Results 101 to 110 of about 40,048 (221)

Population Pharmacokinetic Analysis of Brensocatib in Adult and Adolescent Patients With Non‐Cystic Fibrosis Bronchiectasis

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Brensocatib, a competitive and reversible oral DPP1 inhibitor, at 10 and 25 mg significantly reduced pulmonary exacerbation burden, and 25 mg also reduced lung function decline vs. placebo in patients with non‐cystic fibrosis bronchiectasis, hereafter bronchiectasis, in ASPEN (NCT04594369).
Helen Usansky, Anthony Cammarata, ChongHua Li, Sam Au Yeung, Christopher M. Rubino, Lin Wang, Ariel Teper, Carlos Fernandez, Kevin Mange   +8 more
wiley   +1 more source

Clarithromycin attenuates cyclophosphamide-induced mucositis in mice

, 2000
No universally recognized agent is available for prophylaxis or therapy of mucositis induced by chemotherapy or chemo-radiotherapy. The effect of clarithromycin on the severity of mucositis induced by cyclophosphamide was investigated using a mouse model.
Woo, PCY, Ng, WF, Leung, HCH, Tsoi, HW, Yuen, KY   +4 more
core   +1 more source

Leveraging Healthy Volunteers for Anticancer Drug Clinical Pharmacology Studies: A Review Article Featuring Futibatinib as an Example

Clinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Early clinical development of anticancer drugs traditionally focused on exploring candidate treatments in patients. For instance, due to their cytotoxic action, administration of chemotherapies to healthy volunteers (HVs) for evaluation of their pharmacokinetic profiles was not considered feasible nor ethical from a safety and tolerability ...
Aernout D. van Haarst, Sabina Paglialunga, Ziv Machnes, Ikuo Yamamiya, Nanae Hangai, Aram Oganesian   +5 more
wiley   +1 more source

Fulminant liver failure associated with clarithromycin.

, 2003
OBJECTIVE To report a patient developing fulminant liver failure while being treated with clarithromycin for pneumonia. CASE SUMMARY A 58-year-old white woman developed fulminant liver failure while being treated with the macrolide antibiotic ...
Eriksson U, Krähenbühl S, Terracciano L, Tietz A, Heim MH, Marsch S   +5 more
core   +1 more source

Clarithromycin adjunct treatment leads to substantial financial savings in community-acquired pneumonia: sub-analysis of the ACCESS trial

Journal of Global Antimicrobial Resistance
BACKGROUND: In the ACCESS randomized controlled trial addition of oral clarithromycin 500mg two times daily for seven days to standard-of-care (SoC) antibiotics provided substantial clinical benefit in adult patients hospitalized for community-acquired ...
Vasiliki Rapti, Elisavet Tasouli, Antigone Kotsaki, Georgios Niotis, Marios Chatzopoulos, Eirini Christaki, Evangelos J. Giamarellos Bourboulis, Garyphalia Poulakou   +7 more
doaj   +1 more source

Population‐Level Trends in Gastric Cancer Mortality and Incidence After Expansion of Japanese National Health Insurance Coverage for Helicobacter pylori Eradication: A Descriptive Time‐Trend Study

Helicobacter, Volume 31, Issue 5, September/October 2026.
ABSTRACT Background In February 2013, Japanese national health insurance coverage for Helicobacter pylori eradication was expanded to patients with H. pylori‐positive, endoscopically diagnosed chronic gastritis. This policy broadened access to eradication treatment, but its relationship with subsequent population‐level gastric cancer trends requires ...
Masahiro Asaka, Tokuma Tanuma, Akiko Kowada, Shouji Matsushima, Kozo Akino   +4 more
wiley   +1 more source

Clarithromycin sustained-release tablet may be an improper therapy for the eradication of

Therapeutic Advances in Gastroenterology
Background: Clarithromycin plays an important role in eradicating Helicobacter pylori ( H. pylori ) through quadruple therapy. However, there is limited research on whether different forms of clarithromycin dosage have similar efficacies against H ...
Xingsheng Zuo, Qingli Shen, Jing Luo, Yaqin Wang, Chenglong Zhao   +4 more
doaj   +1 more source

Pharmacokinetics of clarithromycin in the prostate tissue

, 2003
Purpose: We studied the pharmacokinetics of orally administrated clarithromycin in prostatic tissue to define its role in the treatment of chronic abacterial prostatitis caused by intracellular pathogens.
Panou, Charalampos, Πάνου, Χαράλαμπος   +1 more
core   +1 more source

Clarithromycin-induced mania in a child

, 2009
Clarithromycin is a macrolide antibiotic widely used in children with respiratory infections. Mania is an extremely rare psychiatric side effect. A pediatric case of typical manic symptoms associated with clarithromycin-use and resembling those in adults
T. Fidan, Fidan, V., Fidan, T., V. Fidan
core   +1 more source

Acute delirium, probably precipitated by clarithromycin

, 2001
Clarithromycin is a relatively new antibiotic with many applications. Its frequent use explains why side-effects previously reported seldom now become clear.
Pijlman, A H, Hoekstra, Joost B.L., van Puijenbroek, E P, Kuck, E M   +3 more
core