Results 101 to 110 of about 41,122 (231)

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, Volume 13, Issue 56, 9 October 2026.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3656-3665, October 2026.
Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson, Deeyen Karsanji, Bonifride Tuyishimire, Joanna Parkinson, Maria Heijer, Tadeusz Pawlik, Judith Hartleib‐Geschwindner, Maria Leonsson‐Zachrisson, Hans Ericsson   +8 more
wiley   +1 more source

Controlled release of Clarithromycin from PLGA microspheres enhances bone regeneration in rabbit calvaria defects [Elektronisk resurs]

, 2018
Purpose: To evaluate the controlled release effect of Clarithromycin loaded in PLGA microspheres in a rabbit calvaria defect model. Methods: Clarithromycin-loaded PLGA microspheres (MSPs) were formulated by modified O/W single emulsion/solvent ...
Prananingrum, Widyasri,, Ozeki, Tetsuya,, Tagami, Tatsuaki,, Terukina, Takayuki,, Alenezi, Ali,, Jimbo, Ryo,, Naito, Yoshihito,, Jinno, Yohei,, Galli, Silvia,   +8 more
core   +1 more source

Survival benefit associated with clarithromycin in severe community-acquired pneumonia: A matched comparator study

, 2020
Although analysis of retrospective studies has documented survival benefit from the addition of a macrolide to the treatment regimen for community-acquired pneumonia (CAP), no data are available to determine if there is differential efficacy between ...
Kyriakoudi, A., Kyriazopoulou E., Sinapidis D., Halvatzis S., Velissaris D., Alexiou N., Kosmas V., Adami M.-E., Kyprianou M., Kyprianou A., Stefos A., Lada M., Koutoukas P., Pavlaki M., Kyriakoudi A., Makina A., Gogos C., Niederman M.S., Giamarellos-Bourboulis E.J., Lada, M., Adami, M.-E., Giamarellos-Bourboulis, E.J., Pavlaki, M., Kyriazopoulou, E., Sinapidis, D., Stefos, A., Koutoukas, P., Gogos, C., Kosmas, V., Kyprianou, A., Alexiou, N., Niederman, M.S., Makina, A., Velissaris, D., Kyprianou, M., Halvatzis, S.   +18 more
core   +1 more source

Utility of Metagenomic Next‐Generation Sequencing in Identifying Anaerobic Pathogens in a Pediatric Brain Abscess Secondary to Sinusitis: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT In this pediatric brain abscess case, metagenomic next‐generation sequencing (mNGS) identified an anaerobic bacterium that remained undetected using conventional culture methods, thus providing clinically relevant information for antimicrobial management. This indicates that mNGS may be a useful adjunct for optimizing treatment strategies.
Risa Nagase, Kunihiro Oba, Mari Asakura, Masashi Ogasawara, Masahiro Noda, Yusuke Yamada, Asayo Furukawa, Naoki Kojima, Masanori Hashino, Kazuhiro Horiba   +9 more
wiley   +1 more source

Clinical Characterization of Enzyme and Transporter Precipitants to Evaluate Drug–Drug Interactions for Orforglipron, a Small Molecule Glucagon‐Like Peptide‐1 Receptor Agonist

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 979-990, October 2026.
Orforglipron is an orally administered, small‐molecule glucagon‐like peptide‐1 receptor agonist in clinical development for the treatment of type 2 diabetes and obesity. Orforglipron is a substrate of CYP3A4, organic anion transporting polypeptides (OATPs) 1B/1B3, and P‐glycoprotein (P‐gp); however, precipitants commonly used to define these mechanisms
Bridget L. Morse, David E. Coutant, Xiaosu Ma, Sohini Raha, Keerthan Aithal, Clare Nicoll, Luc R. A. Rougée, Shobha Bhattachar   +7 more
wiley   +1 more source

Clarithromycin adjunct treatment leads to substantial financial savings in community-acquired pneumonia: sub-analysis of the ACCESS trial

Journal of Global Antimicrobial Resistance
BACKGROUND: In the ACCESS randomized controlled trial addition of oral clarithromycin 500mg two times daily for seven days to standard-of-care (SoC) antibiotics provided substantial clinical benefit in adult patients hospitalized for community-acquired ...
Vasiliki Rapti, Elisavet Tasouli, Antigone Kotsaki, Georgios Niotis, Marios Chatzopoulos, Eirini Christaki, Evangelos J. Giamarellos Bourboulis, Garyphalia Poulakou   +7 more
doaj   +1 more source

Determining a Treatment Regimen With Optimal Pregnancy Outcomes in Patients With Chronic Endometritis: A Systematic Review and Network Meta‐Analysis

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims Chronic endometritis (CE) negatively impacts pregnancy outcomes. This study aimed to compare the efficacy of various treatment regimens on pregnancy outcomes in women with CE. Methods We performed a systematic review followed by an NMA in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses
Zheng Gong, Yun‐huan Qiu, Xiaoli Zhao, Oiyie Pang, Yingqin Cao, Jumei Shi, Mengran Lang, Tian Xia   +7 more
wiley   +1 more source

Assessment of Knowledge and Attitudes Toward Potential Drug–Drug and Drug–Food Interactions and Associated Factors Among Health Care Professionals at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims The increased likelihood of potential drug–drug interactions (PDDIs) and food–drug interactions (FDIs) is primarily attributed to the increasing use of multiple medications and the practice of taking medicines with food. Healthcare professionals' (HCPs') knowledge and attitudes toward PDDIs and FDIs play a critical role in ...
Melese Legesse Mitku, Yeniewa Kerie Anagaw, Abera Dessie Dagnaw, Derso Teju Geremew, Yeshiwas Ayale Ferede, Tewodros Denekew Haile, Minichil Chanie Worku, Liknaw Workie Limenh, Azmeraw Bekele, Wondim Ayenew   +9 more
wiley   +1 more source

Clarithromycin sustained-release tablet may be an improper therapy for the eradication of

Therapeutic Advances in Gastroenterology
Background: Clarithromycin plays an important role in eradicating Helicobacter pylori ( H. pylori ) through quadruple therapy. However, there is limited research on whether different forms of clarithromycin dosage have similar efficacies against H ...
Xingsheng Zuo, Qingli Shen, Jing Luo, Yaqin Wang, Chenglong Zhao   +4 more
doaj   +1 more source