Structure-activity relationship studies on the macrolide exotoxin mycolactone of Mycobacterium ulcerans [PDF]
, 2013 BACKGROUND: Mycolactones are a family of polyketide-derived macrolide exotoxins produced by Mycobacterium ulcerans, the causative agent of the chronic necrotizing skin disease Buruli ulcer.
Gerd Pluschke +34 more
core +2 more sources
Marine Drugs, 2013 Agents capable of inducing phase II enzymes such as quinone reductase 1 (QR1) are known to have the potential of mediating cancer chemopreventive activity.
Brian T. Murphy +5 more
doaj +1 more source
Antibiotic use in childhood alters the gut microbiota and predisposes to overweight
Microbial Cell, 2016 A correlation between the use of antibiotics in early life and the excessive weight gain in later childhood has been shown in several large cohort studies all over the world.
Katri Korpela, Willem M de Vos
doaj +1 more source
Macrolide Resistance of Mycoplasma pneumoniae, South Korea, 2000–2011
Emerging Infectious Diseases, 2013 In Korea, Mycoplasma pneumoniae was detected in 255/2,089 respiratory specimens collected during 2000–2011; 80 isolates carried 23S rRNA gene mutations, and 69/123 culture-positive samples with the mutation were resistant to 5 macrolides.
Ki Bae Hong +10 more
doaj +1 more source
P1 gene of Mycoplasma pneumoniae isolated from 2016 to 2019 and relationship between genotyping and macrolide resistance in Hokkaido, Japan [PDF]
, 2021 We characterized 515 Mycoplasma pneumoniae specimens in Hokkaido. In 2013 and 2014, the p1 gene type 1 strain, mostly macrolide-resistant, was dominant and the prevalence of macrolide resistance was over 50 %.
Tabata, Yuichi +45 more
core +1 more source
New Macrolide-Lincosamide-Streptogramin B Resistance Gene erm(48) on the Novel Plasmid pJW2311 in Staphylococcus xylosus. [PDF]
, 2017 Whole-genome sequencing of Staphylococcus xylosus strain JW2311 from bovine mastitis milk identified the novel 49.3-kb macrolide-lincosamide-streptogramin B (MLSB) resistance plasmid pJW2311.
Wipf, Juliette Ramona Karin +25 more
core +1 more source
Beilstein Journal of Organic Chemistry, 2014 Natural product-like macrocycles were designed as potential antibacterial compounds. The macrocycles featured a D-glucose unit fused into a 12- or 13-member macrolactone.
Richard T. Desmond +5 more
doaj +1 more source
Could Azithromycin Be Part of Pseudomonas aeruginosa Acute Pneumonia Treatment?
Frontiers in Microbiology, 2021 Azithromycin (AZM) is a 15-membered-ring macrolide that presents a broad-spectrum antimicrobial activity against Gram-positive bacteria and atypical microorganisms but suffers from a poor diffusion across the outer-membrane of Gram-negative bacilli ...
Anne-Gaëlle Leroy +13 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 Omadacycline is a novel tetracycline antibiotic that exhibits good in vitro antibacterial activity against atypical pathogens such as Mycoplasma pneumoniae. It is approved for the treatment of adults with community-acquired bacterial pneumonia.
Limin Xu, Changquan Fang
doaj +1 more source
Molecular Basis of Macrolide, Triamilide, and Lincosamide Resistance in Pasteurella multocida from Bovine Respiratory Disease [PDF]
, 2011 The mechanism of macrolide-triamilide resistance in Pasteurella multocida has been unknown. During whole-genome sequencing of a multiresistant bovine P.
Sweeney, M.T. +21 more
core +1 more source