Results 121 to 130 of about 5,729,237 (367)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Effects of Class Orientation on Sense of Fulfillment and Self-Growth at the University Level: Mediated by Academic Engagement

, 2023
Rumi Matsushima, Hitomi Ozaki
openalex   +2 more sources

Digital Backchannel: Promoting Students' Engagement in EFL Large Class

International Journal of Emerging Technologies in Learning (iJET), 2019
Students’ engagement is widely believed to be the single most significant predictor of persistence in learning process. It is generally reflected in active participation such as listening to presentation, expressing opinions, asking questions, and ...
Siti Yulidhar Harunasari, Nurhasanah Halim   +1 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Evaluating the Role of Professional Identity and Future Orientation in Enhancing Learning Engagement Among Special Education Majored Students: A Moderated Mediation Effect

SAGE Open
This research delves into the intricate relationship between special education majored students’ perceptions of classroom atmosphere and their learning engagement, while also investigating the mediating influence of professional identity and the ...
Tan Shaojie
doaj   +1 more source

Implementing Flipped Classroom to Enhance Student Engagement: An Action Research [PDF]

E-Journal of Humanities, Arts and Social Sciences
The flipped classroom, also known as inverted instruction, has gained significant attention recently. This teaching method involves students engaging with resources and activities, such as watching videos before class.
Nana Yaw Brenya Agyeman, Venessa Aphane
doaj   +1 more source

Interactions between teaching assistants and students boost engagement in physics labs

, 2014
Through in-class observations of teaching assistants (TAs) and students in the lab sections of a large introductory physics course, we study which TA behaviors can be used to predict student engagement and, in turn, how this engagement relates to ...
Roll, Ido, Stang, Jared B.
core   +2 more sources

Using learning analytics with temporal modeling to uncover the interplay of before-class video viewing engagement, motivation, and performance in an active learning context

, 2023
Jiun‐Yu Wu, Chen‐Hsuan Liao, Chin‐Chung Tsai, Oi‐Man Kwok   +3 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source