Results 81 to 90 of about 57,560 (274)

Impact of CYP2C19 and CYP3A4 Inhibitor Use on Clopidogrel Clinical Effectiveness in CYP2C19 Genotyped Patients Undergoing Percutaneous Coronary Intervention

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2C19 and CYP3A4 contribute to clopidogrel bioactivation. CYP2C19 no‐function alleles diminish clopidogrel's antiplatelet effects and clinical effectiveness. Coadministration of either a CYP2C19 or a CYP3A4 inhibitor may also reduce clopidogrel's antiplatelet effects and lead to phenoconversion in patients without a CYP2C19 no‐function allele (normal/
Danwei Shao, Jean G. Malavé, Joseph S. Rossi, Francesco Franchi, Ellen C. Keeley, Dominick J. Angiolillo, George A. Stouffer, Larisa H. Cavallari, Craig R. Lee   +8 more
wiley   +1 more source

Genotypic and Phenotypic Resistance to Clarithromycin in Helicobacter pylori Strains

, 2020
Background: The increasing prevalence of antimicrobial resistance, together with the lack of novel treatment options, negatively affects successful eradication of Helicobacter pylori.
Ji Yong Ahn, Jeong Hoon Lee, So Won Kim, Sun Mi Lee, Ho June Song, Kee Wook Jung, Eun Jeong Gong, Jung Mogg Kim, Hwoon-Yong Jung, Gin Hyug Lee, Kee Don Choi, Hee Kyong Na, Do Hoon Kim   +12 more
core   +1 more source

Clinical Images: A thorn injury, a sea‐borne culprit, and a tenosynovitis dilemma

Arthritis &Rheumatology, EarlyView.
Jacopo Ciaffi, Francesco Mori, Paolo Sassu, Marco Gambarotti, Alberto Righi, Eleonora Zamparini, Marco Innocenti, Marina Tadolini, Francesco Ursini   +8 more
wiley   +1 more source

Maternal infection in the context of actively managed prelabor rupture of membranes at term: An observational study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To assess maternal infection following prelabor rupture of membranes (PROM) at term in a setting where active management is recommended, and to identify associated risk factors. Methods A retrospective cohort study was conducted including pregnant women admitted to a Portuguese tertiary care center where immediate induction of labor ...
Inês Martins, Inês Gomes Brou, Miguel Macedo, Luísa Pinto   +3 more
wiley   +1 more source

Quantification of clarithromycin polymorphs in presence of tablet excipients [PDF]

, 2016
Excipients can cause a considerable challenge when developing a solid form of an active pharmaceutical ingredient (API). The aim of this present study was to analyze the polymorphs of clarithromycin (CAM) mixed with excipients using powder X-ray ...
Ganesh Shete, Arvind Kumar Bansal, Swathi Kuncham   +2 more
core  

Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy

, 2006
Aim: To determine the antibiotic susceptibility of Helicobacter pylori and evaluate the efficacy of a clarithromycin-based triple therapy in relation to antibiotic resistance.
Chan, C. K., Xia, HHX, Wong, BCY, Wang, JD, Chan, AOO, Xia, H. H. X., Lam, Sx., Wang, J. D., Yuen, MF, Chan, A. O. O., Lam, SK, Gu, Q, Chan, CK, Gu, Q., Fung, F. M. Y., Wong, WM, Wong, B. C. Y., Fung, FMY, Lai, K. C., Wong, K. W., Lai, KC, Wong, W. M., Yuen, M. F., Wong, KW   +23 more
core   +1 more source

Long-Term Risk of Acute Myocardial Infarction, Stroke, and Death With Outpatient Use of Clarithromycin: A Retrospective Cohort Study

American Journal of Epidemiology, 2018
In a retrospective cohort study of patients enrolled in the UK Clinical Practice Research Datalink during 2000-2013, we evaluated long-term risks of death, stroke, and acute myocardial infarction (AMI) in adults prescribed clarithromycin.
A. Mosholder, Joo-Yeon Lee, Esther H Zhou, Elizabeth M. Kang, Mayurika Ghosh, R. Izem, J. Major, D. Graham   +7 more
semanticscholar   +1 more source

On‐site pilot‐scale advanced oxidation pretreatment of hospital wastewater: assessment of pharmaceuticals, pathogens, antibiotic resistance genes and acute ecotoxicity

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Hospital premises generate wastewater containing a wide spectrum of contaminants, such as pharmaceutically active compounds (PhACs), antibiotic resistance genes (ARGs) and pathogenic microorganisms, whilst plenty of them are classified under the antibiotic resistant bacteria (ΑRΒ) category.
Andreas Kaliakatsos, Iosifina Gounaki, Spyros Dokianakis, Georgios Gkotsis, Maria‐Christina Nika, Eleni Aleiferi, Athanasios S Stasinakis, Nikos Katsarakis, Nikolaos S Thomaidis, Thrassyvoulos Manios, Michalis S Fountoulakis, Danae Venieri   +11 more
wiley   +1 more source

The Clarithromycin Susceptibility Genotype Affects the Treatment Outcome of Patients with Mycobacterium abscessus Lung Disease

Antimicrobial Agents and Chemotherapy, 2018
Mycobacterium abscessus accounts for a large proportion of lung disease cases caused by rapidly growing mycobacteria. The association between clarithromycin sensitivity and treatment outcome is clear. However, M.
Qi Guo, Haiqing Chu, M. Ye, Zhemin Zhang, Bing Li, Shiyi Yang, Wei Ma, F. Yu   +7 more
semanticscholar   +1 more source

Clarithromycin attenuates mastectomy-induced acute inflammatory response

, 2000
Based on the observation that administration of clarithromycin led to an attenuation of the inflammatory response induced by surgical trauma in a guinea pig model, we investigated the potential beneficial effects of clarithromycin on the local and ...
Wei, WI, Chow, LWC, Woo, PCY, Yuen, KY
core   +1 more source