Results 31 to 40 of about 30,368 (178)

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson, Deeyen Karsanji, Bonifride Tuyishimire, Joanna Parkinson, Maria Heijer, Tadeusz Pawlik, Judith Hartleib‐Geschwindner, Maria Leonsson‐Zachrisson, Hans Ericsson   +8 more
wiley   +1 more source

Clarithromycin induced reversible sensorineural hearing loss

B-ENT, 2011
Clarithromycin induced reversible sensorineural hearing loss. Objective: We present a rare case of reversible sensorineural hearing loss caused by clarithromycin.
J. K. Hajiioannou, V. Florou, P. Kousoulis, M. Fragkos, E. Moshovakis   +4 more
doaj   +2 more sources

Short Course Monotherapy with Clarithromycin for Localized Mycobacterium Marinum Skin Infection

Canadian Journal of Infectious Diseases, 1997
In vitro studies have shown that Mycobacterium marinum is usually susceptible to clarithromycin. However, there are limited published data on the clinical use of clarithromycin for the treatment of M marinum infections. This report describes a previously
Mitchell R Weinstein, Donald E Low, Tony Mazzulli   +2 more
doaj   +1 more source

A study of the electrochemical activity of some macrolide antibiotics on a gold electrode in a neutral electrolyte [PDF]

Journal of the Serbian Chemical Society, 2007
The aim of the present study is to present the different reactivity of azithromycin and clarithromycin (pure and commercial) at a gold electrode in neutral electrolyte using cyclic linear sweep voltammetry under the same experimental conditions.
Avramov-Ivić Milka L., Petrović Slobodan D., Mijin D.Ž.   +2 more
doaj   +1 more source

Bismuth-Based Quadruple Therapy versus Metronidazole-Intensified Triple Therapy as a First-Line Treatment for Clarithromycin-Resistant Helicobacter pylori Infection: A Multicenter Randomized Controlled Trial

Gut and Liver, 2022
Background/Aims: Clarithromycin resistance is a main factor for treatment failure in the context of Helicobacter pylori infection. However, the treatment regimen for clarithromycin-resistant H. pylori infection has not yet been determined.
Seung In Seo, Hyun Lim, Chang Seok Bang, Young Joo Yang, Gwang Ho Baik, Sang Pyo Lee, Hyun Joo Jang, Sea Hyub Kae, Jinseob Kim, Hak Yang Kim, Woon Geon Shin   +10 more
doaj   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Advanced nanotherapeutics for combating ocular infections: Rational design, antimicrobial mechanisms, and therapeutic breakthroughs

BMEMat, EarlyView.
Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu, Xuetian Wen, Yue Tan, Rui Zeng, Yijuan Zhang, Tong Lin, Lan Gong, Zichao Luo   +7 more
wiley   +1 more source

Identification of Erythromycin and Clarithromycin Metabolites Formed in Chicken Liver Microsomes Using Liquid Chromatography–High-Resolution Mass Spectrometry

Foods, 2021
Nontargeted analysis can be used for the rapid screening and confirmatory analysis of veterinary drugs and their metabolites, which are important for the comprehensive safety evaluation of animal-derived foods.
Bo Wang, Soyeon Nam, Eunyeong Kim, Hayoung Jeon, Kiho Lee, Kaizhou Xie   +5 more
doaj   +1 more source

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics

Chemistry – A European Journal, EarlyView.
A series of structurally diverse exoglycals was synthesized using a modified Julia‐olefination approach from sugar‐derived precursors. These glycosidase transition‐state mimics were further diversified via CuAAC chemistry to yield triazole‐conjugated analogues.
Elisa Ospanow, Oscar L. Alferez, David L. Jakeman   +2 more
wiley   +1 more source

Primary resistance to clarithromycin, metronidazole and amoxicillin of Helicobacter pylori isolated from Tunisian patients with peptic ulcers and gastritis: a prospective multicentre study

Annals of Clinical Microbiology and Antimicrobials, 2010
Background The frequency of primary resistance to antibiotics in H. pylori isolates is increasing worldwide. In Tunisia, there are limited data regarding the pattern of H. pylori antibiotic primary resistance. Aim To evaluate the primary resistance of H.
Ben Mansour Khansa, Burucoa Christophe, Zribi Meriem, Masmoudi Afef, Karoui Sami, Kallel Lamia, Chouaib Soufiène, Matri Samira, Fekih Monia, Zarrouk Sonia, Labbene Mounir, Boubaker Jalel, Cheikh Imed, Hriz Mongi, Siala Nadia, Ayadi Abdelkarim, Filali Azza, Mami Nabil, Najjar Taoufik, Maherzi Ahmed, Sfar Mohamed, Fendri Chedlia   +21 more
doaj   +1 more source