Results 41 to 50 of about 86,656 (282)
Poly(I:C)‐Activated Nasal Fibroblasts Promote Eosinophil Recruitment in CRSwNP
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent mucosal inflammation and eosinophilic infiltration. Although epithelial and immune cells have been widely studied, the role of nasal fibroblasts in innate immune activation and eosinophil recruitment remains unclear.
Chaewon Shin +5 more
wiley +1 more source
Macrolide and macrolide-related antibacterial agents
Folia Pharmacologica Japonica, 2007 マクロライド系抗菌薬は，グラム陽性菌および非定型病原体に対する抗菌力が強く，呼吸器疾患の治療薬として汎用されてきた．我が国では，14員環，15員環および16員環マクロライド系およびケトライド系抗菌薬が上市している．エリスロマイシンの欠点を克服するための創薬研究から，ニューマクロライドと呼ばれるマクロライド系抗菌薬のロキシスロマイシン，クラリスロマイシンおよびアジスロマイシンが半合成された．その後，耐性肺炎球菌に対する抗菌活性が増強された，ケトライド系抗菌薬のテリスロマイシンが半合成された．本稿では主として，14，15員環マクロライド系およびケトライド系を中心とした抗菌薬の創薬・開発研究の歴史ならびに抗菌作用の特徴を概説した．
openaire +3 more sources
Current Opinion in Microbiology, 2008 In spite of decades of research, our knowledge of the mode of interaction of macrolide antibiotics with their ribosomal target and of the mechanism of action of these drugs remain fragmentary. Experimental facts obtained over the past several years question some of the concepts that were viewed as a 'common knowledge'.
openaire +2 more sources
High levels of macrolide-resistant Mycoplasma genitalium in Queensland, Australia
, 2017 The macrolide azithromycin is recommended for treatment of Mycoplasma genitalium infection; however, M. genitalium strains possessing macrolide resistance-mediating mutations (MRMMs) are increasingly being reported.
Bletchly, Cheryl +11 more
core +1 more source
Targeting potassium channels and autophagy to defeat chemoresistance
Molecular & Cellular Oncology, 2020 Both autophagy and hERG1 potassium channels have been shown to promote tumor progression and resistance to treatment. Our findings indicate that the antibiotic clarithromycin can target hERG1 and modulate autophagy to promote the death of chemoresistant ...
Giulia Petroni
doaj +1 more source
Clinical and molecular analysis of macrolide resistance in Mycobacterium avium complex lung disease
, 2006 Supported by institutional funding at the University of Texas Health Science Center at Tyber (UTHCT).Rationale: The clinical features and outcome of macrolide-resistant Mycobacterium avium complex (MAC) lung disease are not known.
Caccitolo, James +12 more
core +1 more source
Understanding the spread of de novo and transmitted macrolide-resistance in Mycoplasma genitalium. [PDF]
, 2020 Background The rapid spread of azithromycin resistance in sexually transmitted Mycoplasma genitalium infections is a growing concern. It is not yet clear to what degree macrolide resistance in M.
Jensen, Jørgen S +10 more
core +3 more sources
Asia-Pacific Journal of Chemical Engineering, EarlyView.ABSTRACT The presence of antibiotics in water not only causes environmental pollution but also increases the growth of antibiotic‐resistant bacterial genes, which pose serious threats to human beings and other water residents. Large numbers of people are reportedly affected by the resistant bacterial genes, as many broad‐spectrum antibiotics are not ...
Amir Zada, Shohreh Azizi
wiley +1 more source
Role of ethambutol and rifampicin in the treatment of Mycobacterium avium complex pulmonary disease
BMC Pulmonary Medicine, 2019 Background A three-drug regimen (macrolide, ethambutol, and rifampicin) is recommended for the treatment of Mycobacterium avium complex pulmonary disease (MAC-PD).
Hyung-Jun Kim +6 more
doaj +1 more source
Bacteriological and Molecular Identification of some Campylobacter Species in Broilers and their Macrolide Resistance Profile [PDF]
Benha Veterinary Medical Journal, 2018 Genus campylobacter including several species is of great importance that is considered among the major causative agents of acute diarrheal diseases in humans worldwide.
Ahmed Hefny +3 more
doaj +1 more source