Results 1 to 10 of about 88,400 (300)

A Synthetic Analogue of Neopeltolide, 8,9-Dehydroneopeltolide, Is a Potent Anti-Austerity Agent against Starved Tumor Cells

Marine Drugs, 2017
Neopeltolide, an antiproliferative marine macrolide, is known to specifically inhibit complex III of the mitochondrial electron transport chain (mETC). However, details of the biological mode-of-action(s) remain largely unknown.
Haruhiko Fuwa, Mizuho Sato
doaj   +1 more source

Global prevalence of macrolide-resistant Staphylococcus spp.: a comprehensive systematic review and meta-analysis

Frontiers in Microbiology
BackgroundStaphylococcus is a genus of bacteria responsible for various infections ranging from mild skin to severe systemic diseases. Methicillin-resistant Staphylococcus aureus (MRSA) and coagulase-negative staphylococci (CoNS) are significant ...
Tahereh Navidifar, Abbas Zare Banadkouki, Abbas Zare Banadkouki, Elnaz Parvizi, Maryam Mofid, Narges Golab, Masoumeh Beig, Mohammad Sholeh   +7 more
doaj   +1 more source

Assessment of Prescribing and Monitoring Habits for Patients Taking an Antiarrhythmic and Concomitant QTc-Prolonging Antibiotic

Pharmacy, 2017
Patients may intermittently require antimicrobial therapy with a QTc-prolonging antibiotic, which presents a challenge for prescribers of patients already taking a QTc-prolonging antiarrhythmic.
Kelsey Noss, Sandra M. Aguero, Travis Reinaker   +2 more
doaj   +1 more source

Comparing the Antimicrobial In Vitro Efficacy of Amoxicillin/Metronidazole against Azithromycin—A Systematic Review

Dentistry Journal, 2018
On account of its proven clinical efficacy, the combination of systemically administered amoxicillin and metronidazole is frequently adjuncted to non-operative periodontal therapy and well documented.
Manuela Kaufmann, Patrik Lenherr, Clemens Walter, Thomas Thurnheer, Thomas Attin, Daniel B. Wiedemeier, Patrick R. Schmidlin   +6 more
doaj   +1 more source

Resistance to 16-Membered Macrolides, Tiamulin and Lincomycin in a Swine Isolate of Acholeplasma laidlawii

Antibiotics, 2021
Acholeplasma (A.) laidlawii is an opportunistic pathogen with the ability to disseminate resistance determinants to antibiotics; however, its resistance to macrolides has been less studied.
María M. Tavío, Ana S. Ramírez, Carlos Poveda, Rubén S. Rosales, Cristina F. Malla, José B. Poveda   +5 more
doaj   +1 more source

A carbohydrate approach for the formal total synthesis of (−)-aspergillide C

Beilstein Journal of Organic Chemistry, 2014
An enantioselective formal total synthesis of aspergillide C is accomplished using commercially available tri-O-acetyl-D-galactal employing a Ferrier-type C-glycosylation, utilizing a Trost hydrosilylation and protodesilylation as key reactions.
Pabbaraja Srihari, Namballa Hari Krishna, Ydhyam Sridhar, Ahmed Kamal   +3 more
doaj   +1 more source

Distribution of ermB, ermF, tet(W), and tet(M) Resistance Genes in the Vaginal Ecosystem of Women during Pregnancy and Puerperium

Pathogens, 2021
The inhabitants of the vaginal ecosystem can harbor genetic determinants conferring antimicrobial resistance. However, detailed data about the distribution of resistance genes in the vaginal microbiome of pregnant women are still lacking.
Marco Severgnini, Tania Camboni, Camilla Ceccarani, Sara Morselli, Alessia Cantiani, Sara Zagonari, Giulia Patuelli, Maria Federica Pedna, Vittorio Sambri, Claudio Foschi, Clarissa Consolandi, Antonella Marangoni   +11 more
doaj   +1 more source

Clindamycin Resistance Detection among MRSA at a Tertiary Care Hospital: A Cross-sectional Study [PDF]

National Journal of Laboratory Medicine
Introduction: Antimicrobial resistance is on the rise, posing a global threat to the success of modern surgical procedures. A common and notorious superbug causing community and hospital-acquired infections is Methicillin-resistant Staphylococcus aureus (
V Aruna, VM Theeba, S Arul Selvan, Rajesh Sengodan   +3 more
doaj   +1 more source

Macrolide myths [PDF]

Current Opinion in Microbiology, 2008
In spite of decades of research, our knowledge of the mode of interaction of macrolide antibiotics with their ribosomal target and of the mechanism of action of these drugs remain fragmentary. Experimental facts obtained over the past several years question some of the concepts that were viewed as a 'common knowledge'.
openaire   +2 more sources

Macrolide and macrolide-related antibacterial agents

Folia Pharmacologica Japonica, 2007
マクロライド系抗菌薬は，グラム陽性菌および非定型病原体に対する抗菌力が強く，呼吸器疾患の治療薬として汎用されてきた．我が国では，14員環，15員環および16員環マクロライド系およびケトライド系抗菌薬が上市している．エリスロマイシンの欠点を克服するための創薬研究から，ニューマクロライドと呼ばれるマクロライド系抗菌薬のロキシスロマイシン，クラリスロマイシンおよびアジスロマイシンが半合成された．その後，耐性肺炎球菌に対する抗菌活性が増強された，ケトライド系抗菌薬のテリスロマイシンが半合成された．本稿では主として，14，15員環マクロライド系およびケトライド系を中心とした抗菌薬の創薬・開発研究の歴史ならびに抗菌作用の特徴を概説した．
openaire   +3 more sources