Results 51 to 60 of about 57,560 (274)

Helicobacter pylori Eradication According to Sequencing-Based 23S Ribosomal RNA Point Mutation Associated with Clarithromycin Resistance

Journal of Clinical Medicine, 2019
Background/Aims: Clarithromycin resistance in Helicobacter pylori is associated with point mutations in the 23S ribosomal RNA (rRNA) gene. We investigated the point mutations in the 23S rRNA genes of patients with clarithromycin-resistant H.
S. Seo, B. Do, Jin Gu Kang, H. Kim, M. Jang, Hak-Yang Kim, W. Shin   +6 more
semanticscholar   +1 more source

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

British Journal of Clinical Pharmacology, EarlyView.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp, Martijn L. Manson, Henk‐Jan Guchelaar, Stefan Böhringer, Esther H. M. van Egmond, Peter A. von dem Borne, Jesse J. Swen   +6 more
wiley   +1 more source

Clarithromycin-resistant Helicobacter pylori in Recife, Brazil, directly identified from gastric biopsies by polymerase chain reaction

Arquivos de Gastroenterologia, 2010
CONTEXT: Clarithromycin is the most effective drug used in the eradication of infection by Helicobacter pylori. Due to worldwide increase in resistance, pre-treatment susceptibility testing for clarithromycin is recommended.
Ana Kelly Lins, Roberto A Lima, Marcelo Magalhães   +2 more
doaj   +1 more source

Clarithromycin-Induced Digoxin Intoxication

, 1997
Objective To report a case of clarithromycin-induced digoxin intoxication. Case Summary A 78-year-old white man with ischemic cardiomyopathy and chronic renal insufficiency was admitted 4 days after being prescribed clarithromycin for a suspected episode
Patrice Laberge, Pierre Martineau
core   +1 more source

Cardiovascular outcomes associated with use of clarithromycin: population based study

British medical journal, 2016
Study question What is the association between clarithromycin use and cardiovascular outcomes? Methods In this population based study the authors compared cardiovascular outcomes in adults aged 18 or more receiving oral clarithromycin or amoxicillin ...
A. Wong, A. Root, I. Douglas, C. Chui, E. Chan, Yonas Ghebremichael-Weldeselassie, C. Siu, L. Smeeth, I. Wong   +8 more
semanticscholar   +1 more source

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

Short Course Monotherapy with Clarithromycin for Localized Mycobacterium Marinum Skin Infection

Canadian Journal of Infectious Diseases, 1997
In vitro studies have shown that Mycobacterium marinum is usually susceptible to clarithromycin. However, there are limited published data on the clinical use of clarithromycin for the treatment of M marinum infections. This report describes a previously
Mitchell R Weinstein, Donald E Low, Tony Mazzulli   +2 more
doaj   +1 more source

A study of the electrochemical activity of some macrolide antibiotics on a gold electrode in a neutral electrolyte [PDF]

Journal of the Serbian Chemical Society, 2007
The aim of the present study is to present the different reactivity of azithromycin and clarithromycin (pure and commercial) at a gold electrode in neutral electrolyte using cyclic linear sweep voltammetry under the same experimental conditions.
Avramov-Ivić Milka L., Petrović Slobodan D., Mijin D.Ž.   +2 more
doaj   +1 more source

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source

Rifabutin Acts in Synergy and Is Bactericidal with Frontline Mycobacterium abscessus Antibiotics Clarithromycin and Tigecycline, Suggesting a Potent Treatment Combination

Antimicrobial Agents and Chemotherapy, 2018
Mycobacterium abscessus is a rapidly emerging mycobacterial pathogen causing dangerous pulmonary infections. Because these bacteria are intrinsically multidrug resistant, treatment options are limited and have questionable efficacy. The current treatment
Mark Pryjma, J. Burian, C. Thompson
semanticscholar   +1 more source