mengyuan Gao, Wei Rao, Jiayi Zhang, Junye Zhu, Hui Wu, Kang Zhang, Meng Zhou, Wencan Wu   +12 more
wiley   +1 more source

Plasma Citrulline in the Diagnosis and Follow-Up of Celiac Disease

Children
Background/Objectives: Citrulline, an amino acid produced by small bowel enterocytes, has been proposed as a potential marker of intestinal absorptive capacity.
Alicia Isabel Pascual Pérez, Elene Larrea Tamayo, Santiago Jiménez Treviño, David González Jiménez, David Pérez Solís, Cristina Molinos Norniella, Juan José Díaz Martín   +6 more
doaj   +1 more source

Trans‐Omics Integration Reveals That the Kidney Contributes to Systemic Aging via Sexually Dimorphic Accumulation of Glycosphingolipids

MedComm, Volume 7, Issue 3, March 2026.
Female‐specific renal GluCer accumulation disrupts mitochondrial quality control via a conserved purine‐mTORC1 pathway, triggering a wave of uremic toxins into the systemic circulation that constitutes a female‐biased vulnerability toward renal‐driven multiorgan senescence.
Zhen Ni, Chenyin Cao, Yanlin Tian, Jinming Mu, He Tian, Zehua Wang, Shaohua Zhang, Mingjun Cao, Yuntian Yang, Wei Ling Florence Lim, Jingkang Cui, Huan Sun, Huan Miao, Yuan Wang, Jie Du, Timothy Kwok, Huan Chen, Sin Man Lam, Guanghou Shui   +18 more
wiley   +1 more source

Mechanisms of L-citrulline on phosphodiesterase 5 in erectile dysfunction intervention

Scientific African
Erectile dysfunction (ED) is a prevalent condition linked to diabetes and cardiovascular diseases, with conventional treatments often associated with adverse effects. Plant-derived products, though less explored, offer potential alternatives.
Abdulhakeem Olarewaju Sulyman, Olawale Moshood Aliyu, Emmanuel Oladipo Ajani, Yusuf Folohunsho Abdulkareem, Isaac Ade Afe, Fathia Oluwakemi Abdulyakeen, Halimat Yusuf Lukman, Saheed Sabiu, Karishma Singh, Kuben Naidoo   +9 more
doaj   +1 more source

Citrulline [PDF]

, 2020
openaire   +1 more source

Urine Metabolism Biomarkers Predict Preterm Infant Adiposity at Hospital Discharge

Molecular Nutrition &Food Research, Volume 70, Issue 6, 29 March 2026.
In this cohort of term and preterm infants, urinary amino acid and acylcarnitine concentrations varied by diabetes in pregnancy exposure and gestational age at birth, and certain patterns of urinary metabolites were differentially related to postnatal adiposity development in preterm infants of women with diabetes in pregnancy. ABSTRACT In infants born
Catherine O. Buck, Sarah McCollum, Weiwei Wang, TuKiet T. Lam, Sarah N. Taylor, Veronika Shabanova   +5 more
wiley   +1 more source

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source