Results 71 to 80 of about 57,560 (274)

Pathophysiology of Antibiotic Resistance: Clarithromycin [PDF]

, 2000
Resistance of Helicobacter pylori to antibiotics ranges from 3% to 10% and may exceed these levels in some countries. The pathophysiology of clarithromycin resistance is reviewed, including the mode of action by which the antibiotic inhibits protein ...
Diane E Taylor
core   +1 more source

Therapeutic efficacy of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant and macrolide-sensitive Mycoplasma pneumoniae pneumonia in pediatric patients

PLoS ONE, 2017
Objective To clarify therapeutic effects of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant Mycoplasma pneumoniae (MRMP) pneumonia and against macrolide-sensitive Mycoplasma pneumoniae (MSMP) pneumonia in pediatric ...
N. Ishiguro, Naoko Koseki, Miki Kaiho, T. Ariga, H. Kikuta, T. Togashi, Koji Oba, Keisuke Morita, N. Nagano, M. Nakanishi, K. Hara, Kyosuke Hazama, Toru Watanabe, T. Yamanaka, S. Sasaki, H. Furuyama, M. Shibata, S. Shida, A. Ishizaka, Y. Tabata, Hayato Aoyagi, Hiroyuki Naitō, M. Yoshioka, A. Horino, T. Kenri   +24 more
semanticscholar   +1 more source

Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population‐Based Study

Clinical Pharmacology &Therapeutics, EarlyView.
Fentanyl, hydromorphone, and oxycodone are metabolized by cytochrome P450 3A4 (CYP3A4). Co‐administration with CYP3A4‐inhibiting macrolides (clarithromycin or erythromycin) may increase opioid concentrations and overdose risk, but the clinical impact of these interactions is unknown.
Tony Antoniou, Joanna Yang, David N. Juurlink, Joanne M.‐W. Ho, Muhammad Mamdani, Fangyun Wu, Mina Tadrous, Tara Gomes   +7 more
wiley   +1 more source

The Effect of Cytochrome P450 and Organic Anion Transporter Polypeptide on Macrolides–Atorvastatin Drug Interaction

Iraqi Journal of Industrial Research
Cytochrome P450 (CYP3A4) enzymes and organic anion-transporting polypeptides (OATPs) are critical in drug pharmacokinetics. Fifteen rabbits were divided into three groups: the atorvastatin group received a single oral dose of atorvastatin (0.86 mg/kg B ...
Zainab Farooq Abdalhameed, Orooba Mohammed Saeed Ibrahim   +1 more
doaj   +1 more source

Population Pharmacokinetics of Ticagrelor during Veno‐Arterial ECMO in Acute Coronary Syndrome: Model‐Informed Dosing Simulations

Clinical Pharmacology &Therapeutics, EarlyView.
Although patients with acute coronary syndrome supported by veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) have a high risk of thrombosis and bleeding, antiplatelet pharmacology in this setting is not well defined. This prospective observational study investigated the population pharmacokinetics of ticagrelor and its active metabolite AR ...
Soyoung Kang, Kyoung Lok Min, Seungwon Yang, Jongsung Hahn, Dasohm Kim, Byung Hak Jin, Soon Uk Chae, Soo Kyung Bae, Jin Wi, Min Jung Chang   +9 more
wiley   +1 more source

Role of MIC levels and 23S rRNA mutation sites to clarithromycin in 14-day clarithromycin bismuth quadruple therapy for Helicobacter pylori eradication: A prospective trial in Beijing

Heliyon
Background: Rising clarithromycin resistance undermines Helicobacter pylori (H. pylori) treatment efficacy. We aimed to determine clarithromycin's minimum inhibitory concentration (MIC) levels and identify specific mutation sites in the 23S ribosomal ...
Ying Chen, Siyu Li, Wenbin Li, Yiran Wang, Jihua Shi, Xue Xu, Pan Zhang, Dan Chen, Rui Gang, Qingfeng Luo   +9 more
doaj   +1 more source

Comparative efficacy of azithromycin versus clarithromycin in combination with beta-lactams to treat community-acquired pneumonia in hospitalized patients: a systematic review

Journal of International Medical Research, 2021
Objective The objective was to compare the efficacy of azithromycin and clarithromycin in combination with beta-lactams to treat community-acquired pneumonia among hospitalized adults.
Jumana Al-Salloum, Syed Wasif Gillani, Rana Kamran Mahmood, Shabaz Mohiuddin Gulam   +3 more
doaj   +1 more source

Identification of Erythromycin and Clarithromycin Metabolites Formed in Chicken Liver Microsomes Using Liquid Chromatography–High-Resolution Mass Spectrometry

Foods, 2021
Nontargeted analysis can be used for the rapid screening and confirmatory analysis of veterinary drugs and their metabolites, which are important for the comprehensive safety evaluation of animal-derived foods.
Bo Wang, Soyeon Nam, Eunyeong Kim, Hayoung Jeon, Kiho Lee, Kaizhou Xie   +5 more
doaj   +1 more source

Update on clarithromycin resistance in Helicobacterpylori in Hong Kong and its effect on clarithromycin-based triple therapy

, 2005
Aim To update the antibiotic susceptibility of Helicobacter pylori andevaluate the efficacy of a clarithromycin-based triple therapy in rela-tion to metronidazole and/or clarithromycin resistance in Hong Kong.
Gu, Q, Chan, CK, Wang, J, Xia, HHX, Wong, BCY, Kung, H, Chan, OO, Cheung, KL, Fung, FMY, Lai, KC, Yuen, MF, Wong, KW   +11 more
core   +1 more source

Antagonism between Front-Line Antibiotics Clarithromycin and Amikacin in the Treatment of Mycobacterium abscessus Infections Is Mediated by the whiB7 Gene

Antimicrobial Agents and Chemotherapy, 2017
Combinations of antibiotics, each individually effective against Mycobacterium abscessus, are routinely coadministered based on the concept that this minimizes the spread of antibiotic resistance. However, our in vitro data contradict this assumption and
Mark Pryjma, J. Burian, Kevin S. Kuchinski, C. Thompson   +3 more
semanticscholar   +1 more source