Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Teaching and engaging students in large classes
Mental Health Clinician, 2013 Teaching large classes can be a challenge, especially if you are doing this for the first time. This article addresses how to approach teaching large classes and provides some strategies for promoting student engagement to facilitate learning.
openaire +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
PLoS ONEStudent engagement assessment in online learning faces critical limitations: traditional methods fail to capture engagement's dynamic, multidimensional nature, particularly in second language (L2) contexts where emotional factors are paramount.
Xuhui Hu, Jian Gao
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Classe laborieuse, orientations politiques et engagements militants
Lectures, 2009 Parler de classe laborieuse, comme le fait l'intitule de ce dossier des Mondes du travail n'est pas anodin. Les auteurs se sont ainsi demarques du qualificatif plus courant de « populaire », comme pour insister sur leur place determinante dans les rapports de production. Mais c'est surtout le singulier de l'expression qui peut intriguer.
openaire +3 more sources
Preparing adolescents attending progressive and no-excuses urban charter schools to analyze, navigate, and challenge race and class inequality [PDF]
, 2016 Background/Context: Sociopolitical development (SPD) refers to the processes by which an individual acquires the knowledge, skills, emotional faculties, and commitment to recognize and resist oppressive social forces.
Clark, Shelby +10 more
core
“The Internet Is Keeping Me from Dying from Boredom”: Understanding the Management and Social Construction of the Self Through Middle-Class Indian Children’s Engagement with Digital Technologies During the COVID-19 Lockdown [PDF]
, 2022 Damanjit Sandhu, Ravinder Barn
openalex +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source