Results 151 to 160 of about 1,288,265 (300)

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

The relationship between perceived teacher support and learning engagement of Chinese adolescents: a moderated chain mediation model

BMC Psychology
Learning engagement affects academic performance, making junior high school students’ engagement a key educational concern. The present study examined the relationship between perceived teacher support and learning engagement, investigating the chain ...
Zihan Liu, Wenguang Tang, Liping Tang, Yankun Ma   +3 more
doaj   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

THE INFLUENCE OF TRANSFORMATIONAL LEADERSHIP ON EMPLOYEE WORK ENGAGEMENT IN CLASS IIA COMMUNITY INSTITUTIONS PURWOKERTO

Journal of Management Small and Medium Enterprises (SME's)
This research aims to see the influence of transformational leadership on employee work engagement at the Class IIA Purwokerto Penitentiary. This research method uses quantitative methods with primary data obtained from 88 employees of the Purwokerto ...
Fatkhul Hafidh, Rachmayanthy Rachmayanthy   +1 more
doaj  

Effects of intra-class peer mentorship intervention programme on the academic performances of academically underperforming medical students in Nigeria

BMC Medical Education
Background A significant gap exists in understanding the effectiveness of intra-class (same-class) level peer mentorship programmes designed to enhance academic performance, well-being, and student involvement among underperforming medical students. This
George Uchenna Eleje, David Chibuike Ikwuka, Kingsley Chinaza Nwosu, Lydia Ijeoma Eleje, Obiageli Ifeoma Ikwuka, Nasiru Sani, Jean Paul Niyoyita, Kazeem Bidemi Okesina, Uchechukwu Dimkpa, Uchechukwu Kevin Nwanna, Victor Bassey Archibong, Eric Twizeyimana, Niranjan Shridhar Divekar, Samuel Ifedioranma Ogenyi, Okwute Michael Ochayi, Marcus Bushaku, Elemi John Ani, Kingsley Chidiebere Nwaogu, Olufunke Onaadepo, Ibrahim Mohammed Sule, Emmanuel Chukwunweike Nwangwu, Chisom Adaobi Nri-Ezedi, Chinyere Ukamaka Onubogu, Arinze Anthony Onwuegbuna, Theophilus Osaje Okonoboh, Onyecherelam Monday Ogelle, Ezinne Ifeyinwa Nwaneli, Joseph Ifeanyichukwu Ikechebelu, Diresibachew Haile Wondimu, Edwin Okechukwu Nwobodo   +29 more
doaj   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source