Results 21 to 30 of about 86,656 (282)
Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont
Angewandte Chemie, EarlyView.Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley +11 more
wiley +2 more sources
Pharmacokinetics of Azalomycin F, a Natural Macrolide Produced by Streptomycete Strains, in Rats
Molecules, 2021 As antimicrobial resistance has been increasing, new antimicrobial agents are desperately needed. Azalomycin F, a natural polyhydroxy macrolide, presents remarkable antimicrobial activities. To investigate its pharmacokinetic characteristics in rats, the
Su He +7 more
doaj +1 more source
, 2022 Background: Expansion of the single sequence type 3 (ST3) was associated with a high macrolide resistance rate among Mycoplasma pneumoniae in Korea during the 2014–2016 epidemic. This study investigates the macrolide resistance rate and genetic diversity
Jae Hong Choi +9 more
core +1 more source
The Effect of Antibiotics on the Infant Gut Fungal Microbiota
Journal of Fungi, 2022 Antibiotics are commonly used drugs in infants, causing disruptions in the developing gut microbiota with possible detrimental long-term effects such as chronic inflammatory diseases.
Rebecka Ventin-Holmberg +7 more
doaj +1 more source
Exacerbation Prevention and Management of Bronchiectasis [PDF]
Tuberculosis and Respiratory Diseases, 2023 Bronchiectasis, which is characterized by irreversibly damaged and dilated bronchi, causes significant symptoms, poor quality of life, and increased economic burden and mortality rates.
Joon Young Choi
doaj +1 more source
Toxins, 2023 Phytotoxic macrolides attract attention as prototypes of new herbicides. However, their mechanisms of action (MOA) on plants have not yet been elucidated. This study addresses the effects of two ten-membered lactones, stagonolide A (STA) and herbarumin I
Elena V. Tyutereva +8 more
doaj +1 more source
Occurrence and Removal of Macrolides in Municipal Wastewater Treatment Plants: A Review
Journal of Environmental Health and Sustainable Development, 2021 Introduction: Macrolides are a group of antibacterial agents. Given their clinical importance, and the consistent rise in resistance among pathogenic bacteria, macrolides have been the targets of extensive research.
Zahra Abbasi, Mehdi Ahmadi
doaj
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Marine Drugs, 2017 Neopeltolide, an antiproliferative marine macrolide, is known to specifically inhibit complex III of the mitochondrial electron transport chain (mETC). However, details of the biological mode-of-action(s) remain largely unknown.
Haruhiko Fuwa, Mizuho Sato
doaj +1 more source
Frontiers in MicrobiologyBackgroundStaphylococcus is a genus of bacteria responsible for various infections ranging from mild skin to severe systemic diseases. Methicillin-resistant Staphylococcus aureus (MRSA) and coagulase-negative staphylococci (CoNS) are significant ...
Tahereh Navidifar +7 more
doaj +1 more source