Results 51 to 60 of about 88,400 (300)

Macrolide Resistance in Mycoplasma pneumoniae, Israel, 2010

, 2011
Macrolide resistance in Mycoplasma pneumoniae is often found in Asia but is rare elsewhere. We report the emergence of macrolide-resistant M. pneumoniae in Israel and the in vivo evolution of such resistance during the treatment of a 6-year-old boy with ...
Dan Engelhard, Allon E. Moses, Ran Nir-Paz, Diana Averbuch, Carlos Hidalgo-Grass   +4 more
core   +1 more source

Role of ethambutol and rifampicin in the treatment of Mycobacterium avium complex pulmonary disease

BMC Pulmonary Medicine, 2019
Background A three-drug regimen (macrolide, ethambutol, and rifampicin) is recommended for the treatment of Mycobacterium avium complex pulmonary disease (MAC-PD).
Hyung-Jun Kim, Jong Sik Lee, Nakwon Kwak, Jaeyoung Cho, Chang-Hoon Lee, Sung Koo Han, Jae-Joon Yim   +6 more
doaj   +1 more source

Bacteriological and Molecular Identification of some Campylobacter Species in Broilers and their Macrolide Resistance Profile [PDF]

Benha Veterinary Medical Journal, 2018
Genus campylobacter including several species is of great importance that is considered among the major causative agents of acute diarrheal diseases in humans worldwide.
Ahmed Hefny, Heba Ahmed, Ahmed Ammar, Ashraf Abd El Tawab   +3 more
doaj   +1 more source

Detection of macrolide and fluoroquinolone resistance-associated 23S rRNA and parC mutations in Mycoplasma genitalium by nested real-time PCR

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundTraditional drug susceptibility testing cannot be performed in clinical laboratories due to the slow-growing characteristics of Mycoplasma genitalium when cultured in vitro. Sanger sequencing is the standard method for detecting drug resistance-
Wenyin He, Ying Yuan, Junyu Liang, Xuejiao Fan, Lei Li, Xingfei Pan   +5 more
doaj   +1 more source

Aberrant spliceosome activity via elevated intron retention and upregulation and phosphorylation of SF3B1 in chronic lymphocytic leukemia

Molecular Therapy: Nucleic Acids
Splicing factor 3b subunit 1 (SF3B1) is the largest subunit and core component of the spliceosome. Inhibition of SF3B1 was associated with an increase in broad intron retention (IR) on most transcripts, suggesting that IR can be used as a marker of ...
Manoj Kumar Kashyap, Hiren Karathia, Deepak Kumar, Roberto Vera Alvarez, Jose Vicente Forero-Forero, Eider Moreno, Juliana Velez Lujan, Carlos Ivan Amaya-Chanaga, Newton Medeiros Vidal, Zhe Yu, Emanuela M. Ghia, Paula A. Lengerke-Diaz, Daniel Achinko, Michael Y. Choi, Laura Z. Rassenti, Leonardo Mariño-Ramírez, Stephen M. Mount, Sridhar Hannenhalli, Thomas J. Kipps, Januario E. Castro   +19 more
doaj   +1 more source

Macrolides: The Plug Is Out [PDF]

Cell, 2012
Macrolide antibiotics are thought to clog up the ribosomal tunnel and thereby block general protein synthesis. By using a combination of elegant in vivo and in vitro approaches, Kannan et al. show that the inhibitory action of these drugs on bacterial protein synthesis is selective rather than global.
Gamerdinger, Martin, Deuerling, Elke
openaire   +3 more sources

Antimicrobial drug use and macrolide-resistant **Streptococcus pyogenes**, Belgium

, 2012
: In Belgium, decreasing macrolide, lincosamide, streptogramins B, and tetracycline use during 19972007 correlated significantly with decreasing macrolide-resistant Streptococcus pyogenes during 19992009.
Samuel Coenen, Surbhi Malhotra-Kumar, Hens, Niel, van Heirstraeten, Liesbet, Liesbet Van Heirstraeten, Christine Lammens, Herman Goossens, Malhotra-Kumar, Surbhi, Coenen, Samuel, Goossens, Herman, Lammens, Christine, Niel Hens   +11 more
core   +1 more source

Macrolide resistance determinants among isolates from carriers in Central Greece [PDF]

, 2012
Background: We sought to characterize the temporal trends in nasopharyngeal carriage of macrolide-resistant pneumococci during a period with increased heptavalent pneumococcal conjugate vaccine (PCV7) coverage in Central Greece.
Grivea, I. N., Tsantouli, A. G., Alexia Sourla, Denise C Chryssanthopoulou, Syrogiannopoulos, G. A., George A Syrogiannopoulos, Ntokou, E., Sourla, A., Eleni Ntokou, Alexandra G Tsantouli, Chryssanthopoulou, D. C., Ioanna N Grivea   +11 more
core   +2 more sources

Detection of pbp2b and ermB genes in clinical isolates of Streptococcus pneumoniae

Journal of Infection in Developing Countries, 2008
Background: Streptococcus pneumoniae is a major human pathogen. The emergence of penicillin resistant strains since the 1970s has been life threatening and the evolution of the bacteria have enabled itself to develop resistance to many other antibiotics ...
Navindra Kumari, Parasakthi Navaratnam, Shamala Devi Sekaran   +2 more
doaj   +1 more source

Imidazoquinolines with improved pharmacokinetic properties induce a high IFNα to TNFα ratio in vitro and in vivo

Frontiers in Immunology, 2023
TLR Agonists have promising activity in preclinical models of viral infection and cancer. However, clinical use is only in topical application. Systemic uses of TLR-ligands such as Resiquimod, have failed due to adverse effects that limited dose and thus,
Manuel Keppler, Simon Straß, Simon Straß, Sophia Geiger, Tina Fischer, Nadja Späth, Thilo Weinstein, Anna Schwamborn, Jamil Guezguez, Jan-Hinrich Guse, Stefan Laufer, Michael Burnet   +11 more
doaj   +1 more source