Results 91 to 100 of about 2,368,811 (205)

Neutrophils: Heterogeneity, Biology, Diseases, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neutrophils exhibit remarkable functional plasticity and play dual roles in tissue protection and disease progression. This review summarizes their key biological functions and highlights the shift from conventional broad‐spectrum interventions to neutrophil‐based drug delivery systems.
Yibing Zhang, Siwen Wu, Yusi Wang, Die Hu, Li Yang   +4 more
wiley   +1 more source

Primary Ciliary Dyskinesia that Responded to Long-Term, Low-Dose Clarithromycin [PDF]

, 2010
A 46-year-old man was referred to our hospital with hemoptysis. He had been diagnosed with chronic sinusitis since childhood, but had received no treatment. Chest CT showed a diffuse centrilobular granular shadow and thickened bronchial walls.
Kakugawa, Tomoyuki, Ishimatsu, Yuji, Noriho Sakamoto, Yuji Ishimatsu, Hiroshi Mukae, Ishii, Hiroshi, Tomoyuki Kakugawa, Kadota, Jun-ichi, Mukae, Hiroshi, Kohno, Shigeru, Shigeru Kohno, Yoshioka, Daisuke, Daisuke Yoshioka, Hiroshi Ishii, Sakamoto, Noriho, Jun-ichi Kadota   +15 more
core   +1 more source

Comparison of FISH, RFLP and agar dilution methods for testing clarithromycin resistance of Helicobacter pylori

The Turkish Journal of Gastroenterology, 2014
Background/Aims: Clarithromycin resistance is an important factor of Helicobacter pylori (H. pylori) eradication failure in adults and children.
İhsan Hakkı Çiftci, Meltem Uğraş, Gürsel Acartürk, Gülşah Aşık, Birol Şafak, Fatma Hüsniye Dilek   +5 more
doaj   +1 more source

Asthma: From Phenotypes to Endotypes—Beyond Type 2 Inflammation

Respirology, Volume 31, Issue 11, Page 1077-1090, November 2026.
ABSTRACT Asthma is a heterogeneous syndrome featuring variable pathophysiology, clinical presentation and treatment response. This review examines a comprehensive endotype‐phenotype framework for asthma assessment with an emphasis on characteristics beyond T2 inflammatory status alone.
Mario Fernando, Gregory G. King
wiley   +1 more source

Susceptibility‐Guided Versus Empirical Therapy for Helicobacter pylori Infection in a High Resistance Setting: A Randomised Controlled Trial

MicrobiologyOpen
Clarithromycin resistance is a major determinant of treatment failure, and the benefits of susceptibility‐guided therapy in high‐resistance settings remains incompletely understood.
Kemei Lu, Xuefei Zou, Cuicui Lang, Lina Zang, Xuechao Yang, Weiwei Sang, Jinyan Wang, Qian Feng, Ying Mu, Lifeng Liu, Chunhong Xu, Jingrun Zhao   +11 more
doaj   +1 more source

Clarithromycin Resistance Rates of Helicobacter pylori Infected Gastric Biopsies in Korea

Korean Journal of Clinical Laboratory Science
Gastric biopsies or tissue samples (4,698 samples) were collected from 50 local clinics or hospitals between January 2022 and December 2024 for the molecular detection of Helicobacter pylori and clarithromycin resistance using 23S ribosomal RNA genes ...
Moo-Sang CHONG, Kyutaeg LEE
doaj   +1 more source

Crystal structure of tyrosine‐tRNA synthetase from Helicobacter pylori G27

Acta Crystallographica Section F, Volume 82, Issue 11, Page 369-375, November 2026.
The production, crystallization and 2.2 Å resolution structure of H. pylori tyrosine‐tRNA synthetase are reported.Helicobacter pylori, a major cause of gastric ulcers and cancers, infects nearly half of the world's population. The crystal structure of a potential H.
David Igbalajobi, Jason E. Taylor, Raymond Gao, Jesuferanmi Ayanlade, Rachael Zigweid, Sandhya Subramanian, Hannah Udell, Thomas E. Edwards, Jan Abendroth, Donald Lorimer, Peter J. Myler, Bart Staker, Edmund Moses Ndip, Oluwatoyin A. Asojo   +13 more
wiley   +1 more source

Role of MIC levels and 23S rRNA mutation sites to clarithromycin in 14-day clarithromycin bismuth quadruple therapy for Helicobacter pylori eradication: A prospective trial in Beijing

Heliyon
Background: Rising clarithromycin resistance undermines Helicobacter pylori (H. pylori) treatment efficacy. We aimed to determine clarithromycin's minimum inhibitory concentration (MIC) levels and identify specific mutation sites in the 23S ribosomal ...
Ying Chen, Siyu Li, Wenbin Li, Yiran Wang, Jihua Shi, Xue Xu, Pan Zhang, Dan Chen, Rui Gang, Qingfeng Luo   +9 more
doaj   +1 more source

Lack of Usefulness of Literature‐Based Helicobacter pylori Resistance Data for Predicting First‐Line Empirical Treatment Effectiveness in the European Registry on H. pylori Management (Hp‐EuReg)

Helicobacter, Volume 31, Issue 6, November/December 2026.
ABSTRACT Background Helicobacter pylori (H. pylori) infection causes gastritis, peptic ulcer disease, and gastric cancer. Without an effective vaccine, eradication therapy remains crucial. However, increasing antibiotic resistance compromises treatment effectiveness.
Ismail Kirrout, Olga P. Nyssen, Ángeles Pérez‐Aísa, Bojan Tepes, Irina N. Voynovan, Samuel J. Martínez‐Domínguez, Alfredo J. Lucendo, Ludmila G. Vologzanina, Matteo Pavoni, Sayar R. Abdulkhakov, Maja Denkovski, Javier Tejedor‐Tejada, Tatiana Ilchishina, Luis Bujanda, Aiman S. Sarsenbaeva, Jose M. Huguet, Oleg Zaytsev, Boris D. Starostin, Monica Perona, Antonietta G. Gravina, Manuel Pabón‐Carrasco, Sergey A. Alekseenko, Óscar Núñez, Miguel Areia, Jesús Barrio, Antonio Moreno Loro, Dmitry N. Andreev, Blas José Gómez Rodríguez, María Soledad Marcos, Inmaculada Ortiz‐Polo, Galina N. Tarasova, Igor Bakulin, Mónica Sánchez Alonso, Irene Arteagoitia, Virginia Flores, Manuel Jiménez‐Moreno, Dmitry S. Bordin, Antonio Gasbarrini, Ricardo Marcos‐Pinto, Wojciech Marlicz, Perminder S. Phull, Marino Venerito, Doron Boltin, Lyudmila Boyanova, Pablo Parra, Leticia Moreira, Francis Mégraud, Colm O'Morain, Nuria Montes, Javier P. Gisbert, on behalf of the Hp‐EuReg investigators, Natalia N. Dekhnich, Pilar Mata‐Romero, Natalia Valerievna Bakulina, Alla G. Kononova, Giuseppe Losurdo, Judith Gomez‐Camarero, Alma Keco‐Huerga, Pablo M. Wolfe García, Jurij Bednarik, Eduardo Iyo, Antonia Perelló, Luis Fernández‐Salazar, Noelia Alcaide, Benito Velayos, Pedro Almela, Ramón Pajares Villarroya, Daniel Martin‐Holgado, Miguel Fernández‐Bermejo, Ian L. P. Beales, Alisan Kahraman, Ana Beatriz Pozo Blanco, Montserrat Planella, Mikel Ganuza, Victor A. Kamburov, Marina F. Osipenko, Debora Compare, Georges Kamtoh, Rosa Rosania, Eva Barreiro Alonso, Maria A. Livzan, Teresa Angueira, Consuelo Ramírez, Piotr Szredzki, Natalia Baryshnikova, Natalia Bakanova, Pedro Delgado Guillena, Sheyla Montori Pina, Eduardo Albéniz, Piotr Eder, Inna V. Savilova, Henrique Fernandes‐Mendes, Miguel Suárez Matías, María Badía Martínez, Liya Nikolaevna Belousova, Benito Hermida Pérez, Ana Garre, Natasa Brglez Jurecic, Olga Kolokolnikova, Paola Chaudarcas, Luis Hernández, Regina I. Khlynova, Antonio Cuadrado, Marta Pascual‐Mato, Ekaterina Y. Plotnikova, Mila Kovacheva‐Slavova, Ramiro Carreño Macián, Manon C. W. Spaander, Guillem Soy, Pilar Pazo Mejide, Sergio Gil Rojas, Carlos Maroto‐Martín, Francisco J. Rancel‐Medina, Diego Burgos‐Santamaría, Isabel Pérez‐Martínez, Giulia Fiorini, Teresa Valdés‐Lacasa, Riccardo Vasapolli, Rosa M. Sáiz‐Chumillas, Tamara Matysiak‐Budnik, Anna L. Pakhomova, Jorge Yebra Carmona, Diego Ledro Cano, Senador Moran Sanchez, Jan Bornschein, Pilar Bernal Checa, Antonio M. Caballero‐Mateos, Leticia Gimeno Pitarch, Ángela Martínez Herreros, Nerea Alonso‐Bilbao, Patricia Sanz‐Segura, Jose Xavier Segarra Ortega, Raquel García‐Sánchez, Alexander Link, Jesus M. Gonzalez‐Santiago, Laura Larrey Ruiz, Rodrigo Garcés‐Durán   +136 more
wiley   +1 more source

Antimicrobial Resistance in Periodontal Disease: Rethinking Adjunctive Therapy in the Metagenomics Era, the Pressing Need for Precision Treatment and Periodontal Resistome Mapping

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Systemic antibiotics are effective when used as adjunctive therapy in the treatment of periodontitis; however, their use must be balanced against antimicrobial resistance, which is a major threat to global public health. This review provides an expert synthesis of the literature and a field‐level overview of antimicrobial resistance in ...
Meera Alghafri, Lindsey Edwards, David Moyes, Luigi Nibali   +3 more
wiley   +1 more source