Results 151 to 160 of about 37,088 (271)

Discovery of Post‐Translationally Modified Epitopes in Autoimmunity: Someone Has to Fish so Everyone Can Eat

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT Post‐translational modifications (PTMs) chemically diversify the ~20,000 genomically encoded proteins into millions of functional variants, and this diversity has profound consequences for T cell‐mediated immune responses. PTM‐reactive T cells have been identified across numerous autoimmune diseases and, in several cases, implicated directly ...
Sanya Arshad, Benjamin M. Cameron, Alok V. Joglekar   +2 more
wiley   +1 more source

Plasma Citrulline as a Biomarker in Critical Illness: A Structured Narrative Review. [PDF]

Diagnostics (Basel)
Frandeș O, Lazăr AE, Frandeș SI, Branea OE, Azamfirei L.   +4 more
europepmc   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

Feeding Intolerance and Citrulline Generation Test in the Critically Ill: A Prospective Study. [PDF]

Nutrients
Hild C, Vieille T, Puyraveau M, Winiszewski H, Riedweg KM, Piton G.   +5 more
europepmc   +1 more source

Cytotoxic Effects of Medicinal Plant Extracts on HeLa Cells via Redox Imbalance, L‐Arginine Metabolic Reprogramming, and Glycolytic Suppression

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Cancer cells undergo metabolic reprogramming to sustain proliferation, resist apoptosis, and adapt to oxidative stress. In the present study, we comparatively evaluated the anticancer effects of four medicinal plant extracts (Inula helenium, Hypericum alpestre, Rumex obtusifolius, and Alchemilla smirnovii) on HeLa cervical cancer cells, with ...
Mery Kocharyan, Gohar Sevoyan, Hasmik Karapetyan, Anzhela Sargsyan, Mikayel Ginovyan, Nikolay Avtandilyan, Hayarpi Javrushyan   +6 more
wiley   +1 more source

Lactiplantibacillus plantarum AS21 Attenuates Sex-Biased Glucose Intolerance in Aging Mice via Gut Mucosal Microbiota-Derived Citrulline. [PDF]

Aging Cell
Jia M, Chen M, Chen H, Zhang H, Dou R, Wang C, Ishaq M, Wei X, Ding Z, Guo X.   +9 more
europepmc   +1 more source

Pyrroloquinoline Quinone Attenuates Traumatic Brain Injury‐Induced Secondary Damage by Activating PINK1/Parkin‐Mediated Mitophagy and Suppressing ASS1/CPS1‐Driven Arginine Biosynthesis

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Pyrroloquinoline quinone (PQQ) attenuates traumatic brain injury in mice. Multi‐omics integration and molecular docking reveal that PQQ activates PINK1/Parkin‐mediated mitophagy to restore mitochondrial homeostasis while suppressing ASS1/CPS1‐driven arginine biosynthesis to dampen neuroinflammation, identifying a dual‐axis therapeutic mechanism for TBI.
Yanan He, Lu Yu, Yixun Lu, Zhikang Zhou, Ao Li, Lu Wang, Zhili Huang, Yanhong Liu, Yulong Ma, Weidong Mi   +9 more
wiley   +1 more source

NF-κB citrullination [PDF]

Nature Immunology, 2017
openaire   +2 more sources

Beyond natural amino acids: extending immunogenicity risk assessment to modified peptides through chemical feature encoding. A case study on citrullination. [PDF]

Front Immunol
Cairoli M, Nielsen M, Betts C, Obrezanova O, De Maria L.   +4 more
europepmc   +1 more source

Arginase 2 deficiency mitigates sepsis‐associated acute kidney injury by alleviating lipid accumulation

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
1. Spatiotemporal multi‐omics atlas reveals regional metabolic and proteomic specificity during sepsis‐to‐S‐AKI progression. 2. Arginine metabolism is central to S‐AKI pathogenesis, with declining arginine levels correlating with worsening renal function. 3. ARG2 upregulation in renal tubules and macrophages drives tubular lipid accumulation and kidney
Yu Xin, Yanqi Liu, Ning Zhang, Pengfei Huang, Qianqian Zhang, Yinghao Luo, Xinran Wang, Xiuhua Zhang, Tao Wu, Fengye Liu, Yu Xiao, Lifeng Shen, Weiting Zhang, Xibo Wang, Xianglin Meng, Yuping Bai, Xuan Wang, Nan Zhang, Qianghong Xu, Hongxue Meng, Xubin Zheng, Lixin Cheng, Kaijiang Yu, Changsong Wang   +23 more
wiley   +1 more source