Results 91 to 100 of about 40,048 (221)

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Characteristics of Helicobacter pylori antibiotic resistance: data from four different populations

Antimicrobial Resistance and Infection Control, 2019
Aims To describe the characteristics of Helicobacter pylori (H. pylori) antibiotic resistance in clinical isolates from four populations. Methods In total, 1463 H. pylori strains were examined for antibiotic resistance.
Dong-sheng Liu, You-hua Wang, Zhen-hua Zhu, Shuang-hong Zhang, Xuan Zhu, Jian-hua Wan, Nong-hua Lu, Yong Xie   +7 more
doaj   +1 more source

A descriptive case series of hepatotoxicity associated with CFTR modulators and possible relevance of pharmacogenetic polymorphisms in cystic fibrosis patients

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3257-3264, September 2026.
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are widely used in patients with cystic fibrosis and significantly improve respiratory function and quality of life. However, their effectiveness may be limited by liver damage, which sometimes leads to treatment discontinuation, and the mechanisms underlying this remain poorly ...
Clara Laffitte Redondo, Venceslas Bourdin, Abd El Kader Ait Tayeb, Sihem Benaboud, Inès Martins, Caroline Joyau, Myriam Benhamida, Isabelle Sermet‐Gaudelus, Clémence Martin, Pierre Régis Burgel, Céline Verstuyft, Laurent Chouchana, Estelle Ayme‐Dietrich   +12 more
wiley   +1 more source

Primary Clarithromycin Resistance in Helicobacter pylori: the Multicentric Italian Clarithromycin Resistance Observational (MICRO) Study

, 2011
BACKGROUND: Primary clarithromycin resistance markedly reduces Helicobacter pylori eradication rate following standard therapies. Prevalence of primary clarithromycin resistance in H.
Marone A, Pedroni A, Peri V, Mirante VG, Manes G, Ierardi E, Luzza F, USAI, PAOLO, de Matthaeis M, Zotti M, Pallotta S, Manta R, Hassan C, De Francesco V, Varasano V, Liggi M, Bresci G, Sacco R, Giorgio F, Neri M, Gatto G, Zullo A., Milano A, Marmo R, Suraci E, Monica F   +25 more
core  

Two approaches to the use of benzo[c][1,2]oxaboroles as active fragments for synthetic transformation of clarithromycin

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Clarithromycin (active against Gram positive infections) and 1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole derivatives (effective for Gram negative microbes) are the ligands of bacterial RNA. The antimicrobial activities of these benzoxaboroles linked with
Gennady B. Lapa, Elena P. Mirchink, Elena B Isakova, Maria N Preobrazhenskaya   +3 more
doaj   +1 more source

Target‐Specific Dermatological Adverse Event Reporting With T‐Cell–Engaging Bispecific Antibodies: A Pharmacovigilance Analysis of FAERS and Canada Vigilance, 2016–2026

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Background T‐cell–engaging bispecific antibodies are increasingly utilised in haematological malignancies and are beginning to be adopted in solid‐tumour treatment protocols. Cytokine release syndrome and neurotoxicity are well recognised, but target‐specific dermatological adverse event reporting patterns remain poorly defined.
Saikat Mandal, Manideepa Maji, Arkadeep Dhali   +2 more
wiley   +1 more source

High Helicobacter pylori resistance rate to clarithromycin in Turkey

, 2007
Goals: To assess the resistance of Helicobacter pylori to clarithromycin in Turkey. Background: Recent studies have emphasized the remarkable reduction in H. pylori eradication rates.
Ozutemiz, Omer, Akarca, Ulus, Ilter, Tankut, Onder, Goktug, Aydin, Ahmet, Tekin, Fatih   +5 more
core   +1 more source

Current Helicobacter pylori Diagnostics: Established Methods, Resistance Testing, and Emerging Approaches

JGH Open, Volume 10, Issue 9, September 2026.
ABSTRACT Aims Accurate diagnosis of Helicobacter pylori infection is required to detect active infection, confirm eradication, assess gastric pathology when indicated, and obtain antimicrobial resistance information that may guide treatment. This review evaluates the clinical roles, limitations, and implementation maturity of established, molecular ...
Tianhua Tang, Erwin A. Paz, Kan Yu, Khui Hung Lee, Chin Yen Tay, Jingjing Wang, Barry James Marshall, Linli Hu, Wanting Fu, Ziyao Yang   +9 more
wiley   +1 more source

Torsades de pointes following clarithromycin treatment

, 2013
A 75-year-old woman presenting with pre-syncope, shortness of breath and nausea was admitted to the emergency department following treatment with clarithromycin. Shortly after admission she developed a prolonged QT interval leading to torsades de pointes
Vieweg, W Victor R, Hasnain, Mehrul, Hancox, Jules C, Gysel, Michael, Baranchuk, Adrian, Kunanithy, Vitharani   +5 more
core   +1 more source

Net Renal Drug Secretion Critically Requires Significant Contribution of Basal Uptake Transporters: Perspective From Mechanistic Kidney Model Simulation and Integration of Clinical and In Vitro Data

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Renal clearance (CLr) is the net outcome of glomerular filtration, secretion, and reabsorption, which makes the quantitative requirements for net renal secretion difficult to infer from simple clearance models. Using a mechanistic kidney model (MechKiM), we simulated blood‐referenced CLr (CLr,b) for 30,000 virtual drugs (neutral, monoanionic ...
Toshiaki Tsuchitani, Masatoshi Tomi, Yuichi Sugiyama   +2 more
wiley   +1 more source